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ShareScore release 0.9.0
Dataset results
93 results for “EPO”
Pre-established chromatin interactions mediate acute transcriptional response to Epo
GEO Series GSE142006. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic proxy for EPO-increasing therapies.
<p>Summary statistics for the genome-wide association study meta-analysis of circulating EPO in 6,127 individuals of European and African American descent. Effect sizes are aligned to allele 1. </p> <p>Description of column names:<br> # Marker - this is the marker name; chromosome:position<br> # Allele1 - the first allele for this marker in the first file where it occurs<br> # Allele2 - the second allele for this marker in the first file where it occurs<br> # Freq1 - weighted average of frequency for allele 1 across all studies<br> # FreqSE - corresponding standard error for allele frequency estimate<br> # MinFreq - minimum frequency for allele 1 across all studies<br> # MaxFreq - maximum frequency for allele 1 across all studies<br> # Effect - overall estimated effect size for allele1<br> # StdErr - overall standard error for effect size estimate<br> # P-value - meta-analysis p-value<br> # Direction - summary of effect direction for each study, with one '+' or '-' per study. Order of the studies is InCHIANTI, BLSA, HealthABC Europeans, PREVEND, HealthABC African Americans<br> # HetISq - I^2 statistic which measures heterogeneity on scale of 0-100%<br> # HetChiSq - chi-squared statistic in simple test of heterogeneity<br> # df - degrees of freedom for heterogeneity statistic<br> # HetPVal - P-value for heterogeneity statistic<br> # TotalSampleSize - overall sample size for that variant in the meta-analysis</p> <p> </p>
Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic proxy for EPO-increasing therapies.
<p>Raw fast-qc files for RNA sequencing analysis of whole <em>EPO</em> gene knock-outs generated through CRISPR-Cas9 gene-editing in HEK-293 cells compared to wild-type controls. </p> <p>Wild-type cell-lines (Empty 1 - Empty 4) were transfected with empty CRISPR-Cas9 constructs to ensure cells were treated under the same experimental conditions. Whole EPO gene knock-outs were generated using a double gRNA approach with CRISPR-Cas9 gene-targeting. Two whole EPO gene knock-out cell-lines were generated (KO-A and KO-B).</p> <p>Library preparation was performed using the TruSeq DNA HT Library Preparation Kit using the 3’ poly-A tail primer Oligo(dT) from Illumina (Illumina, California, USA). RNA Sequencing was performed using the Illumina HiSeq 2500 high-throughput sequencing system (Illumina, California, USA). We resulted in 75 bp paired-end sequences.</p> <p> </p>
Improvement of EPO-resistance in Hemodialysis Patients With Chronic Inflammation by High Cut-off Hemodialysis
ClinicalTrials.gov study NCT01526798. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Darbepoetin in Patients Candidates for Liver Transplant. (EPO-LT Trial)
ClinicalTrials.gov study NCT07169643. IPD Sharing: NO. Countries: 1. Publications: 0.
Assesment of a Predictive Model Dosage of EPO in Hemodialysis Patients
ClinicalTrials.gov study NCT02337335. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety Study of Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Traumatic Brain Injury: Dosing Tier 1
ClinicalTrials.gov study NCT01239706. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS)
ClinicalTrials.gov study NCT00234143. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety & Efficacy of EPO-018B for the Treatment of Anemia in Participants With ERSD Receiving Maintenance Hemodialysis
ClinicalTrials.gov study NCT02366325. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Renal Graft Function After Treatment With Erythropoietin (EPO)
ClinicalTrials.gov study NCT01450878. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sponge and Eosinophil Peroxidase (EPO) Staining
ClinicalTrials.gov study NCT03078023. IPD Sharing: NO. Countries: 1. Publications: 0.
EVR and EPO for Liver Transplant Tolerance
ClinicalTrials.gov study NCT06832189. IPD Sharing: YES. Countries: 1. Publications: 0.
REGENESIS (CA): A Study of NTx™-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients
ClinicalTrials.gov study NCT00663416. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Therapeutic Education of Chronic Renal or Renal Transplant Patient in the Management of EPO Injections
ClinicalTrials.gov study NCT03481686. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of APC and Epo on the Inflammatory Response During Sepsis
ClinicalTrials.gov study NCT00229034. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of PEG-EPO Injection (CHO Cells) for Maintenance Therapy of Patients With Renal Anemia .
ClinicalTrials.gov study NCT05629598. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exosome Proteomics to Detect EPO
ClinicalTrials.gov study NCT03700515. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Evaluation of Tolerability and Efficacy of Erythropoietin (EPO) Treatment in Spinal Shock: Comparative Study Versus Methylprednisolone (MP)
ClinicalTrials.gov study NCT00561067. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study)
ClinicalTrials.gov study NCT02376881. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Study of HM10760A (Long-acting Erythropoietin (EPO)) in Healthy Korean Subjects
ClinicalTrials.gov study NCT01013064. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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