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1,036 results for “Cell mechanics”
Supporting Data for "Why Half‐Cell Samples Provide Limited Insight Into the Aging Mechanisms of Potassium Batteries"
<p>This dataset provides the raw data to the manuscript</p> <p><strong>"Why Half‐Cell Samples Provide Limited Insight Into the Aging Mechanisms of Potassium Batteries"</strong></p> <p>published in Advanced Energy Materials, <strong>2024</strong>, DOI 10.1002/aenm.202403811</p> <p><a href="https://doi.org/10.1002/aenm.202403811">Link to Publisher</a></p> <p> </p> <p>Comments:</p> <ul> <li>HAXPES synchrotron data is provided as IGOR file (IGOR Pro (v6.37, WaveMaterics Inc.). The file contains the original 2D data and the converted 1D datasets used for analysis</li> <li>In-House XPS data is provided with corresponding peak fits as excel spreadsheet</li> <li>peak data (binding energy (after referencing), intensity, area, FWHM and at.%) is provided in separate excel spreadsheet.</li> </ul> <p> </p>
Studying gastrulation by invagination: the bending of a cell sheet by mechanical cell properties using 3D deformable cell based simulations
<p>This dataset contains the scripts and end results of invagination simulation experiments.<br>The data are the results of a 3D cell based model that was used to investigate invagination: the bending of a cell sheet, and uses cell-cell adhesion, apical constriction, cell volume conservation, collision detection and handeling.</p>
Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia
<p>Ribosome dysfunction underlies the pathogenesis of many cancers and heritable ribosomopathies. Here we investigate how mutations in either ribosomal protein large (RPL) or ribosomal protein small (RPS) subunit genes selectively affect erythroid progenitor development and clinical phenotypes in Diamond-Blackfan anemia (DBA), a rare ribosomopathy with limited therapeutic options. Using single-cell assays of patient-derived bone marrow, we delineated two distinct cellular trajectories segregating with ribosomal protein genotypes: almost complete loss of erythroid specification were observed in <em>RPS</em>-DBA. In contrast, we observed relative preservation of qualitatively abnormal erythroid progenitors and precursors in <em>RPL</em>-DBA. Although both DBA genotypes exhibited a pro-inflammatory bone marrow milieu, <em>RPS</em>-DBA was characterized by erythroid differentiation arrest, whereas <em>RPL</em>-DBA was characterized by preserved GATA1 expression and activity. Compensatory stress erythropoiesis in <em>RPL</em>-DBA exhibited disordered differentiation underpinned by an altered glucocorticoid molecular signature, including reduced <em>ZFP36L2</em> expression<em>,</em> leading to milder anemia and improved corticosteroid response. This integrative analysis approach identified distinct pathways of erythroid failure and defined genotype-phenotype correlations in DBA. These findings may help facilitate therapeutic target discovery.</p> <p> </p>
Dataset - Fast mechanical and biochemical cell wall dynamics underlie plant nutation
<p>Dataset and codes (Python and Matlab) used to produce the figures in the article "Fast mechanical and biochemical cell wall dynamics underlie plant nutation".</p>
The weaken-fill-repair model for cell budding: Linking cell wall biosynthesis with mechanics
<p>The interplay between cellular mechanics and other biochemical processes leading to the cell cycle is poorly understood. Here, we propose a quantitative model of the mechanism of cell budding, particularly for Saccharomyces cerevisiae, as a ''weaken-fill-repair'' process. This model links Newtonian mechanics over the cell wall with biochemical processes that change the mechanical properties of the wall. Our model shows that: (1) The oscillatory behavior in the size of the mother compartment during cell division, as observed experimentally, is an inevitable consequence of the budding mechanism; (2) The asymmetry of cell division is necessary for the daughter cell to maintain mechanical stiffness; (3) Although different aspects of a cell are strictly constrained and intricately interconnected, the budding process is governed by a single reduced parameter that, when at an appropriate value, can automatically achieve homeostasis. Our quantitative model of the evolution of cell walls and their impact on cell division could provide valuable insights into cell morphology from a system perspective. This knowledge could be instrumental in developing effective antimicrobial treatments against microorganisms with cell walls and even in building synthetic cells.</p>
Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea
ClinicalTrials.gov study NCT00859950. IPD Sharing: NO. Countries: 1. Publications: 1.
Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)
ClinicalTrials.gov study NCT02688985. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Mechanism Underlying Beta-cell Failure in Obese African Americans With History of Hyperglycemic Crises
ClinicalTrials.gov study NCT00753142. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mechanism of Gastric Signet Ring Cell Carcinoma Based on Microproteomics
ClinicalTrials.gov study NCT05985577. IPD Sharing: NO. Countries: 1. Publications: 5.
Evaluating Mechanically Engineered Stem Cell Exosomes for Treating Endometrial Injury: A Clinical Study
ClinicalTrials.gov study NCT06896747. IPD Sharing: YES. Countries: 1. Publications: 6.
Study on the Efficacy and Mechanism of Cardiac Rehabilitation for Stem Cell Mobilization and Heart Failure Improvement
ClinicalTrials.gov study NCT00154466. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A B cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation
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Gigantic animal cells suggest organellar scaling mechanisms across a 50-fold range in cell volume
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Data from: ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of Septate Junction integrity in Drosophila epithelial cells
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Data from: Extracellular carbonic anhydrase activity promotes a carbon concentration mechanism in metazoan calcifying cells
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The weaken-fill-repair model for cell budding: Linking cell wall biosynthesis with mechanics
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Molecular mechanism of SNHG11 in human osteosarcoma cells
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Dataset related to article "Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism."
<p>BACKGROUND:</p> <p>Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and aggressive anaplastic carcinoma. Inflammation plays a critical role in thyroid tumors. Conditions predisposing to cancer, as well as oncogene activity, contribute to the construction of an inflammatory microenvironment that facilitates thyroid tumor progression. Moreover, oncogene-induced senescence, a mechanism tightly connected with inflammation, and able to restrain or promote cancer progression, is involved in thyroid cancer. The interactions between thyroid tumor cells and the microenvironment are not completely clarified.</p> <p>METHODS:</p> <p>We characterize in vitro the interplay between macrophages and senescent thyrocytes and tumor-derived cell lines, modeling early and late thyroid tumor stages, respectively. Purified peripheral blood-derived human monocytes were exposed to thyroid cell-derived conditioned medium (CM) and assessed for phenotype by flow cytometry. The factors secreted by thyroid cells and macrophages were identified by gene expression analysis and ELISA. The protumoral effect of macrophages was assessed by wound healing assay on K1 thyroid tumor cells. The expression of PTGS2 and M2 markers in thyroid tumors was investigated in publicly available datasets.</p> <p>RESULTS:</p> <p>Human monocytes exposed to CM from senescent thyrocytes and thyroid tumor cell lines undergo M2-like polarization, showing high CD206 and low MHC II markers, and upregulation of CCL17 secretion. The obtained M2-like macrophages displayed tumor-promoting activity. Among genes overexpressed in polarizing cells, we identified the prostaglandin-endoperoxide synthase enzyme (PTGS2/COX-2), which is involved in the production of prostaglandin E2 (PGE2). By using COX-2 inhibitors we demonstrated that the M2-like polarization ability of thyroid cells is related to the production of PGE2. Co-expression of PTGS2 and M2 markers is observed a significant fraction of human thyroid tumors.</p> <p>CONCLUSIONS:</p> <p>Our results demonstrate that both senescent thyrocytes and thyroid tumor cell lines trigger M2-like macrophage polarization that is related to PGE2 secretion. This suggests that the interaction with the microenvironment occurs at both early and late thyroid tumor stages, and favors tumor progression. The co-expression of PTGS2 gene and M2 markers in human thyroid carcinoma highlights the possibility to counteract tumor growth through COX-2 inhibition.</p>
Cell mechanics measurements in force mapping AFMBioMed Summer school 2020
<p>A 15 min video tutorial to perform AFM cell mechanics measurements in force mapping mode.</p> <p>The video presents:</p> <ul> <li>Preparation of the sample</li> <li>Cantilever coating and calibration </li> <li>Laser alignment and approach</li> <li>How to perform force curves and force maps on living adherent cells</li> </ul>
Rapid mechanical stimulation of inner-ear hair cells by photonic pressure
<p>Hair cells, the receptors of the inner ear, detect sounds by transducing mechanical vibrations into electrical signals. From the top surface of each hair cell protrudes a mechanical antenna, the hair bundle, which the cell uses to detect and amplify auditory stimuli, thus sharpening frequency selectivity and providing a broad dynamic range. Current methods for mechanically stimulating hair bundles are too slow to encompass the frequency range of mammalian hearing and are plagued by inconsistencies. To overcome these challenges, we have developed a method to move individual hair bundles with photonic force. This technique uses an optical fiber whose tip is tapered to a diameter of a few micrometers and endowed with a ball lens to minimize divergence of the light beam. Here we describe the fabrication, characterization, and application of this optical system and demonstrate the rapid application of photonic force to vestibular and cochlear hair cells.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.