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63
datasets available to search
ShareScore release 0.9.0
Dataset results
63 results for “MHC genes”
Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_DAC]
GEO Series GSE53466. Mus musculus. 6 samples. Type: Expression profiling by array.
A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons
GEO Series GSE54061. Mus musculus. 24 samples. Type: Other.
Multi-omics analysis identifies erythroid cells as the major population in mouse placentas expressing the MHC class II antigen presentation, chemokine, and antibacterial immune response genes [Spatial
GEO Series GSE289170. Mus musculus. 6 samples. Type: Other.
ZBTB32 Is an Early Repressor of the CIITA MHC Class II Gene Expression during B Cell Differentiation to Plasma Cells
GEO Series GSE17999. Mus musculus. 4 samples. Type: Expression profiling by array.
Transcriptome analysis of Brucella abortus S19∆per (a perosaminesynthetase gene mutant of strain S19) immunized mice spleen revealed activation of MHC-I and MHC-II pathways
GEO Series GSE121040. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Data from: Contrasting evolutionary histories of MHC class I and class II loci in grouse - effects of selection and gene conversion
Genes of the major histocompatibility complex (MHC) encode receptor molecules that are responsible for recognition of intra- and extra-cellular pathogens (class I and class II genes, respectively) in vertebrates. Given the different roles of class I and II MHC genes, one might expect the strength of selection to differ between these two classes. Different selective pressures may also promote different rates of gene conversion at each class. Despite these predictions, surprisingly few studies have looked at differences between class I and II genes in terms of both selection and gene conversion. Here, we investigated the molecular evolution of MHC class I and II genes in five closely related species of prairie grouse (Centrocercus and Tympanuchus) that possess one class I and two class II loci. We found striking differences in the strength of balancing selection acting on MHC class I versus class II genes. More than half of the putative antigen-binding sites (ABS) of class II were under positive or episodic diversifying selection, compared with only 10% at class I. We also found that gene conversion played a stronger role in shaping the evolution of MHC class II than class I. Overall, the combination of strong positive (balancing) selection and frequent gene conversion has maintained higher diversity of MHC class II than class I in prairie grouse. This is one of the first studies clearly demonstrating that macroevolutionary mechanisms can act differently on genes involved in the immune response against intra- and extra-cellular pathogens.
Gene expression analysis in mice with heart muscle-specific repression of CELF activity (MHC-CELFdelta)
GEO Series GSE40677. Mus musculus. 12 samples. Type: Expression profiling by array.
Data from: Contrasting evolutionary histories of MHC class I and class II loci in grouse - effects of selection and gene conversion
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Gene expresion profile of different clusters of antigen specific CD4+ T cells induced by vaccines containing high doses of MHC-II restricted neoantigens
GEO Series GSE268300. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Cannabinoids act as H3k27ac Epigenetic Modifiers of Genes Regulating MHC-I Antigen Processing and Presentation that Induce Cytolytic T Lymphocyte Recognition of Metastatic Cancers
GEO Series GSE179897. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expression profiling of rat MHC and NKC genes in skin explant assays reveals genes that are regulated in GVHD
GEO Series GSE17928. Rattus norvegicus. 24 samples. Type: Expression profiling by array.
Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_IFN]
GEO Series GSE53467. Mus musculus. 6 samples. Type: Expression profiling by array.
MHC Class I antibody induced gene expression in mouse obliterative airway disease
GEO Series GSE71426. Mus musculus. 24 samples. Type: Expression profiling by array.
Multi-omics analysis identifies erythroid cells as the major population in mouse placentas expressing the MHC class II antigen presentation, chemokine, and antibacterial immune response genes [Nanostr
GEO Series GSE289020. Mus musculus. 12 samples. Type: Expression profiling by array.
NLRC5 is a transcriptional regulator of MHC class I genes
GEO Series GSE22064. Homo sapiens. 5 samples. Type: Expression profiling by array.
Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes
GEO Series GSE53469. Mus musculus. 18 samples. Type: Expression profiling by array.
Gene expression profiling of skin melanophages and macrophages positive or negative for MHC class II expression
GEO Series GSE103339. Mus musculus. 12 samples. Type: Expression profiling by array.
Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas.
GEO Series GSE160610. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Expression of myeloid inflammation genes in Lung digest CD64hiSiglecF-Ly6C-MHC- macrophages from PBS-treated mice and CD64hiSiglecF-Ly6C-MHC-Lyve1+ macrophages
GEO Series GSE200558. Mus musculus. 6 samples. Type: Expression profiling by array.
Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas [DLBCL_GSK126]
GEO Series GSE160609. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.