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ShareScore release 0.9.0
Dataset results
453 results for “Idiopathic pulmonary fibrosis”
A Study to Characterize the Disease Behavior of Idiopathic Pulmonary Fibrosis (IPF) and Interstitial Lung Disease (ILD) During the Peri-Diagnostic Period
ClinicalTrials.gov study NCT03261037. IPD Sharing: UNDECIDED. Countries: 6. Publications: 2.
Safety, Tolerability, and Pharmacokinetic Study of TRK-250 for Patients With Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT03727802. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Three-Arm Study of the Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT00287716. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Sildenafil Trial of Exercise Performance in Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT00517933. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Clinical Study to Test How Effective and Safe GLPG1690 is for Subjects With Idiopathic Pulmonary Fibrosis (IPF) When Used Together With Standard of Care
ClinicalTrials.gov study NCT03711162. IPD Sharing: NO. Countries: 15. Publications: 3.
A Clinical Study to Test How Effective and Safe GLPG1205 is for Participants With Idiopathic Pulmonary Fibrosis (IPF)
ClinicalTrials.gov study NCT03725852. IPD Sharing: NO. Countries: 9. Publications: 1.
A Study to Evaluate Long Term Safety and Efficacy of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT04594707. IPD Sharing: YES. Countries: 28. Publications: 1.
A Phase 2, Randomized Dose-ranging Study to Evaluate the Efficacy of Tralokinumab in Adults With Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT01629667. IPD Sharing: Not stated. Countries: 6. Publications: 1.
A Study to Evaluate the Efficacy and Safety of CC-90001 in Subjects With Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT03142191. IPD Sharing: Not stated. Countries: 13. Publications: 3.
Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT00287729. IPD Sharing: Not stated. Countries: 1. Publications: 14.
A Pilot Trial of Herpesvirus Treatment in Idiopathic Pulmonary Fibrosis (IPF)
ClinicalTrials.gov study NCT02871401. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety And Efficacy of BIBF 1120 in Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT00514683. IPD Sharing: Not stated. Countries: 25. Publications: 4.
Roll Over Study From 1199.30 BIBF 1120 in Idiopathic Pulmonary Fibrosis (IPF)
ClinicalTrials.gov study NCT01170065. IPD Sharing: Not stated. Countries: 21. Publications: 1.
The lower airways microbiome and antimicrobial peptides in Idiopathic Pulmonary Fibrosis differ from Chronic Obstructive Pulmonary Disease
<p><strong>Background</strong>: The lower airways microbiome and host immune response in chronic pulmonary diseases are incompletely understood. We aimed to investigate possible microbiome characteristics and key antimicrobial peptides and proteins in idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).</p> <p><strong>Methods</strong>: 12 IPF patients, 12 COPD patients and 12 healthy controls were sampled with oral wash (OW), protected bronchoalveolar lavage (PBAL) and right lung protected sterile brushings (rPSB). The antimicrobial peptides and proteins (AMPs), secretory leucocyte protease inhibitor (SLPI) and human beta defensins 1 and 2 (hBD-1 & hBD-2), were measured in PBAL by enzyme linked immunosorbent assay (ELISA).</p> <p>The V3V4 region of the bacterial 16S rDNA gene was sequenced. Bioinformatic analyses were performed with QIIME 2.</p> <p><strong>Results</strong>: hBD-1 levels in PBAL for IPF were lower compared with COPD. The predominant phylae in IPF were <i>Firmicutes</i>, <i>Bacteroides</i> and <i>Actinobacteria</i>; <i>Proteobacteria</i> were among top three in COPD. Differential abundance analysis at genus level showed significant differences between study groups for less abundant, mostly oropharyngeal, microbes. Alpha diversity was lower in IPF in PBAL compared to COPD (p=0.03) and controls (p=0.01), as well as in rPSB compared to COPD (p=0.02) and controls (p=0.04). Phylogenetic beta diversity showed significantly more similarity for IPF compared with COPD and controls. There were no significant correlations between alpha diversity and AMPs.</p> <p><strong>Conclusions</strong>: IPF differed in microbial diversity from COPD and controls, accompanied by differences in antimicrobial peptides. Beta diversity similarity between OW and PBAL in IPF may indicate that microaspiration contributes to changes in its microbiome<b>.</b></p>
Patients' experiences of coping with Idiopathic Pulmonary Fibrosis (IPF) and their recommendations for its clinical management
<p>Transcripts of patient interviews.</p>
Impact of a Systematic Palliative Care on Quality of Life, in Advanced Idiopathic Pulmonary Fibrosis.
ClinicalTrials.gov study NCT03229343. IPD Sharing: NO. Countries: 1. Publications: 3.
Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT06567717. IPD Sharing: NO. Countries: 1. Publications: 4.
Microarray Analysis of Gene Expression in Idiopathic Pulmonary Fibrosis (IPF)
ClinicalTrials.gov study NCT00258544. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Idiopathic Pulmonary Fibrosis (IPF) and the 3 Minutes Sit-to-stand Test
ClinicalTrials.gov study NCT03268915. IPD Sharing: UNDECIDED. Countries: 1. Publications: 19.
Study of GC1008 in Patients With Idiopathic Pulmonary Fibrosis (IPF)
ClinicalTrials.gov study NCT00125385. IPD Sharing: Not stated. Countries: 2. Publications: 1.
ScienceDex guides
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OpenNeuro
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