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182
datasets available to search
ShareScore release 0.9.0
Dataset results
182 results for “Leishmania”
Asymptomatic Leishmania Infection in HIV Patients
ClinicalTrials.gov study NCT02839603. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of a New Leishmania Vaccine Candidate ChAd63-KH
ClinicalTrials.gov study NCT02894008. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Study to Assess the Safety, Efficacy and Immunogenicity of Leishmania Vaccine ChAd63-KH in PKDL
ClinicalTrials.gov study NCT03969134. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Leishmania naiffi and Leishmania guyanensis reference genomes highlight genome structure and gene evolution in the Viannia subgenus
The unicellular protozoan parasite Leishmania causes the neglected tropical disease leishmaniasis, affecting 12 million people in 98 countries. In South America where the Viannia subgenus predominates, so far only L. (Viannia) braziliensis and L. (V.) panamensis have been sequenced, assembled and annotated as reference genomes. Addressing this deficit in molecular information can inform species typing, epidemiological monitoring and clinical treatment. Here, L. (V.) naiffi and L. (V.) guyanensis genomic DNA was sequenced to assemble these two genomes as draft references from short sequence reads. The methods used were tested using short sequence reads for L. braziliensis M2904 against its published reference as a comparison. This assembly and annotation pipeline identified 70 additional genes not annotated on the original M2904 reference. Phylogenetic and evolutionary comparisons of L. guyanensis and L. naiffi with ten other Viannia genomes revealed four traits common to all Viannia: aneuploidy, 22 orthologous groups of genes absent in other Leishmania subgenera, elevated TATE transposon copies, and a high NADH-dependent fumarate reductase gene copy number. Within the Viannia, there were limited structural changes in genome architecture specific to individual species: a 45 Kb amplification on chromosome 34 was present in all bar L. lainsoni, L. naiffi had a higher copy number of the virulence factor leishmanolysin, and laboratory isolate L. shawi M8408 had a possible minichromosome derived from the 3' end of chromosome 34. This combination of genome assembly, phylogenetics and comparative analysis across an extended panel of diverse Viannia has uncovered new insights into the origin and evolution of this subgenus and can help improve diagnostics for leishmaniasis surveillance.
First report of cutaneous leishmaniasis caused by Leishmania donovani in Ethiopia
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Figure 1 in Ecological aspects and molecular detection of Leishmania DNA (Kinetoplastida: Trypanosomatidae) in phlebotomine sand flies (Diptera: Psychodidae) from a rural settlement in the Eastern Amazon, Brazil
Figure 1 Map of the study area and sand flies collection points, Perimetral Norte Rural Seattlement, Pedra Branca Municipality, Amapá State, Brazil.
Fig. 3 in Utilising a novel surveillance system to investigate species of Forcipomyia (Lasiohelea) (Diptera: Ceratopogonidae) as the suspected vectors of Leishmania macropodum (Kinetoplastida: Trypanosomatidae) in the Darwin region of Australia
Fig. 3. Evaluation of L. macropodum viability on FTAṜ cards and the effect of honey. To determine L. macropodum detection on honeycoated and plain FTAṜ cards, an experiment was designed over a 10-week time course. FTAṜ cards (2.5 × 2.5 cm) were inoculated with 10 6 L. macropodum per card in triplicates and DNA was tested at five time points (week 0, 2, 5, 8 and 10).
Safety, False-Positive Reactions and Sensitizing Properties of Leishmania Tropica Skin Test Antigen
ClinicalTrials.gov study NCT00633009. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With no Response to Leishmanin
ClinicalTrials.gov study NCT00429715. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Leishmania naiffi and Leishmania guyanensis reference genomes highlight genome structure and gene evolution in the Viannia subgenus
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Data from: Proteomic analysis reveals a predominant NFE2L2 (NRF2) signature in the canonical pathway and upstream regulator analysis of Leishmania-infected macrophages
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Differential gene expression analysis between Miltefosine resistant and sensitive leishmania donovani
GEO Series GSE30685. Leishmania donovani; Leishmania. 6 samples. Type: Expression profiling by array.
Whole genome microarray analysis of mouse liver subjected to Leishmania donovani infection
GEO Series GSE38985. Mus musculus. 5 samples. Type: Expression profiling by array.
Transcriptionally Driven DNA Replication Programme of the Human Parasite Leishmania major
GEO Series GSE81991. Leishmania major strain Friedlin. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
GENE EXPRESSION PROFILING AND MOLECULAR CHARACTERIZATION OF ANTIMONY RESISTANCE IN Leishmania amazonensis
GEO Series GSE26159. Leishmania; Leishmania amazonensis. 5 samples. Type: Expression profiling by array.
Expression data from Leishmania major infected human dendritic cells
GEO Series GSE42088. Homo sapiens. 15 samples. Type: Expression profiling by array.
The Role of Leishmania GP63 in Modulation of Innate Inflammatory Response to Leishmania major Infection
GEO Series GSE189385. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Interspecies hybridization versus intra-species hybridization for Leishmania promastigote RNA.
GEO Series GSE4430. Leishmania mexicana; Leishmania major. 4 samples. Type: Expression profiling by array.
Differential gene expression in DEVH1 knock-in Leishmania infantum promastigotes
GEO Series GSE202674. Leishmania infantum. 1 samples. Type: Expression profiling by array.
Transcriptome analyses of Leishmania donovani promastigotes depleted of SET7 and SET29 proteins, under normal and oxidative growth environment [exp 2]
GEO Series GSE267957. Leishmania donovani. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.