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638 results for “Human neurons”
Hedgehog induced oxidative phosphorylation rescues the neuronal differentiation defect of human enteric neural crest cells underlying Hirschsprung disease
<p>Hedgehog induced oxidative phosphorylation rescues the neuronal differentiation defect of human enteric neural crest cells underlying Hirschsprung disease</p>
Data and code related to the manuscript "Perceptual stability reflected in neuronal pattern similarities in human visual cortex" (Broday-Dvir et al.)
<p>This data set contains intracranial EEG data, analysis code and results associated with the manuscript "<strong>Perceptual stability reflected in neuronal pattern similarities in human visual cortex". </strong></p> <p>The code is written in Matlab R2019b. Matlab's Signal Processing Toolbox is required. </p> <p>Files ending with ".mat" are the data files, ".m" files are the associated scripts.</p> <p>Additional open-source toolboxes required to run the codes:</p> <ul> <li><strong>Mass Univariate ERP Toolbox</strong> (<a href="https://openwetware.org/wiki/Mass_Univariate_ERP_Toolbox">https://openwetware.org/wiki/Mass_Univariate_ERP_Toolbox</a>), version: "dmgroppe-Mass_Univariate_ERP_Toolbox-d1e60d4". D. M. Groppe, T. P. Urbach, M. Kutas, Mass univariate analysis of event-related brain potentials/fields I: A critical tutorial review. <em>Psychophysiology</em>. <strong>48</strong>, 1711–1725 (2011).</li> <li><strong>DRtoolbox </strong>(https://lvdmaaten.github.io/drtoolbox/), version: 0.8.1b. L.J.P. van der Maaten, E.O. Postma, and H.J. van den Herik. <strong>Dimensionality Reduction: A Comparative Review</strong>. Tilburg University Technical Report, TiCC-TR 2009-005, 2009.</li> </ul> <p> </p>
Generation of human induced pluripotent stem cells-derived cortical neurons for high throughput imaging of neurite morphology and neuron maturation
<p>Figure 5: Whole cell patch clamping showed the differentiated neurons are functional.</p>
Generation of human induced pluripotent stem cells-derived cortical neurons for high throughput imaging of neurite morphology and neuron maturation
<p>Figure 3 - Neurite outgrowth dataset. Comparing neurite outgrowth at Day1 and 15 post-seeding cortical neural progenitors. </p>
Whole human-brain mapping of single cortical neurons for profiling morphological diversity and stereotypy
<p>Quantifying neuron morphology and distribution at the whole brain scale is essential to understand the structure and diversity of cell types. It is exceedingly challenging to reuse recent technologies of single cell labeling and whole brain imaging to study human brains. We propose Adaptive Cell Tomography (ACTomography), a low-cost, high-throughput, high-efficacy tomography approach, based on adaptive targeting of individual cells. We established a platform to inject dyes into cortical neurons in surgical tissues of 18 patients with brain tumors or other conditions and 1 donated fresh postmortem brain. We collected 3-D images of 1746 cortical neurons, of which 852 neurons were reconstructed to quantify local dendritic morphology, and mapped to standard atlases. In our data, human neurons are more diverse across brain regions than by subject age or gender. The strong stereotypy within cohorts of brain regions allows generating a statistical tensor-field of neuron morphology to characterize anatomical modularity of a human brain.</p>
Human Embryonic Stem C ells-derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Mon-keys Recover Dopamine Levels and Motor Behavior
<p>Supplementary videos of the article "Human Embryonic Stem Cells-derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Mon-keys Recover Dopamine Levels and Motor Behavior"</p>
Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.
ClinicalTrials.gov study NCT02706314. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition
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Whole human-brain mapping of single cortical neurons for profiling morphological diversity and stereotypy
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Data from: Large and fast human pyramidal neurons associate with intelligence
It is generally assumed that human intelligence relies on efficient processing by neurons in our brain. Although gray matter thickness and activity of temporal and frontal cortical areas correlate with IQ scores, no direct evidence exists that links structural and physiological properties of neurons to human intelligence. Here, we find that high IQ scores and large temporal cortical thickness associate with larger, more complex dendrites of human pyramidal neurons. We show in silico that larger dendritic trees enable pyramidal neurons to track activity of synaptic inputs with higher temporal precision, due to fast action potential kinetics. Indeed, we find that human pyramidal neurons of individuals with higher IQ scores sustain fast action potential kinetics during repeated firing. These findings provide the first evidence that human intelligence is associated with neuronal complexity, action potential kinetics and efficient information transfer from input s to output within cortical neurons.
Data from: Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The ability to recapitulate age-related characteristics of human neurons in culture will offer unprecedented opportunities to study the biological processes underlying neuronal aging. Here, we show that using a recently demonstrated microRNA-based cellular reprogramming approach, human fibroblasts from postnatal to near centenarian donors can be efficiently converted into neurons that maintain multiple age-associated signatures. Application of an epigenetic biomarker of aging (referred to as epigenetic clock) to DNA methylation data revealed that the epigenetic ages of fibroblasts were highly correlated with corresponding age estimates of reprogrammed neurons. Transcriptome and microRNA profiles reveal genes differentially expressed between young and old neurons. Further analyses of oxidative stress, DNA damage and telomere length exhibit the retention of age-associated cellular properties in converted neurons from corresponding fibroblasts. Our results collectively demonstrate the maintenance of age after neuronal conversion.
Human brain with colorful neurons
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Human brain with colorful neurons
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Depletion of hypercapnia-responsive neurons in human cerebral- and brainstem-organoids of congenital central hypoventilation syndrome
<p>key Rdata for the paper.</p>
2D cortical human neuron from ipsc - cultures and electrical activiy based on HD-MEA
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Dataset related to article "Neonicotinoid pesticides affect developing neurons in experi-mental mouse models and in human induced pluripotent stem cell (iPSC)-derived neural cultures and organoids"
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Neonicotinoid pesticides affect developing neurons in experi-mental mouse models and in human induced pluripotent stem cell (iPSC)-derived neural cultures and organoids
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Zinc deficiency induces apoptosis via mitochondrial p53- and caspase-dependent pathways in human neuronal precursor cells
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Data from: Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains
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Data from: Large and fast human pyramidal neurons associate with intelligence
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ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.