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Fig. 3 in The Alvarez impact theory of mass extinction; limits to its applicability and the "great expectations syndrome"
Fig. 3. Extraterrestrial elemental proxy Ir, and supplementary Ni, against other geochemical markers in the F–F boundary beds at Kowala, Holy Cross Mountains (after Racki et al. 2002: fig. 8; used with permission from Elsevier); Ir values from an unpublished report (dated 2004) by Yuichi Hatsukawa and Mohammad Mahmudy Gharaie; Ni contents from Racka (1999: table 2); for other data see references in Racki et al. (2011).
Fig. 2 in The Alvarez impact theory of mass extinction; limits to its applicability and the "great expectations syndrome"
Fig. 2. Crater temporal distribution, with possible record at the F–F boundary (A), plotted against Devonian biodiversity losses in terms of substages (B), data from Bambach 2006: fig. 1 (used with permission from the Annual Review of Earth and Planetary Sciences, Volume 34 © 2006 by Annual Reviews, http://www.annualreviews.org.), re−arranged according to the timescale of Kaufman (2006; see the updated tiiming in Becker et al. 2012; Fig. 4); the reconstructed middle Frasnian Alamo crater is also shown to reveal low biodiversity loss in that time (arrowed), as well as the controversial Woodleigh impact structure (see Fig. 5) and the biostratigraphically dated Flynn Creek submarine crater (Schieber and Over 2005). Vertical lines correspond to possible temporal ranges. Abbreviations: Carb., Carboniferous; Givet., Givetian; Lochk., Lochkovian; Prag., Pragian; Silur, Silurian.
Fig. 1 in The Alvarez impact theory of mass extinction; limits to its applicability and the "great expectations syndrome"
Fig. 1. Scheme of the three successive levels in the testing process, encompassing application of the Alvarez impact theory of mass extinction, and possible errors resulting from the "great expectations syndrome" (sensu Tsujita 2001).
Fig. 6 in The Alvarez impact theory of mass extinction; limits to its applicability and the "great expectations syndrome"
Fig. 6. The Late Triassic cratering record plotted against extinction events (based on Lucas and Tanner 2008: fig. 8; crater dates modified after Schmieder and Buchner 2008 and Martin Schmieder personal communication, 2011) and two alternative time scales. Note that the 100 km−sized and precisely dated Manicouagan crater (214.56±0.05 Ma; see ottawa−rasc.ca/wiki/index.php?title=Odale−Articles− Manicouagan) is within the age range of the end−Carnian extinction only in the ICS 2009 geochronologic scheme (see also Lucas et al. 2012). Carbon isotope events compiled from Tanner (2010) and Ruhl and Kürschner (2011: fig.1). Vertical lines correspond to possible temporal ranges. J., Jurassic.
Fig. 3 in Decompression syndrome and diving behavior in Odontochelys, the first turtle
Fig. 3. Enface view of right proximal humeral articular surface of Odontochelys semitestacea Li, Wu, Rieppel, Wang, and Zhao, 2008 from the Lower Carnian (Upper Triassic) Wayao Member of the Falang Formation; Guanling, Guizhou Province, southwest China (IVPP V 13240). Irregular defect (arrow) is characteristic for the avascular necrosis found with decompression syndrome.
Fig. 2 in Decompression syndrome and diving behavior in Odontochelys, the first turtle
Fig. 2. Enface view of left proximal humeral articular surface of Odontochelys semitestacea Li, Wu, Rieppel, Wang, and Zhao, 2008 from the Lower Carnian (Upper Triassic) Wayao Member of the Falang Formation; Guanling, Guizhou Province, southwest China (IVPP V 13240). Irregular defect (arrow) is characteristic for the avascular necrosis found with decompression syndrome.
Fig. 1 in Decompression syndrome and diving behavior in Odontochelys, the first turtle
Fig. 1. Ventral view of anterior body of Odontochelys semitestacea Li, Wu, Rieppel, Wang, and Zhao, 2008 from the Lower Carnian (Upper Triassic) Wayao Member of the Falang Formation; Guanling, Guizhou Province, southwest China (IVPP V 13240). Defects are present on proximal humeral articular surfaces.
Replication Data For: Spiking patterns in the globus pallidus highlight convergent neural dynamics across diverse genetic dystonia syndromes
<div><strong>Human Globus Pallidum Single-Unit Activity Dataset in Genetic Dystonia Patients</strong></div> <div> </div> <div>This dataset consists of tabular data encompassing diverse neural features extracted from spiking trains of stable single-unit activity. These units were isolated from raw microelectrode recordings obtained from the globus pallidum of genetic dystonia patients who underwent globus pallidus internal (GPi) deep brain stimulation (DBS) surgery. The dataset includes anonymized patient IDs, details about the patient's genetic dystonia mutation, as well as information on the hemisphere and depth of microelectrode recordings (MER). Additionally, it features neural properties such as firing rate, spiking regularity, neural bursts, oscillations, and pause characteristics of isolated single-unit activities (SUAs).</div> <div> </div> <div>To process the raw MER, we applied a semi-parametric offline spike sorting algorithm to isolate SUAs. The SUAs were analyzed both in the temporal and frequency domains to derive a comprehensive set of features related to spiking patterns.</div> <div> </div> <div>For those interested in replicating or understanding the feature extraction process, the MATLAB source code is available in the <a href="github.com/ahmetofficial/Spike-Feature-Generator">Github repository</a>.</div>
Dataset related to article "Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin"
<p><em>The file contains raw data related to the article "Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin", available from </em><a href="https://doi.org/10.1016/j.neuropharm.2020.108221">https://doi.org/10.1016/j.neuropharm.2020.108221</a><em>.</em></p> <p> </p> <p><strong>Abstract of the manuscript</strong></p> <p> Motor skill is a specific area of disability of Rett syndrome (RTT), a rare disorder occurring almost exclusively in girls, caused by loss-of-function mutations of the X-linked methyl-CpG-binding protein2 (MECP2) gene, encoding the MECP2 protein, a member of the methyl-CpG-binding domain nuclear proteins family. Brain 5-HT, which is defective in RTT patients and Mecp2 mutant mice, regulates motor circuits and SSRIs enhance motor skill learning and plasticity. In the present study, we used heterozygous (Het) Mecp2 female and Mecp2-null male mice to investigate whether fluoxetine, a SSRI with pleiotropic effects on neuronal circuits, rescues motor coordination deficits. Repeated administration of 10 mg/kg fluoxetine fully rescued rotarod deficit in Mecp2 Het mice regardless of age, route of administration or pre-training to rotarod. The motor improvement was confirmed in the beam walking test while no effect was observed in the hanging-wire test, suggesting a preferential action of fluoxetine on motor coordination. Citalopram mimicked the effects of fluoxetine, while the inhibition of 5-HT synthesis abolished the fluoxetine-induced improvement of motor coordination. Mecp2 null mice, which responded poorly to fluoxetine in the rotarod, showed reduced 5-HT synthesis in the prefrontal cortex, hippocampus and striatum, and reduced efficacy of fluoxetine in raising extracellular 5-HT as compared to female mutants. No sex differences were observed in the ability of fluoxetine to desensitize 5-HT<sub>1A</sub> autoreceptors upon repeated administration. These findings indicate that fluoxetine rescues motor coordination in Mecp2 Het mice through its ability to enhance brain 5-HT and suggest that drugs enhancing 5-HT neurotransmission may have beneficial effects on motor symptoms of RTT.</p>
Data from: Additive effects of developmental acclimation and physiological syndromes on lifetime metabolic and water loss rates of a dry-skinned ectotherm
<p>Data sets from the paper: "Additive effects of developmental acclimation and physiological syndromes on lifetime metabolic and water loss rates of a dry-skinned ectotherm" by Dezetter et al. in Functional Ecology.</p> <p> </p> <p> </p>
Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children
<p>Code and data for the manuscript "Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children" to be published in Cell Reports Medicine.</p> <p>Contains all code located at <a href="https://github.com/lasalletj/COVID_Neutrophils">https://github.com/lasalletj/</a><a href="https://github.com/lasalletj/Pediatric_COVID_MISC_Neutrophils">Pediatric_COVID_MISC_Neutrophils</a> as well as additional data files needed to run the code and supplementary materials for the manuscript.</p> <p>Any additional information required to reanalyze the data reported in this work paper is available from the Lead Contact, Lael Yonker (lyonker@mgh.harvard.edu) upon request.</p>
Data for: Eco-evolutionary consequences of dispersal syndromes during colonization in a passerine bird
<p>In most animal species, dispersing individuals possess phenotypic attributes that mitigate the costs of colonization and/or increase settlement success in new areas ('dispersal syndromes'). This phenotypic integration likely affects population dynamics and the direction of selection, but data are lacking for natural populations. Using an approach that combines population dynamics, quantitative genetics and phenotypic selection analyses, we reveal the existence of dispersal syndromes in a pied flycatcher (<em>Ficedula</em> <em>hypoleuca</em>) population in The Netherlands: immigrants were larger, tended to have darker plumage, bred earlier and produced larger clutches than local recruits, and some of these traits were genetically correlated. Over time, the phenotypic profile of the population gradually changed: each generation advanced arrival and breeding and exhibited longer wings as the result of direct and indirect selection on these correlated traits. Although phenotypic attributes of immigrants were favored by selection during the early phase of colonization, observed phenotypic changes were similar for immigrants and local recruits. We propose that immigrants facilitated initial population establishment but that temporal changes likely resulted from climate change-induced large-scale selection. This study highlights that newly established populations are of non-random composition and that phenotypic architecture affects evolutionary population trajectories. </p>
Database research on the performance of Brazilian teachers in the pandemic and the burnout syndrome
<p>The research developed at the Federal University of Santa Catarina aimed to analyze the levels of Burnout Syndrome in teaching activities during the pandemic, seeking to identify factors, conditions and levels of education that could be associated. Burnout Syndrome is associated with professional activity including exhaustion, emotional exhaustion, chronic stress and dehumanization. The research foresees two procedures for data collection. At first, the instrument was built and validated with specialists. The questionnaire applied online included sociodemographic questions and health conditions, as well as personal and institutional conditions for acting as a teacher during the pandemic and includes the adaptation of a standardized instrument on Burnout Syndrome.</p>
Dataset related to: Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome
<p>The files contain all the dataset included in the manuscript, divided by figure in each tab.</p> <p> </p> <p><strong>Abstract</strong></p> <p>Shiga toxin (Stx)-producing <em>Escherichia coli</em> is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis and acute kidney injury possibly leading to long-term renal sequelae. We previously showed that C3a has a critical role in the development of glomerular damage in experimental HUS. Based on the evidence that activation of C3a/C3a receptor (C3aR) signaling induces mitochondrial dysregulation and cell injury, here we investigated whether C3a caused podocyte and tubular injury through induction of mitochondrial dysfunction in a mouse model of HUS. Mice coinjected with Stx2/LPS exhibited glomerular podocyte and tubular C3 deposits and C3aR overexpression associated with cell damage, which were limited by C3aR antagonist treatment. C3a promoted renal injury by affecting mitochondrial wellness as demonstrated by data showing that C3aR blockade reduced mitochondrial ultrastructural abnormalities and preserved mitochondrial mass and energy production. In cultured podocytes and tubular cells, C3a caused altered mitochondrial fragmentation and distribution, and reduced anti-oxidant SOD2 activity. Stx2 potentiated the responsiveness of renal cells to the detrimental effects of C3a through increased C3aR protein expression. These results indicate that C3aR may represent a novel target in Stx-associated HUS for the preservation of renal cell integrity through the maintenance of mitochondrial function.</p>
Background rates literature review and visualization for Guillain Barré Syndrome (GBS)
<p>Background rates literature review spreadsheet and visualization in forest plots for Guillain Barré Syndrome (GBS)</p>
Seed dispersal syndrome predicts ethanol concentration of fruits in a tropical dry forest
<p><span>Studying fruit traits and their interactions with seed dispersers can improve how we interpret patterns of biodiversity, ecosystem function, and evolution. Mounting evidence suggests that fruit ethanol is common, variable, and may exert selective pressures on seed dispersers. To test this, we comprehensively assess fruit ethanol content in a wild ecosystem and explore sources of variation. We hypothesise that both phylogeny and seed dispersal syndrome explain variation in ethanol levels, and we predict that fruits with mammalian dispersal traits will contain higher levels of ethanol than those with bird dispersal traits. We measured ripe fruit ethanol content in species with mammal- (n = 16), bird- (n = 14), or mixed-dispersal (n = 7) syndromes in a Costa Rican tropical dry forest. Seventy-eight percent of fruit species yielded measurable ethanol concentrations. We detected a phylogenetic signal in maximum ethanol levels (Pagel's λ = 0.82). Controlling for phylogeny, we observed greater ethanol concentrations in mammal-dispersed fruits, indicating that dispersal syndrome helps explain variation in ethanol content and that mammals may be more exposed to ethanol in their diets than birds. Our findings further our understanding of wild fruit ethanol and its potential role as a selective pressure on frugivore sensory systems and metabolism.</span></p>
Myelodysplastic Syndromes (MDS) Event Free Survival With Iron Chelation Therapy Study
ClinicalTrials.gov study NCT00940602. IPD Sharing: YES. Countries: 16. Publications: 1.
Safety and Efficacy of VAY736 in Patients With Primary Sjogren's Syndrome (pSS)
ClinicalTrials.gov study NCT02962895. IPD Sharing: YES. Countries: 19. Publications: 1.
Long-term Safety and Efficacy Study of Teduglutide in Pediatric Participants With Short Bowel Syndrome (SBS)
ClinicalTrials.gov study NCT02954458. IPD Sharing: NO. Countries: 6. Publications: 0.
Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER St
ClinicalTrials.gov study NCT04216589. IPD Sharing: YES. Countries: 2. Publications: 2.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.