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ShareScore release 0.9.0
Dataset results
83 results for “Growth plates”
Premature aging in growth-plate and periosteum resident skeletal stem cells is responsible for bone loss
GEO Series GSE182540. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes [MBD-seq]
GEO Series GSE270641. Mus musculus. 6 samples. Type: Methylation profiling by high throughput sequencing.
TET1 KO affects Sox9 function [growth plate tissue]
GEO Series GSE105121. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Cholesterol biosynthesis and mutant IDH activity are linked to cellular glycogen through PPP1R3C in growth plate chondrocytes and chondrosarcoma [RNA-seq]
GEO Series GSE286965. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Data from: Resting zone of the growth plate harbors a unique class of skeletal stem cells
Skeletal stem cells regulate bone growth and homeostasis by generating diverse cell types including chondrocytes, osteoblasts and marrow stromal cells. The emerging model postulates a distinct type of skeletal stem cells closely associated with the growth plate1-4, a special cartilaginous tissue playing critical roles in bone elongation5. The resting zone maintains the growth plate by expressing parathyroid hormone-related protein (PTHrP) that interacts with Indian hedgehog (Ihh) released from the hypertrophic zone6-10, while providing a source of other chondrocytes11. However, the identity of skeletal stem cells and how they are maintained in the growth plate are unknown. Here we show that skeletal stem cells are formed among PTHrP+ chondrocytes within the resting zone of the postnatal growth plate. PTHrP+ chondrocytes expressed a panel of markers for skeletal stem/progenitor cells and uniquely possessed the properties as skeletal stem cells in cultured conditions. Cell lineage analysis revealed that PTHrP+ resting chondrocytes continued to form columnar chondrocytes long term, which underwent hypertrophy and became osteoblasts and marrow stromal cells beneath the growth plate. Transit-amplifying chondrocytes in the proliferating zone, which was concertedly maintained by a forward signal from undifferentiated cells (PTHrP) and a reverse signal from hypertrophic cells (Ihh), provided instructive cues to maintain cell fates of PTHrP+ resting chondrocytes. Our findings unravel a unique somatic stem cell type that is initially unipotent and acquires multipotency at the post-mitotic stage, underscoring the malleable nature of the skeletal cell lineage. This system provides a model in which functionally dedicated stem cells and their niche are specified postnatally and maintained throughout tissue growth by a tight feedback regulation system.
MRI Findings of Epiphyseal Growth Plate in Healthy Children
ClinicalTrials.gov study NCT03190200. IPD Sharing: NO. Countries: 1. Publications: 0.
Diffusion MRI and Growth Plate Injuries: Pilot Study
ClinicalTrials.gov study NCT01774539. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinico-biological Collection of Bone, Calcium and Growth Plate Pathologies
ClinicalTrials.gov study NCT06444503. IPD Sharing: NO. Countries: 1. Publications: 0.
Molecular Modulation of the Growth Plate
ClinicalTrials.gov study NCT03501589. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Isotretinoin on the Growth Rate and Thickness of the Nail Plate
ClinicalTrials.gov study NCT04660916. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
RSA Study on the Behaviour of the Growth Plate During and After Temporary Hemi-epiphysiodesis and Epiphysiodesis
ClinicalTrials.gov study NCT04235517. IPD Sharing: NO. Countries: 1. Publications: 0.
p21 misexpression in the left growth plates
GEO Series GSE97232. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Data from: Resting zone of the growth plate harbors a unique class of skeletal stem cells
Open the record for dataset details and reuse information.
gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes [bulkRNA-seq]
GEO Series GSE188353. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
High-throughput sequencing analyses of transcript changes in growth plates upon dexamethasone treatment
GEO Series GSE190744. Rattus norvegicus. 24 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Stimulation of skeletal stem cells in the growth plate promotes linear bone growth.
GEO Series GSE254020. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes [scRNA-seq]
GEO Series GSE184406. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Bovine Hypertrophic Growth Plate Chondrocytes vs. Reserve Zone Chondrocytes
GEO Series GSE18738. Bos taurus. 12 samples. Type: Expression profiling by array.
Bulk RNA-seq of articular and growth plate chondrocytes from control and Sox9 mutant mice
GEO Series GSE154381. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Expression data from articular and growth plate cartilage
GEO Series GSE23492. Sus scrofa. 6 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.