Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
468
datasets available to search
ShareScore release 0.9.0
Dataset results
468 results for “HLA”
HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide
ClinicalTrials.gov study NCT02793544. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Therapeutic Effects of Epstein-Barr Virus Immune T-Lymphocytes Derived From a Normal HLA-Compatible Or Partially-Matched Third-Party Donor in the Treatment of EBV Lymphoproliferative Disorders and EBV
ClinicalTrials.gov study NCT01498484. IPD Sharing: Not stated. Countries: 1. Publications: 1.
T Cell Receptor Immunotherapy Targeting MAGE-A3 for Patients With Metastatic Cancer Who Are HLA-A*01 Positive
ClinicalTrials.gov study NCT02153905. IPD Sharing: NO. Countries: 1. Publications: 3.
Steroid Withdrawal and Donor-specific Anti-HLA Antibodies in Renal Transplant Patients
ClinicalTrials.gov study NCT02284464. IPD Sharing: Not stated. Countries: 1. Publications: 21.
Study to Evaluate the Safety and Efficacy of KITE-439 in HLA-A*02:01+ Adults With Relapsed/Refractory HPV16+ Cancers
ClinicalTrials.gov study NCT03912831. IPD Sharing: NO. Countries: 1. Publications: 0.
Use of Immune Globulin Plus Rituximab for Desensitization in Highly HLA Sensitized Patients Awaiting Deceased Donor Kidney Transplantation
ClinicalTrials.gov study NCT01178216. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from: Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population
Open the record for dataset details and reuse information.
Data for: Endo-lysosomal assembly variations among Human Leukocyte Antigen class I (HLA-I) allotypes
Open the record for dataset details and reuse information.
Data from: Anti-HLA antibodies may be a subset of polyreactive immunoglobulins generated after viral superinfection
Open the record for dataset details and reuse information.
HLA Class II specificity assessed by high-density peptide microarray interactions
Open the record for dataset details and reuse information.
HLA class I Sanger sequences data of Honduras HIV cohort
Open the record for dataset details and reuse information.
Amino acid variation in HLA class II proteins is a major determinant of humoral response to common viruses - GWAS summary results
<p>Online Supplementary Dataset of the manuscript "Amino acid variation in HLA class II proteins is a major determinant of humoral response to common viruses": http://www.cell.com/ajhg/fulltext/S0002-9297(15)00372-9</p>
A molecular basis for the presentation of phosphorylated peptides by HLA-B antigens (ANNOTATED MS2 SPECTRA OF PHOSPHOPEPTIDES)
<p>Phosphopeptides identified from the immunopeptidome of the C1R-B*40 cell line. </p> <p>Phosphopeptides identified from the proteome of the C1R-B*40 cell line. </p> <p>Phosphopeptides identified from the immunopeptidome of the GR cell line. </p>
Molecular Dynamics of HLA-A 02:01 with neoantigen and wild-type peptides from AKP6 and ASTN1 genes.
<p>Molecular Dynamics simulations of 4 complexes :</p> <p>1. Protein HLA-A*02:01 with the wild-type peptide WLIDMESLV from AKP6 gene.</p> <p>2. Protein HLA-A*02:01 with the neoantigen peptide WLIDMKSLV from AKP6 gene.</p> <p>3. Protein HLA-A*02:01 with the neoantigen peptide KLYGLDWAEL from ASTN1 gene.</p> <p>4. Protein HLA-A*02:01 with the wild-type peptide KPYGLDWAEL from ASTN1 gene.</p>
Example of KRAS oncogene mutational regression and HLA haplotype characterization in oligo-metastatic colorectal cancer patient (ID: PAT2)
<p>KRAS oncogene mutational regression from primary tumour to lung metastasis (evaluated through TSO500 panel, Illumina Novaseq 6000 platform) and HLA haplotype characterization (through PCR) in a representative oligo-metastatic colorectal cancer patient (ID: PAT2).</p>
HLA class I and class II allelic profile of healthy Lebanese population
<p class="MsoNormal"><strong><span>Background</span></strong><span>. This study examined the origin of present-day Lebanese using high-resolution HLA class I and class II allele and haplotype distributions. The study subjects comprised 152 unrelated individuals, and their HLA class I and class II alleles and two-locus and five-locus haplotypes were compared with those of neighboring and distant communities </span><span>using genetic distances, neighbor-joining dendrograms, correspondence, and<strong> </strong>haplotype analyses</span><span>. </span><span>HLA class I (<em>A</em>, <em>B</em>, <em>C</em>) and class II (<em>DRB1</em>, <em>DQB1</em>) were genotyped at a high-resolution level by PCR-SSP. </span></p> <p class="MsoNormal"><strong><span>Results</span></strong><span>. In total, 76 alleles across the five HLA loci were detected: <em>A*03:01</em> (17.1%), <em>A*24:02</em> (16.5%), <em>B*</em></span><em><span>35:01</span></em><span> (25.7%), <em>C*</em></span><em><span>04:01</span></em><span> (25.3%), and </span><em><span>C*</span></em><em><span>07:01</span></em><span> (20.7%) were t</span><span>he most frequent class I alleles, while <em>DRB1*</em></span><em><span>11:01</span></em><span> (34.2%) and <em>DQB1*03:01</em> (43.8%) were the most frequent class II alleles. All pairs of HLA loci were in significant linkage disequilibrium. The most frequent two-locus haplotypes recorded were <em>DRB1*11:01</em></span><span>~</span><em><span>DQB1*03:01</span></em><span> (30.9%), <em>B*35:01</em>-<em>C*04:01</em> (20.7%), <em>B*35:01</em></span><span>~</span><em><span>DRB1*11:01</span></em><span> (13.8%), and <em>A*24:02</em></span><span>~</span><em><span>B*35:01</span></em><span> (10.3%). Lebanese appear to be closely related to East Mediterranean communities such as Levantines (Palestinians, Syrians, and Jordanians), Turks, Macedonians, and Albanians. However, Lebanese appear to be distinct from North African, Iberian, and Sub-Saharan communities. </span></p> <p class="MsoNormal"><strong><span>Conclusions</span></strong><span>. Collectively, this indicates a limited genetic contribution of Arabic-speaking populations </span><span>(from North Africa or the Arabian Peninsula</span><span>) and Sub-Saharan communities to the present-day Lebanese gene pool.</span><strong><span> </span></strong><span>This confirms the notion that Lebanese population are of mixed East Mediterranean and Asian origin, with a marked European component.</span></p>
MHC-wide association results (uveitis-JIA vs non-uveitis JIA) conditioned on serine position 11 in HLA-DRB1
<p>Association results across the major histocompatibility complex (MHC) on chromosome 6, conditioned on serine (S) at position 11 in <em>HLA-DRB1</em>. Note that coordinates are on build hg18. Columns are:</p> <ol> <li>CHR: chromosome</li> <li>SNP: SNP identifier</li> <li>BP: basepair position (hg18)</li> <li>A1: minor allele/tested allele</li> <li>A2: other allele (major allele)</li> <li>FRQ: frequency of the A1 allele</li> <li>INFO: imputation quality info score</li> <li>OR: odds ratio</li> <li>SE: standard error of the t-statistic (note that the t-statistic is not provided in the file)</li> <li>P: p-value of the SNP</li> </ol>
MHC-wide association results (uveitis-JIA vs non-uveitis JIA) conditioned on aspartic acid position 11 in HLA-DRB1
<p>Association results across the major histocompatibility complex (MHC) on chromosome 6, conditioned on aspartic acid (D) at position 11 in <em>HLA-DRB1</em>. Note that coordinates are on build hg18. Columns are:</p> <ol> <li>CHR: chromosome</li> <li>SNP: SNP identifier</li> <li>BP: basepair position (hg18)</li> <li>A1: minor allele/tested allele</li> <li>A2: other allele (major allele)</li> <li>FRQ: frequency of the A1 allele</li> <li>INFO: imputation quality info score</li> <li>OR: odds ratio</li> <li>SE: standard error of the t-statistic (note that the t-statistic is not provided in the file)</li> <li>P: p-value of the SNP</li> </ol>
Snakemake report for manuscript "Orthanq: transparent and uncertainty-aware haplotype quantification with application in HLA-typing"
<p>For viewing the report, unzip the file and open index.html in your browser.</p>
Data from: HLA-G 14 bp variant is associated with exercise-induced oxygen desaturation in the post-COVID-19 condition
<p>The HLA-G molecule has been related to the lung inflammatory process in respiratory diseases. A 14 pb insertion/deletion in the gene encoding HLA-G<em> </em>has been associated with differential levels of the HLA-G molecule in plasma and with the severity of infectious diseases. Therefore, this study evaluates the association of the <em>HLA-G </em>variant 14 pb insertion/deletion (rs371194629) with COVID-19 susceptibility, severity, and oxygen desaturation in the post-COVID condition. We included 621 patients with severe COVID-19 hospitalized in a third-level hospital; 520 subjects Non-COVID (recruited previous to the COVID-19 pandemic); and 101 patients that were followed after discharge of COVID-19 (46.4% presenting exercise-induced oxygen desaturation). The severity of COVID-19 was evaluated through the invasive mechanical ventilation (IMV) requirement. We found that the DD genotype was more frequent among patients requiring IMV than non-IMV (0.372 vs 0.290, p= 0.046, OR =1.45, 95%CI = 1.01-2.08, dominant model). This genotype was also associated with exercise-induced oxygen desaturation in post-COVID patients (0.435 vs 0.196, p=0.011, OR=3.15, CI 95%=1.28-7.79, dominant model). The allele and genotype frequencies were similar when COVID-19 and non-COVID subjects were compared. Thus, the DD genotype of rs371194629 <em>HLA-G </em>was associated with COVID-19 severity and post-COVID condition.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.