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61 results for “Hookworm”
Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
ClinicalTrials.gov study NCT01940757. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Advances in neglected tropical disease vaccines: developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine
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Data from: Unexpected absence of genetic separation of a highly diverse population of hookworms from geographically isolated hosts
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Controlled infection with cryopreserved human hookworm induces CTLA-4 expression on Tregs and upregulates tryptophan metabolism
<p>Human plasma metabolomics dataset generated from controlled human hookworm infection study. <br><br><span>Infecting humans with controlled doses of helminths, such as human hookworm (termed hookworm therapy), is proposed to prevent or treat various intestinal and extraintestinal disease. However, full-scale clinical trials examining hookworm therapy are limited by the inability to scale-up the production of hookworm larvae to infect sufficient numbers of patients. With the aim of overcoming this challenge, this study infected four healthy individuals with hookworm larvae that had been reanimated from cryopreserved eggs, to examine their viability and immunogenicity. We</span><span> demonstrate that reanimated cryopreserved hookworm larvae establish a viable hookworm infection and elicit a similar immune response to larvae cultured from fresh stool. Furthermore, </span><span>a refined understanding of the therapeutic mechanisms of hookworm is imperative to determine which diseases to target with hookworm therapy. To investigate potential therapeutic mechanisms, this study infected 13 healthy individuals with hookworm and assessed changes in the immune cells, microbiome, and metabolome.</span><span> <span>We identified potential immunoregulatory mechanisms by which hookworm may provide a beneficial </span></span><span>effect on its host, including increased expression of CTLA-4 on regulatory T cells (Tregs) and upregulation of tryptophan metabolism. In summary, our findings demonstrate the feasibility of full-scale clinical trials examining hookworm therapy by minimising the reliance on human donors and optimising the culturing process, thereby enabling viable hookworm larvae to be mass-produced and enabling on-demand inoculation of patients. Furthermore, this study provides insights into the complex interactions between helminths and their host, which could inform the development of novel therapeutic strategies.</span></p>
Hookworm of Monkey (Macaca fascicularis) from Alam Damai, Cheras, KL
<p>Hookworm larvae found in the large intestine of Macaca fascicularis, a monkey commonly found in Malaysia. The larvae detected using Harada Mori technique. There were 12 samples but managed to get only one positive sample of larvae.</p> <p> </p>
Data from: Impact of population structure on genetic diversity of a potential vaccine target in the canine hookworm (Ancylostoma caninum)
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Disruption of C5a/C5aR1 axis confers protection against hookworm infection in lung
GEO Series GSE272613. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Human hookworm infection enhances mycobacterial growth inhibition and associates with reduced risk of tuberculosis infection.
GEO Series GSE122737. Homo sapiens. 31 samples. Type: Expression profiling by array.
Gene expression in HT-29-MTX intestinal epithelial cells treated with Ancylostoma ceylanicum hookworm larvae
GEO Series GSE93620. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Data from: Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults
Necator americanus Glutathione-S-Transferase-1 (Na-GST-1) plays a role in the digestion of host hemoglobin by adult N. americanus hookworms. Vaccination of laboratory animals with recombinant Na-GST-1 is associated with significant protection from challenge infection. Recombinant Na-GST-1 was expressed in Pichia pastoris and adsorbed to aluminum hydroxide adjuvant (Alhydrogel) according to current Good Manufacturing Practice. Two Phase 1 trials were conducted in 142 healthy adult volunteers in the United States and Brazil, first in hookworm-naïve individuals and then in residents of a N. americanus endemic area in Brazil. Volunteers received one of three doses of recombinant Na-GST-1 (10, 30, or 100 μg) adjuvanted with Alhydrogel, adjuvanted with Alhydrogel and co-administered with an aqueous formulation of Glucopyranosyl Lipid A (GLA-AF), or the hepatitis B vaccine. Vaccinations were administered via intramuscular injection on days 0, 56, and 112. Na-GST-1/Alhydrogel was well tolerated in both hookworm-naïve and hookworm-exposed adults, with the most common adverse events being mild to moderate injection site pain and tenderness, and mild headache and nausea; no vaccine-related severe or serious adverse events were observed. Antigen-specific IgG antibodies were induced in a dose-dependent fashion, with increasing levels observed after each vaccination in both trials. The addition of GLA-AF to Na-GST-1/Alhydrogel did not result in significant increases in specific IgG responses. In both the US and Brazil studies, the predominant IgG subclass induced against Na-GST-1 was IgG1, with lesser amounts of IgG3. Vaccination of both hookworm-naïve and hookworm-exposed adults with recombinant Na-GST-1 was safe, well tolerated, and resulted in significant antigen-specific IgG responses. Based on these results, this vaccine will be advanced into clinical trials in children and eventual efficacy studies.
Does Treating Hookworm Improve Productivity of Small Subsistence Farmers
ClinicalTrials.gov study NCT02102321. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immune Responses in the Skin After Hookworm Infection
ClinicalTrials.gov study NCT06478498. IPD Sharing: NO. Countries: 1. Publications: 0.
Randomised Controlled Clinical Trials of the Effect of Therapeutic Hookworm Infection in Allergic Rhinoconjunctivitis
ClinicalTrials.gov study NCT00232518. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomised Placebo Controlled Study of Effects of Therapeutic Hookworm Infection in Asthma
ClinicalTrials.gov study NCT00469989. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Hookworm Therapy for Coeliac Disease
ClinicalTrials.gov study NCT02754609. IPD Sharing: NO. Countries: 2. Publications: 0.
Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults
ClinicalTrials.gov study NCT01717950. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mebendazole Study Against Hookworm Infections in Children and Adolescents in Ghana
ClinicalTrials.gov study NCT03261596. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Data from: Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults
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Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung
GEO Series GSE5555. Mus musculus. 42 samples. Type: Expression profiling by array.
Effect of Hookworm Elimination and Vitamin A Intervention on Iron Status of Preschool Children in Sichuan, China
ClinicalTrials.gov study NCT02675140. IPD Sharing: YES. Countries: 0. Publications: 0.
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