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129 results for “LEM”
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
ClinicalTrials.gov study NCT00064792. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome
ClinicalTrials.gov study NCT00272844. IPD Sharing: Not stated. Countries: 1. Publications: 5.
7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome
Open the record for dataset details and reuse information.
Data from: Demographic responses of a site-faithful and territorial predator to its fluctuating prey: long-tailed skuas and arctic lemmings
1. Environmental variability, through interannual variation in food availability or climatic variables, is usually detrimental to population growth. It can even select for constancy in key life-history traits, though some exceptions are known. Changes in the level of environmental variability are therefore important to predict population growth or life-history evolution. Recently, several cyclic vole and lemming populations have shown large dynamical changes, that might affect rodent predator demography or life histories. 2. Skuas constitute an important case study among rodent predators, because of their strongly saturating breeding productivity (they lay only two eggs) and high degree of site fidelity, in which they differ from nomadic predators raising large broods in good rodent years. This suggests that they cannot capitalize on lemming peaks to the same extent as nomadic predators, and might be more vulnerable to collapses of rodent cycles. 3. We develop a model for the population dynamics of long-tailed skuas feeding on lemmings to assess the demographic consequences of such variable and nonstationary prey dynamics, based on data collected in NE Greenland. The model shows that populations of long-tailed skua sustain well changes in lemming dynamics, including temporary collapses (e.g. 10 years). A high floater-to-breeder ratio emerges from rigid territorial behaviour and a long life expectancy, which buffers the impact of adult abundance's decrease on the population reproductive output. 4. The size of the floater compartment is affected by changes in both mean and coefficient of variation of lemming densities (but not cycle amplitude and periodicity per se). In Greenland, the average lemming density is below the threshold density required for successful breeding (including during normally cyclic periods). Due to Jensen's inequality, skuas therefore benefit from lemming variability; a positive effect of environmental variation. 5. Long-tailed skua populations are strongly adapted to fluctuating lemming populations, an instance of demographic lability in the reproduction rate. They are also little affected by poor lemming periods, if there are enough floaters, or juveniles disperse to neighbouring populations. The status of Greenland skua populations therefore strongly depends upon floater numbers and juvenile movements, which are not known. This reveals a need to intensify colour-ringing efforts on the long-tailed skua at a circumpolar scale.
Data from: Seasonal difference in temporal transferability of an ecological model: near-term predictions of lemming outbreak abundances
Ecological models have been criticized for a lack of validation of their temporal transferability. Here we answer this call by investigating the temporal transferability of a dynamic state-space model developed to estimate season-dependent biotic and climatic predictors of spatial variability in outbreak abundance of the Norwegian lemming. Modelled summer and winter dynamics parametrized by spatial trapping data from one cyclic outbreak were validated with data from a subsequent outbreak. There was a distinct difference in model transferability between seasons. Summer dynamics had good temporal transferability, displaying ecological models' potential to be temporally transferable. However, the winter dynamics transferred poorly. This discrepancy is likely due to a temporal inconsistency in the ability of the climate predictor (i.e. elevation) to reflect the winter conditions affecting lemmings both directly and indirectly. We conclude that there is an urgent need for data and models that yield better predictions of winter processes, in particular in face of the expected rapid climate change in the Arctic.
Data from: Run to the hills: gene flow among mountain areas leads to low genetic differentiation in the Norwegian lemming
The endemic Norwegian lemming (Lemmus lemmus) is an icon for cyclic species, famous since the Middle Ages for its enormous population outbreaks and mass movements. Although the drivers behind this cyclicity have been intensively investigated, virtually nothing is known about the extent to which long-distance dispersal during population peaks actually lead to gene flow among mountain tundra areas. In this article, we use nine microsatellite markers to address this question and analyse range-wide genetic diversity and differentiation between Fennoscandian sub-regions. The results revealed a high genetic variation with a surprisingly weak population structure, comparable to that of much larger mammals. The differentiation was mainly characterized as a genetic cline across the species' entire distribution, and results from spatial autocorrelation analyses suggested that gene flow occurs with sufficiently high frequency to create a genetic patch size of 100 km. Further, we found that for the equivalent distances, the southern sub-regions were genetically more similar to each other than those in the north, which indicates that the prolonged periods of interrupted lemming cyclicity recorded in the northern parts of Fennoscandia have led to increased isolation and population differentiation. In summary, we propose that mass movements during peak years act as pulses of gene flow between mountain tundra areas, and that these help to maintain genetic variation and counteract differentiation over vast geographic distances.
1 lemming
Source: Objaverse 1.0 / Sketchfab
FIGURE 13 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 13. Bayesian phylogeny for Arostrilepis spp. based on cytochrome b. Circles on branches indicate nodes with Bayesian posterior probabilities of 0.95 or greater. Numbers inside circles or on branches indicate maximum likelihood bootstrap values greater than 60. Four letter host identification codes in parentheses following Arostrilepis species names indicate all primary hosts from which each parasite species has been reported. Underlined host codes denote hosts from which parasites were sampled to build this phylogeny. Host identifications are as follows: Aram—Arvicola amphibius, Arsc—A. scherman, Chni - Chionomys nivalis, Lesi - Lemmus sibiricus, Letr—L. trimucronatus, Mysc - Myopus schisticolor, Sybo—Synaptomys borealis, Miag - Microtus agrestis, Miar—M. arvalis, Milo—M. longicaudus, Mima—M. maximowiczii, Mimi—M. miurus, Mimu—M. multiplex, Mioe—M. oeconomus, Mipe—M. pennsylvanicus, Mixa—M. xanthognathus, Myga —Myodes gapperi, Mygl—M. glareolus, Myre—M. rex, Myrf—M. rufocanus, Myrt—M. rutilus.
FIGURE 8 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 8. Arostrilepis beringiensis (Kontrimavichus & Smirnova, 1991) based on voucher specimens from the Nearctic. A. Dorsoventral view of scolex (MSB 1234); B. Cirrus (MSB 1233); C. Hermaphroditic mature proglottis (MSB 1234); D. Egg (MSB 1228). Scale bars: A = 200 µm; B, D = 20 µm; C = 500 µm.
FIGURE 7 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 7. Arostrilepis rauschorum sp. n. A. Paratype (MSB 1363), cirrus; B. Egg (MSB 1216); C. Holotype, distal part of the vagina (MSB 1208); D. Holotype, gravid proglottis. Scale bars: A, B = 20 µm; C = 100 µm; D = 500 µm.
FIGURE 5 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 5. Arostrilepis cooki sp. n. A. Paratype (MSB 1250), cirrus; B. Holotype, egg; C. Holotype, distal part of the vagina; D. Holotype, gravid proglottis. Scale bars: A, B = 20 µm; C = 100 µm; D = 500 µm.
FIGURE 4 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 4. Arostrilepis cooki sp. n. A. Paratype (MSB 1245), dorsoventral view of scolex; B. Paratype (MSB 1217), dorsoventral view of scolex; C. Holotype, male mature proglottides (MSB 1244); D. Holotype, hermaphroditic mature proglottides. Scale bars: A, B = 200 µm; C, D = 500 µm.
FIGURE 2 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 2. Arostrilepis gulyaevi sp. n. A. Holotype, dorsoventral view of scolex (ISEA 18.28.8.1); B. Paratype, sublateral view of scolex (MSB 1261); C. Holotype, male mature proglottides; D. Holotype, hermaphroditic mature proglottides. Scale bars: A, B = 200 µm; C, D = 500 µm.
FIGURE 10 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 10. Arostrilepis cf. janickii Makarikov & Kontrimavichus, 2011 based on voucher specimen from the Nearctic. A. Dorsoventral view of scolex (MSB 1268); B. Cirrus (MSB 1268); C. Hermaphroditic mature proglottis (MSB 1268). Scale bars: A = 200 µm; B = 20 µm; C = 500 µm.
FIGURE 9 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 9. Arostrilepis macrocirrosa Makarikov, Gulyaev & Kontrimavichus, 2011 based on voucher specimen from the Nearctic. A. Dorsoventral view of scolex (MSB 1285); B. Cirrus (MSB 1302); C. Hermaphroditic mature proglottis (MSB 1306); D. Egg (MSB 1306). Scale bars: A = 200 µm; B, D = 20 µm; C = 500 µm.
FIGURE 6 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 6. Arostrilepis rauschorum sp. n. A. Paratype (MSB 1371), dorsoventral view of scolex; B. Paratype (MSB 1370), sublateral view of scolex; C. Holotype, male mature proglottides (MSB 1208); D. Holotype, hermaphroditic mature proglottis. Scale bars: A, B = 200 µm; C, D = 500 µm.
FIGURE 3 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 3. Arostrilepis gulyaevi sp. n. A. Paratype, cirrus (ISEA 18.28.8.8); B. Paratype, egg (MSB 1254); C - holotype, distal part of the vagina (ISEA 18.28.8.1); D. Holotype, posmature proglottis, showing uterus development; E. Holotype, gravid proglottis. Scale bars: A, B = 20 µm; C = 100 µm; D, E = 500 µm.
FIGURE 12 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 12. Cirrus structure among species of Arostrilepis including newly designated and Holarctic taxa. A. A. rauschorum sp. n.; B. A. gulyaevi sp. n.; C. A. cooki sp. n.; D. A. beringiensis; E. A. c.f. janickii; F. A. macrocirrosa. Scale bar: 20 µm.
FIGURE 11 in Parasite diversity at the Holarctic nexus: species of Arostrilepis (Eucestoda: Hymenolepididae) in voles and lemmings (Cricetidae: Arvicolinae) from greater Beringia
FIGURE 11. Cirrus structure among species of Arostrilepis. A. A. horrida; B. A. beringiensis; C. A. microtis (paratype ISEA 756); D. A. tenuicirrosa; E. A. macrocirrosa; F. A. janickii; G. A. intermedia; H. A. schilleri; I. A. mariettavogeae. Scale bar: 20 µm. (A,D,E after Makarikov et al. 2011; B,F,G after Makarikov & Kontrimavichus 2011; H,I after Makarikov et al. 2012).
On following pages: 79. Eastern Mole Vole (Ellobius tancrei); 80. Alai Mole Vole (Ellobius alaicus); 81. Southern Mole Vole (Ellobius fuscocapillus); 82. Transcaucasian Mole Vole (Ellobius lutescens); 83. Yellow Steppe Lemming (Eolagurus luteus); 84. Przewalski's Steppe Lemming (Eolagurus przewalskii); 85. Steppe Vole (Lagurus lagurus), 86. South-western Water Vole (Arvicola sapidus); 87. Eurasian Water Vole (Arvicola amphibius); 88. Montane Water Vole (Arvicola monticola); 89. Italian Water Vole (Arvicola italicus); 90. Sagebrush Vole (Lemmiscus curtatus); 91. European Snow Vole (Chionomys nivalis); 92. Robert's Snow Vole (Chionomys robert); 93. Gudaur Snow Vole (Chionomys gud); 94. Lazistan Snow Vole (Chionomys lasistanius); 95. Sichuan Vole (Volemys millicens); 96. Marie's Vole (Volemys musseri); 97. Duke of Bedford's Vole (Proedromys bedford); 98. Liangshan Vole (Proedromys liangshanensis); 99. Brandt's Vole (Lasiopodomys brandftil); 100. Mandarin Vole (Lasiopodomys mandarinus); 101. Narrow-headed Vole (Lasiopodomys gregalis); 102. Radde's Vole (Lasiopodomys raddei); 103. Sikkim Mountain Vole (Neodon sikimensis); 104. Linzhi Mountain Vole (Neodon linzhiensis); 105. Clarke's Vole (Neodon clarke); 106. Medog Mountain Vole (Neodon medogensis); 107. Nyalam Mountain Vole (Neodon nyalamensis); 108. Irene Mountain Vole (Neodon irene); 109. Forrest's Mountain Vole (Neodon forresti); 110. Blyth's Mountain Vole (Neodon leucurus); 111. Smoky Mountain Vole (Neodon fuscus). in Cricetidae
On following pages: 79. Eastern Mole Vole (Ellobius tancrei); 80. Alai Mole Vole (Ellobius alaicus); 81. Southern Mole Vole (Ellobius fuscocapillus); 82. Transcaucasian Mole Vole (Ellobius lutescens); 83. Yellow Steppe Lemming (Eolagurus luteus); 84. Przewalski's Steppe Lemming (Eolagurus przewalskii); 85. Steppe Vole (Lagurus lagurus), 86. South-western Water Vole (Arvicola sapidus); 87. Eurasian Water Vole (Arvicola amphibius); 88. Montane Water Vole (Arvicola monticola); 89. Italian Water Vole (Arvicola italicus); 90. Sagebrush Vole (Lemmiscus curtatus); 91. European Snow Vole (Chionomys nivalis); 92. Robert's Snow Vole (Chionomys robert); 93. Gudaur Snow Vole (Chionomys gud); 94. Lazistan Snow Vole (Chionomys lasistanius); 95. Sichuan Vole (Volemys millicens); 96. Marie's Vole (Volemys musseri); 97. Duke of Bedford's Vole (Proedromys bedford); 98. Liangshan Vole (Proedromys liangshanensis); 99. Brandt's Vole (Lasiopodomys brandftil); 100. Mandarin Vole (Lasiopodomys mandarinus); 101. Narrow-headed Vole (Lasiopodomys gregalis); 102. Radde's Vole (Lasiopodomys raddei); 103. Sikkim Mountain Vole (Neodon sikimensis); 104. Linzhi Mountain Vole (Neodon linzhiensis); 105. Clarke's Vole (Neodon clarke); 106. Medog Mountain Vole (Neodon medogensis); 107. Nyalam Mountain Vole (Neodon nyalamensis); 108. Irene Mountain Vole (Neodon irene); 109. Forrest's Mountain Vole (Neodon forresti); 110. Blyth's Mountain Vole (Neodon leucurus); 111. Smoky Mountain Vole (Neodon fuscus).
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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