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163
datasets available to search
ShareScore release 0.9.0
Dataset results
163 results for “MPs”
Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in Renal Transplant Patients
ClinicalTrials.gov study NCT00239083. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Extension Study Evaluating Long Term Safety and Activity of AGT-181 in Children With MPS I
ClinicalTrials.gov study NCT03071341. IPD Sharing: NO. Countries: 1. Publications: 1.
Long-term Evaluation on Height and Weight in Patients With MPS II Who Started Treatment at < 6 Years of Age
ClinicalTrials.gov study NCT02455622. IPD Sharing: YES. Countries: 8. Publications: 0.
Longitudinal Studies of Brain Structure and Function in MPS Disorders
ClinicalTrials.gov study NCT01870375. IPD Sharing: YES. Countries: 2. Publications: 26.
A Prospective Natural History Study of Mucopolysaccharidosis Type IIIB (MPS IIIB)
ClinicalTrials.gov study NCT03227042. IPD Sharing: UNDECIDED. Countries: 9. Publications: 1.
Efficacy and Safety of YW17 (Laronidase-CinnaGen) Compared to Aldurazyme® in MPS I Patients
ClinicalTrials.gov study NCT06406153. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of AAVrh10-h.SGSH Gene Therapy in Patients With Mucopolysaccharidosis Type IIIA (MPS IIIA)
ClinicalTrials.gov study NCT03612869. IPD Sharing: UNDECIDED. Countries: 5. Publications: 1.
Neurobehavioral Phenotypes in MPS III
ClinicalTrials.gov study NCT01873911. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study of Mucopolysaccharidosis Type IIIB (MPS IIIB)
ClinicalTrials.gov study NCT02493998. IPD Sharing: Not stated. Countries: 8. Publications: 1.
Gene Transfer Clinical Trial for Mucopolysaccharidosis (MPS) IIIB
ClinicalTrials.gov study NCT03315182. IPD Sharing: NO. Countries: 4. Publications: 17.
An Extension Study to Determine Safety and Efficacy for Pediatric Patients With MPS Type IIIA Disease Who Participated in Study HGT-SAN-093.
ClinicalTrials.gov study NCT02350816. IPD Sharing: YES. Countries: 7. Publications: 0.
Mucopolysaccharidosis (MPS) VI Clinical Surveillance Program (CSP)
ClinicalTrials.gov study NCT00214773. IPD Sharing: NO. Countries: 13. Publications: 1.
Efficacy and Safety of Enteric-coated Mycophenolate Sodium (EC-MPS) in de Novo Kidney Transplant Recipients
ClinicalTrials.gov study NCT00238953. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparing Physical Therapy Interventions on Craniovertebral Angle (CVA) in Cervical Myofascial Pain Syndrome (MPS)
ClinicalTrials.gov study NCT07098754. IPD Sharing: NO. Countries: 1. Publications: 13.
Safety and Dose Ranging Study of Human Insulin Receptor MAb-IDUA Fusion Protein in Adults and Children With MPS I
ClinicalTrials.gov study NCT03053089. IPD Sharing: NO. Countries: 1. Publications: 1.
RGX-111 Gene Therapy in Patients With MPS I
ClinicalTrials.gov study NCT03580083. IPD Sharing: NO. Countries: 3. Publications: 1.
Data from: Assessment of dysmyelination with RAFFn MRI: application to murine MPS I
Type I mucopolysaccharidosis (MPS I) is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn), as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice and heterozygotes using RAFF5 and histology. RAFF5 (i.e., RAFFn with n = 5) relaxation time constants were highly correlated with histological myelin density (R2 = 0.68, P<0.001), and RAFF5 clearly distinguished between the hypomyelinated and dysmyelinated shiverer mouse and the wild-type mouse. Bloch-McConnell theoretical analysis revealed slower exchange correlation times and smaller exchange-induced relaxation rate constants for RAFF4 and RAFF5 compared to RAFF1-3, T1ρ, and T2ρ. These data suggest that RAFF5 may assess methylene protons in myelin lipids and proteins, though other mechanisms (e.g. detection of myelin-bound water) may also explain the sensitivity of RAFF5 to myelin. In MPS I mice, mean RAFF5 relaxation time constants were significantly larger for the striatum (P = 0.004) and internal capsule (P = 0.039), and marginally larger for the fornix (P = 0.15). Histological assessment revealed no differences between MPS I mice and heterozygotes in myelin density or corpus callosum thickness. Taken together, these findings support subtle dysmyelination in the brains of mice with MPS I. Dysmyelination may result from myelin lipid abnormalities caused by the absence of α-L-iduronidase. Our findings may help to explain locomotor and cognitive deficits seen in mice with MPS I.
Detailed Clinical Features of MPS-3A and 3B Series.
<p>Detailed Clinical Features of MPS-3A and 3B Series.</p>
Safety and Efficacy of Enteric-coated Mycophenolate Sodium (EC-MPS) Plus Valsartan in Patients With Kidney Transplants (MYTHOS
ClinicalTrials.gov study NCT00308425. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Macular Photocoagulation Study (MPS)
ClinicalTrials.gov study NCT00000158. IPD Sharing: Not stated. Countries: 0. Publications: 36.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.