Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
112
datasets available to search
ShareScore release 0.7.1
Dataset results
112 results for “E3 Ligase”
Downregulation of the Ubiquitin-E3 Ligase KPC1 promotes glioblastoma progression through upregulation of SerpinE1 [RNA-seq]
GEO Series GSE131400. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability
GEO Series GSE262951. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
EGFR is a target of the tumor suppressor E3-ligase FBXW7
GEO Series GSE246896. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Accurate stress response silencing by an E3 ligase complex mutated in neurodegenerative disease
GEO Series GSE232191. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Deletion of KLHDC3, an E3 ubiquitin ligase complex substrate receptor, leads to obesity in mice
GEO Series GSE271979. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Somatic deficiency of human E3 ubiquitin ligase CBL in leukocytes Impairs B cell but not T cell development and function
GEO Series GSE307131. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Rescue of HIF1A protein level by E3-ligase KO
GEO Series GSE228311. Homo sapiens. 9 samples. Type: Other.
The Arabidopsis NOT4A E3 ligase promotes PGR3 expression and regulates chloroplast translation
GEO Series GSE161571. Arabidopsis thaliana. 6 samples. Type: Expression profiling by high throughput sequencing.
The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8+ T Cells
GEO Series GSE213921. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing; Other.
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders via chemical genetics
GEO Series GSE198280. Homo sapiens. 45 samples. Type: Other.
Identification of Factors Required for m6A mRNA Methylation in Arabidopsis Reveals a Role for the Conserved E3 Ubiquitin Ligase HAKAI
GEO Series GSE97174. Arabidopsis thaliana. 6 samples. Type: Expression profiling by high throughput sequencing.
E3 SUMO ligase PIAS3 fine-tunes dorsoventral patterning and visual response of cones in the mouse retina but is not essential for photoreceptor cell fate specification
GEO Series GSE94011. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes
GEO Series GSE144298. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Data from: The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner
Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. Additionally, obesity and type 2 diabetes are characterized by chronic low-grade inflammation. Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase best known for suppression of antigen presentation by dendritic and B cells. MARCH1 was recently found to negatively regulate the cell surface levels of the insulin receptor via ubiquitination. This, in turn, impaired insulin sensitivity in mouse models. Here, we report that MARCH1-deficient (knockout; KO) female mice exhibit excessive weight gain and excessive visceral adiposity when reared on standard chow diet, without increased inflammatory cell infiltration of adipose tissue. By contrast, male MARCH1 KO mice had similar weight gain and visceral adiposity to wildtype (WT) male mice. MARCH1 KO mice of both sexes were more glucose tolerant than WT mice. The levels of insulin receptor were generally higher in insulin-responsive tissues (especially the liver) from female MARCH1 KO mice compared to males, with the potential to account in part for the differences between male and female MARCH1 KO mice. We also explored a potential role for MARCH1 in human type 2 diabetes risk through genetic association testing in publicly-available datasets, and found evidence suggestive of association. Collectively, our data indicate an additional link between immune function and diabetes, specifically implicating MARCH1 as a regulator of lipid metabolism and glucose tolerance, whose function is modified by sex-specific factors.
Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participant
ClinicalTrials.gov study NCT06896916. IPD Sharing: YES. Countries: 7. Publications: 0.
Rhamnogalacturonan Lyase 1 (RGL1), as a suppressor of E3 ubiquitin ligase Arabidopsis thaliana Ring Zinc Finger 1 (AtRZF1), is involved in dehydration response to mediate proline synthesis and pectin
GEO Series GSE266158. Arabidopsis thaliana. 9 samples. Type: Expression profiling by high throughput sequencing.
The SUMO E3 ligase-like proteins PIAL1 and PIAL2 interact with MOM1 and form a novel complex required for transcriptional silencing [RNA-seq]
GEO Series GSE80301. Arabidopsis thaliana. 8 samples. Type: Expression profiling by high throughput sequencing.
Combinatorial mapping of E3 ubiquitin ligases to their target substrates
GEO Series GSE234621. Escherichia coli; Homo sapiens. 98 samples. Type: Other.
Downregulation of the Ubiquitin-E3 Ligase KPC1 promotes glioblastoma progression through upregulation of SerpinE1
GEO Series GSE131402. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Protein profiling by protein array.
Data from: The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.