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548 results for “DNA repair”
Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair
ClinicalTrials.gov study NCT03318445. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Long term effects of superoxide and DNA repair on lizard telomeres
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Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby
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Data from: Topological DNA-binding of SMC-like RecN promotes RecA-mediated DNA double-strand break repair
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NGS data from: Predominant HDR-dependent genome editing and prevention of byproducts by DNA repair pathway choice
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Data from: A trade-off between oxidative stress resistance and DNA repair plays a role in the evolution of elevated mutation rates in bacteria
The dominant paradigm for the evolution of mutator alleles in bacterial populations is that they spread by indirect selection for linked beneficial mutations when bacteria are poorly adapted. In this paper, we challenge the ubiquity of this paradigm by demonstrating that a clinically important stressor, hydrogen peroxide, generates direct selection for an elevated mutation rate in the pathogenic bacterium Pseudomonas aeruginosa as a consequence of a trade-off between the fidelity of DNA repair and hydrogen peroxide resistance. We demonstrate that the biochemical mechanism underlying this trade-off in the case of mutS is the elevated secretion of catalase by the mutator strain. Our results provide the first experimental evidence that direct selection can favour mutator alleles in bacterial populations, and pave the way for future studies to understand how mutation and DNA repair are linked to stress responses and how this impacts the evolution of bacterial mutation rates.
Utilizing insights of DNA repair machinery to discover MMEJ deletions and novel mechanisms
<p><span>We developed Del-read, an algorithm targeting medium-sized deletions (6-100 bp) in short-reads, which are challenging for current variant callers relying on alignment. Our focus was on Micro-Homolog mediated End Joining deletions (MMEJ-dels), prevalent in myeloid malignancies. MMEJ-dels follow a distinct pattern, occurring between two homologies, allowing us to generate a comprehensive list of MMEJ-dels in the exome. Using Del-read, we identified numerous novel germline and somatic MMEJ-dels in BEAT- AML and TCGA-breast datasets. Validation in 672 healthy individuals confirmed their presence. These novel MMEJ-dels were linked to genomic features associated with replication stress, like G-quadruplexes and minisatellite. <a name="_Hlk170686758"></a>Additionally, we observed a new category of MMEJ-dels with an imperfect match at the flanking sequences of the homologies, suggesting a mechanism involving mispairing in homology alignment. We demonstrated robustness of the repair system despite CRISPR-Cas9-induced mismatches in the homologies. Further analysis of the canonical ASXL1 deletion revealed a diverse array of these imperfect matches. This suggests a potentially more flexible and error-prone MMEJ repair system than previously understood. Our findings highlight Del-read's potential in uncovering previously undetected deletions and deepen our understanding of repair mechanisms.</span></p>
A Trial of Niraparib in Platinum-Sensitive Castration-Resistant Prostate Cancer with DNA Repair Defects
ClinicalTrials.gov study NCT04288687. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Docetaxel and Carboplatin for Patients With mCRPC and DNA-Repair Deficiencies
ClinicalTrials.gov study NCT02985021. IPD Sharing: NO. Countries: 1. Publications: 0.
Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations
ClinicalTrials.gov study NCT04042831. IPD Sharing: Not stated. Countries: 1. Publications: 0.
To Evaluate and Compare p53 Epidermal Expression in Healthy Volunteers 3 Months After Treatment With a 2,940-nm Fractional Ablative Erbium Laser and Topical DNA Repair Enzymes
ClinicalTrials.gov study NCT04277949. IPD Sharing: NO. Countries: 0. Publications: 11.
RP-3500 and Olaparib in DNA Damage Repair Pathway Deficient Relapsed/Refractory Chronic Lymphocytic Leukemia
ClinicalTrials.gov study NCT05405309. IPD Sharing: NO. Countries: 1. Publications: 0.
Pembrolizumab in Metastatic Castration Resistant Prostate Cancer (mCRPC) With or Without DNA Damage Repair Defects
ClinicalTrials.gov study NCT03248570. IPD Sharing: NO. Countries: 1. Publications: 0.
European Trial on Enhanced DNA Repair Inhibition in Ovarian Cancer
ClinicalTrials.gov study NCT03783949. IPD Sharing: Not stated. Countries: 5. Publications: 0.
Data from: A trade-off between oxidative stress resistance and DNA repair plays a role in the evolution of elevated mutation rates in bacteria
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RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a novel role for RAD51 in innate immune response signaling. Defects in RAD51 lead to the accumulation of self-DNA in the cytoplasm triggering a STING-mediated innate immune response after replication stress and DNA damage. Our data suggest that in addition to playing roles in homologous recombination-mediated DNA double-strand break repair and replication fork processing RAD51 is also implicated in the suppression of innate immunity. Thus our study reveals a previously uncharacterized role of RAD51 in initiating immune signaling placing it at the hub of new interconnections between DNA replication DNA repair and immunity. Overall design Gene expression analysis of WT and sh RAD51 HT1080 cells was carried out before and after 1 Gy of high LET Fe particle radiation.
Targeted DNA methylation of the ALS/FTD gene C9orf72 via endogenous DNA damage repair pathways (II)
GEO Series GSE134995. Homo sapiens. 8 samples. Type: Methylation profiling by genome tiling array.
Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency [LAM-HTGTS for MEC-1 cell]
GEO Series GSE310346. Homo sapiens. 37 samples. Type: Other.
Genome-wide profiling of DNA repair proteins in single cells
GEO Series GSE229874. Homo sapiens. 55 samples. Type: Other; Genome binding/occupancy profiling by high throughput sequencing.
Mutations in EGFR compromise hypoxia associated radiation resistance through impaired repair of replication fork associated DNA double-strand breaks
GEO Series GSE95564. Homo sapiens. 12 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.