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95 results for “Local staging”
Chemotherapy Combination With Local Radiotherapy and rhGM-CSF for Oligometastatic Stage IV NSCLC Patients
ClinicalTrials.gov study NCT03489616. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Data from: High genetic variation in resting stage production in a metapopulation: is there evidence for local adaptation?
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Data from: The role of local ecology during hybridisation at the initial stages of ecological speciation in a marine snail
Hybrid zones of ecologically divergent populations are ideal systems to study the interaction between natural selection and gene flow during the initial stages of speciation. Here we perform an AFLP genome scan in parallel hybrid zones between divergent ecotypes of the marine snail Littorina saxatilis, which is considered a model case for the study of ecological speciation. RB (Ridged-Banded) and SU (Smooth-Unbanded) ecotypes are adapted to different shore levels and microhabitats, although they present a sympatric distribution at the mid-shore where they meet and mate (partially assortatively). We used shell morphology, outlier and non-outlier AFLP loci from RB, SU and hybrid specimens captured in sympatry to determine the level of phenotypic and genetic introgression. We found different levels of introgression at parallel hybrid zones and non-outlier loci showed more gene flow with greater phenotypic introgression. These results were independent from the phylogeography of the studied populations, but not from the local ecological conditions. Genetic variation at outlier loci was highly correlated with phenotypic variation. In addition, we used the relationship between genetic and phenotypic variation to estimate the heritability of morphological traits and to identify potential QTLs to be confirmed in future crosses. These results suggest that ecology (exogenous selection) plays an important role in this hybrid zone. Thus, ecologically-based divergent natural selection is responsible, simultaneously, for both ecotype divergence and hybridisation. On the other hand, genetic introgression occurs only at neutral loci (non-outliers). In the future, genome-wide studies and controlled crosses would give more valuable information about this process of speciation in the face of gene flow.
Study of the PD-L1 Inhibitor Atezolizumab With or Without Low-dose, Local Radiation in Patients With Relapsed or Refractory Advanced Stage Follicular Lymphoma
ClinicalTrials.gov study NCT03465891. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of Tislelizumab (BGB-A317) Plus Chemoradiotherapy Followed by Tislelizumab Monotherapy in Newly Diagnosed, Stage III Subjects With Locally Advanced, Unresectable Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT03745222. IPD Sharing: Not stated. Countries: 23. Publications: 0.
Study Of Zelboraf (Vemurafenib) in Patients With Locally-Advanced, Unresectable, Stage IIIc Or Metastatic Melanoma and Activating Exon 15 BRAF Mutations Other Than V600E
ClinicalTrials.gov study NCT01586195. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Added Value of DBT Over Mammography in Local Tumor Staging in Patients With BIRADS 4 or 5 Lesions
ClinicalTrials.gov study NCT06854887. IPD Sharing: Not stated. Countries: 0. Publications: 3.
A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)
ClinicalTrials.gov study NCT04513925. IPD Sharing: YES. Countries: 26. Publications: 0.
Data from: The genomic landscape at a late stage of stickleback speciation: high genomic divergence interspersed by small localized regions of introgression
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Data from: The role of local ecology during hybridisation at the initial stages of ecological speciation in a marine snail
Open the record for dataset details and reuse information.
Gene expression divergence between locally adapted inland annual and coastal perennial ecotypes of Mimulus guttatus across developmental stages
GEO Series GSE280929. Erythranthe guttata. 80 samples. Type: Expression profiling by high throughput sequencing.
A Trial of SHR-A1811 Compared to Other Antitumor Therapies as Neoadjuvant Treatments in Early-stage or Locally Advanced HER2-positive Breast Cancer
ClinicalTrials.gov study NCT07196774. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Organ Preservation in the Multispeciality Therapy of Stage II-IV Locally Advanced Head and Neck Cancer
ClinicalTrials.gov study NCT01187472. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase I/II Trial of Doxil and Hyperthermia for Breast Cancer Patients With Chest Wall Recurrence or Stage IV Disease With Locally Advanced Breast Cancer
ClinicalTrials.gov study NCT00006433. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC)
ClinicalTrials.gov study NCT05170204. IPD Sharing: YES. Countries: 19. Publications: 0.
Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in the Treatment of Stage II Periodontitis
ClinicalTrials.gov study NCT05241509. IPD Sharing: YES. Countries: 1. Publications: 0.
Combination Chemotherapy in Treating Patients With Stage IV Locally Advanced or Metastatic Bladder Cancer
ClinicalTrials.gov study NCT00005086. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pembrolizumab Combined With Preoperative Chemotherapy (Albumin Paclitaxel+Carboplatin) Neoadjuvant Therapy for Resectable Locally Advanced (Stage II/III) Esophageal Squamous Cell Carcinoma
ClinicalTrials.gov study NCT06304350. IPD Sharing: NO. Countries: 1. Publications: 0.
Gut and Tumor Microbiome in Patients With Early Stage (II-III), Locally Advanced or Advanced ER-positive and HER2-negative Breast Cancer.
ClinicalTrials.gov study NCT06126003. IPD Sharing: NO. Countries: 1. Publications: 0.
Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for Patients With Advanced Stage HCC, Unresectable & Not Eligible for Local Ablation and/or TACE
ClinicalTrials.gov study NCT01539018. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.