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501 results for “Huntington's disease”
Data from: Structural and functional features of medium spiny neurons in the BACHDΔN17 mouse model of Huntington’s disease
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Clinical recommendations to guide physical therapy practice for Huntington disease
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Dietary ketosis improves circadian dysfunction as well as motor symptoms in the BACHD mouse model of Huntington’s disease
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Abnormal Development of Cerebellar-Striatal Circuitry in Huntington's Disease: Supplemental Figures
<p><b>Objective</b>: To test the hypothesis that the trajectory of functional connections over time of the striatum and the cerebellum differs between pre-symptomatic patients with the HD gene expansion (GE) and patients with a family history of HD but without the gene-expansion (GNE), we evaluated function MRI data from the Kids-HD study. </p> <p><b>Methods</b>: We utilized resting-state, functional MRI data from participants in the Kids-HD study between 6 to 18 years old. Participants were divided into the GE (CAG 36-59) and GNE (CAG <36) groups. Seed to seed correlations were calculated between four regions that provide input signals to the anterior cerebellum: 1) dorsocaudal putamen; 2) globus pallidus externa; 3) subthalamic nucleus, and 4) pontine nuclei and two regions that represented output from the cerebellum, the dentate nucleus to the: 1) ventrolateral thalamus and 2) dorsocaudal putamen. Linear mixed effects regression models evaluated differences in developmental trajectories of these connections over time between groups.</p> <p><b>Results</b>: Four of the six striatal-cerebellum correlations showed significantly different trajectories between groups. All showed a pattern where in the early age ranges (6-12 years), there was hyperconnectivity in the GE compared to the GNE with those trajectories showing linear decline in the latter half of the age range.</p> <p><b>Conclusion</b>: These results parallel previous findings showing striatal hypertrophy in GE children as early as age 6. These findings support the notion of developmentally higher connectivity between the striatum and cerebellum early in the life of the child with the HD gene expansion, possibly setting the stage for cerebellar compensatory mechanisms.</p>
Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease
ClinicalTrials.gov study NCT05707663. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Music Therapy on Huntington's Disease
ClinicalTrials.gov study NCT00178360. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)
ClinicalTrials.gov study NCT00712426. IPD Sharing: Not stated. Countries: 4. Publications: 9.
Study of Biomarkers That Predict the Evolution of Huntington's Disease
ClinicalTrials.gov study NCT01412125. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
ClinicalTrials.gov study NCT01574053. IPD Sharing: Not stated. Countries: 20. Publications: 3.
A Comparative Phase 2 Study Assessing the Efficacy of Triheptanoin, an Anaplerotic Therapy in Huntington's Disease
ClinicalTrials.gov study NCT02453061. IPD Sharing: Not stated. Countries: 2. Publications: 2.
TREND-HD - A Trial of Ethyl-EPA (Miraxion™) in Treating Mild to Moderate Huntington's Disease
ClinicalTrials.gov study NCT00146211. IPD Sharing: Not stated. Countries: 2. Publications: 1.
PHysical Activity and Exercise Outcomes in Huntington's Disease
ClinicalTrials.gov study NCT03344601. IPD Sharing: YES. Countries: 3. Publications: 3.
Safety Evaluation of Cellavita HD Administered Intravenously in Participants With Huntington's Disease
ClinicalTrials.gov study NCT02728115. IPD Sharing: UNDECIDED. Countries: 1. Publications: 8.
Exercise Effects in Huntington's Disease
ClinicalTrials.gov study NCT01879267. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Premanifest Huntington's Disease: Creatine Safety & Tolerability Extension Study
ClinicalTrials.gov study NCT01411150. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Neurobiological Predictors of Huntington's Disease (PREDICT-HD)
ClinicalTrials.gov study NCT00051324. IPD Sharing: YES. Countries: 1. Publications: 4.
Neuroprotection by Cannabinoids in Huntington's Disease
ClinicalTrials.gov study NCT01502046. IPD Sharing: Not stated. Countries: 1. Publications: 1.
GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
ClinicalTrials.gov study NCT05686551. IPD Sharing: YES. Countries: 15. Publications: 1.
Time-Restricted Eating in Huntington's Disease: A Clinical Pilot Study
ClinicalTrials.gov study NCT06490367. IPD Sharing: YES. Countries: 1. Publications: 2.
Nilotinib in Huntington's Disease
ClinicalTrials.gov study NCT03764215. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.