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66
datasets available to search
ShareScore release 0.9.0
Dataset results
66 results for “HDAC6”
Immunosuppression induced by brain specific HDAC6 deletion improves motor performance and extends lifespan in Drosophila melanogaster
GEO Series GSE136099. Drosophila melanogaster. 4 samples. Type: Expression profiling by high throughput sequencing.
HDAC6 and HSP90 control the functions of Foxp3+ T regulatory cells
GEO Series GSE27896. Mus musculus. 6 samples. Type: Expression profiling by array.
HDAC6 Inhibition Disrupts HDAC6-P300 Interaction Reshaping the Cancer Chromatin Landscape (ATAC-Seq)
GEO Series GSE273644. Homo sapiens; Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Coordination of Rel Expression by MAP3K4, CBP, and HDAC6 Controls TS cell Phenotype (RNA-seq)
GEO Series GSE148496. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Valine-restricted diet regulates DNA methylation [NLS-HDAC6 TET2 ChIP-Seq]
GEO Series GSE274883. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
KLF9-GRK5-HDAC6 axis aggravates osteoarthritis pathogenesis by promoting chondrocyte extracellular matrix degradation and apoptosis
GEO Series GSE285234. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Liver RNA microarray from female HDAC6–/–, HDAC9–/– mice
GEO Series GSE120797. Mus musculus. 12 samples. Type: Expression profiling by array.
Expression data of liver samples of dex or vehicle treated wildtype and HDAC6- knockout C57Bl/6 mice respectively
GEO Series GSE34229. Mus musculus. 12 samples. Type: Expression profiling by array.
HDAC6 and TDP-43 promote autophagy impairment in Amyotrophic Lateral Sclerosis
<p>The database includes the raw data of the article “HDAC6 and TDP-43 promote autophagy impairment in Amyotrophic Lateral Sclerosis”. Aim of this work was to investigate how TDP-43 and HDAC6 interacts, leading to the impairment of the autophagy pathway. The work was performed in both PBMCs and in transfected SH-SY5Y cells.</p> <p>The database contains the data obtained by the following evaluations: a) western blot (WB) analysis in healthy control and sporadic ALS patients PBMCs b) western blot analysis of protein involved in autophagy pathway after transfection with TDP-43 WT plasmid c) western blot analysis of protein involved in autophagy pathway after silencing of HDAC6.<span> </span></p> <p>This work provides solid evidence supporting the hypothesis that dysregulation of HDAC6 is a key factor in the disruption of the autophagy pathway previously detected in sALS PBMCs. To the best of our knowledge, we demonstrated for the first time that both excessive reduction in acetylated α-tubulin levels, due to HDAC6 overexpression, and excessive increase in acetylated α-tubulin levels, resulting from HDAC6 downregulation, lead to impairments in autophagy. These findings could be exploited as possible therapeutic target.</p>
Tubacin mediates the synthetic lethality of cysteine in breast cancer independent on HDAC6
GEO Series GSE154425. Homo sapiens. 12 samples. Type: Expression profiling by array.
Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma
GEO Series GSE143887. Homo sapiens. 9 samples. Type: Expression profiling by array.
HDAC6 Inhibition Disrupts HDAC6-P300 Interaction Reshaping the Cancer Chromatin Landscape (ChIP-Seq)
GEO Series GSE273645. Mus musculus; Homo sapiens. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Central Inhibition of HDAC6 Re-Sensitizes Leptin Signaling During Obesity to Induce Profound Weight Loss
GEO Series GSE252779. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in pediatric AML [RNA-seq]
GEO Series GSE297366. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of HDAC6-selective and broad HDAC inhibitors in human WT iPSC cardiomyocytes
GEO Series GSE180248. Homo sapiens. 63 samples. Type: Expression profiling by high throughput sequencing.
HDAC6 regulates NF-κB signalling by HDAC-dependent and independent mechanisms to control chondrocyte IL-1-induced MMP and inflammatory gene expression [HDAC siRNA exp]
GEO Series GSE186688. Homo sapiens. 8 samples. Type: Expression profiling by array.
HDAC6 regulates NF-κB signalling by HDAC-dependent and independent mechanisms to control chondrocyte IL-1-induced MMP and inflammatory gene expression [TSA exp]
GEO Series GSE186689. Homo sapiens. 4 samples. Type: Expression profiling by array.
Single-Nucleus RNA Sequencing Reveals HDAC6 Inhibition Reverses Doxorubicin-Induced Cognitive Impairment
GEO Series GSE271055. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Gene expression effects of KDAC6 (HDAC6) knockout in HT1080 cells
GEO Series GSE302329. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in pediatric AML [ATAC-seq]
GEO Series GSE297364. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.