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111
datasets available to search
ShareScore release 0.9.0
Dataset results
111 results for “IMC”
Study of Effectiveness of IMC-A12 Antibody Combined With Hormone Therapy Prior to Surgery to Treat Prostate Cancer
ClinicalTrials.gov study NCT00769795. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Targeting Obesity With the Probiotic Lactiplantibacillus Plantarum IMC 510 (PRO-Weight-Control Study)
ClinicalTrials.gov study NCT05358301. IPD Sharing: NO. Countries: 1. Publications: 10.
Dose-escalation Study of IMC-001 in Subject With Metastatic or Locally-advanced Solid Tumors
ClinicalTrials.gov study NCT03644056. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of IMC-11F8 in Patients With Tumors Who Have Not Responded to Standard Therapy
ClinicalTrials.gov study NCT00801177. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Multicenter Study Using IMC to Analyze the Impact of ICANS on Microglia
ClinicalTrials.gov study NCT05811117. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of IMC-1121B in Patients With Advanced Solid Tumors Not Responding To Standard Therapy
ClinicalTrials.gov study NCT00786383. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of IMC-A12 Every 2 Weeks in Patients With Tumors Who No Longer Respond to Treatment or No Treatment is Available
ClinicalTrials.gov study NCT00785941. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of IMC-002 in Patients With Advanced Cancer Failed to Standard Therapy
ClinicalTrials.gov study NCT05276310. IPD Sharing: NO. Countries: 1. Publications: 0.
The spatial landscape of lung pathology during COVID-19 progression - processed IMC data
<p>Recent studies have provided insights into the pathology and immune response to coronavirus disease 2019 (COVID-19). However thorough interrogation of the interplay between infected cells and the immune system at sites of infection is lacking. We use high parameter imaging mass cytometry9 targeting the expression of 36 proteins, to investigate at single cell resolution, the cellular composition and spatial architecture of human acute lung injury including SARS-CoV-2. This spatially resolved, single-cell data unravels the disordered structure of the infected and injured lung alongside the distribution of extensive immune infiltration. Neutrophil and macrophage infiltration are hallmarks of bacterial pneumonia and COVID-19, respectively. We provide evidence that SARS-CoV-2 infects predominantly alveolar epithelial cells and induces a localized hyper-inflammatory cell state associated with lung damage. By leveraging the temporal range of COVID-19 severe fatal disease in relation to the time of symptom onset, we observe increased macrophage extravasation, mesenchymal cells, and fibroblasts abundance concomitant with increased proximity between these cell types as the disease progresses, possibly as an attempt to repair the damaged lung tissue. This spatially resolved single-cell data allowed us to develop a biologically interpretable landscape of lung pathology from a structural, immunological and clinical standpoint. This spatial single-cell landscape enabled the pathophysiological characterization of the human lung from its macroscopic presentation to the single-cell, providing an important basis for the understanding of COVID-19, and lung pathology in general.</p>
OMAP-8: Multiplexed Antibody-Based Imaging of Placenta with Imaging Mass Cytometry (IMC), v1.0
<p>OMAP-8 was designed for Imaging Mass Cytometry (IMC) (<a href="https://pubmed.ncbi.nlm.nih.gov/24584193/">https://pubmed.ncbi.nlm.nih.gov/24584193/</a>) of formalin-fixed paraffin-embedded (FFPE) human term-placenta samples. The tissue slides were prepared with a two-step antigen retrieval process (pH 6 and pH 9, as described <a href="https://dx.doi.org/10.17504/protocols.io.bpwumpew">https://dx.doi.org/10.17504/protocols.io.bpwumpew</a>). OMAP antibodies validated by immunohistochemistry and IMC were conjugated to polymers containing metal isotopes. Conjugated antibodies were used to stain processed human term-placenta tissue simultaneously. Regions of the processed tissue were then acquired on the imaging mass cytometer (Hyperion; Standard BioTools) by laser ablation and visualized. The panel contains 26 antibodies conjugated to unique metal isotopes and iridium marks the DNA. This OMAP provides a spatial context for key placenta cell types in the <a href="https://doi.org/10.48539/HBM446.WGLG.755">ASCT+B v.1.0 table</a>. Single-cell RNA sequencing data were used to guide marker selection for multiplexed tissue imaging. For example, ASCL2, HLA-G, PD-L1, CD68 and LYVE1 allow functionally specialized cell types to be visualized and quantified in the placenta. Note that one of our core antibodies is to LYVE1 but, unlike in other tissues where it is used to mark lymphatic vasculature, here we use it to mark the macrophage of the placenta (Hofbauer cells) – there should be no lymphatics in the placenta.</p>
Study of IMC-11F8 in Participants With Advanced Solid Tumors
ClinicalTrials.gov study NCT01088464. IPD Sharing: YES. Countries: 1. Publications: 0.
IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by Surgery
ClinicalTrials.gov study NCT00778817. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Virtual Reality on the IMC
ClinicalTrials.gov study NCT05380700. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study for Safety and Effectiveness of IMC-A12 by Itself or Combined With Antiestrogens to Treat Breast Cancer
ClinicalTrials.gov study NCT00728949. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of IMC-RON8 in Advanced Solid Tumors
ClinicalTrials.gov study NCT01119456. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study Using IMC-A12 (Cixutumumab) With or Without Cetuximab in Participants With Metastatic Colorectal Cancer Who Have Failed a Treatment Regimen That Consisted of a Prior Anti-EGFR Therapy
ClinicalTrials.gov study NCT00503685. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of Ramucirumab (IMC-1121B) in Combination With Eribulin Versus Eribulin Alone in Participants With Breast Cancer
ClinicalTrials.gov study NCT01427933. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of Ramucirumab (IMC-1121B) in Participants With Breast Cancer
ClinicalTrials.gov study NCT01256567. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of IMC-A12, Alone or in Combination With Cetuximab, in Participants With Recurrent or Metastatic Squamous Cell Carcinoma (MSCC) of the Head and Neck
ClinicalTrials.gov study NCT00617734. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of Irinotecan and Cetuximab With or Without IMC-A12 for Treatment of Participants With Colon or Rectum Cancer Who Got Worse After Their First Treatment With Oxaliplatin and Bevacizumab
ClinicalTrials.gov study NCT00845039. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.