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428 results for “Malformations”
Data from: Risks of 23 specific malformations associated with prenatal exposure to ten antiepileptic drugs
Objective: To assess the association between exposure to monotherapy with 10 different antiepileptic drugs (AED) during the first two months of pregnancy and the risk of 23 major congenital malformations (MCMs). Methods: This nationwide cohort study, based on the French healthcare databases, included all pregnancies&[ge]20 weeks and ending between January 2011 and March 2015. Women were considered to be exposed when an AED had been dispensed between one month before and two months after the beginning of pregnancy. The reference group included pregnant women with no reimbursement for AEDs. MCMs were detected up to 12 months after birth (24 months for microcephaly, hypospadias and epispadias). Odds ratios were adjusted for potential confounders for MCMs with at least five cases. Otherwise, we calculated crude ORs with exact confidence intervals. Results: The cohort included 1,886,825 pregnancies, 2,997 of which were exposed to lamotrigine, 1,671 to pregabalin, 980 to clonazepam, 913 to valproic acid, 579 to levetiracetam, 517 to topiramate, 512 to carbamazepine, 365 to gabapentin, 139 to oxcarbazepine and 80 to phenobarbital. Exposure to valproic acid was associated with 8 specific types of MCMs (e.g. spina bifida, OR=19.4[8.6-43.5]) and exposure to topiramate was associated with an increased risk of cleft lip (6.8[1.4-20.0]). We identified three other signals. We found no significant association for lamotrigine, levetiracetam, carbamazepine, oxcarbazepine and gabapentin. Conclusions: These results confirm the teratogenicity of valproic acid and topiramate. Because of the small numbers of cases and possible confounding, the other three signals should be interpreted with appropriate caution.
Simulation results: effects of Chiari type 1 malformation on cerebrospinal fluid dynamics during arterial pulsations and coughing
<p>The folder contains the simulation results corresponding to the computational fluid dynamics study: Effects of Chiari type 1 malformation on cerebrospinal fluid dynamics during arterial pulsations and coughing</p> <p>Data is organized in the following way with files in .csv and .xlsx format</p> <ul> <li>Cropped model: <ul> <li>output_*: flow time in seconds, pressure in the fourth ventricle (Pv), outflow in m³/s or kg/s, and pressure at plane in spinal SAS (Psas) for physical herniations and herniations created by porous zones</li> </ul> </li> <li>Full model <ul> <li>arterial_pulsations: data with all boundary conditions (arterial) except from cough</li> <li>arterial_pulsations_and_cough: data with all boundary conditions (arterial) including cough</li> <li>file content: <ul> <li>*_boundary_data: time step number, number of coupling iterations necessary per time step, flow time (s), pressure (P) and flow (Q) at outlets with interstitium (1), spinal (2), lymphatic (3) and arachnoid villi (4), first element of Jacobian (J11), flow residual, value of perturbation (dP) in Pa, converged?: 1 when converged, 0 when not, perturbation parameter, number of times the perturbation value needed to be reduced.</li> <li>*_flow: flow time in seconds, volumetric flow through aqueduct, and spinal SAS</li> <li>*_pressure_data: flow time in seconds, relative pressure compared to interstitium outlet at the fourth ventricle (v4), the spinal SAS (sas) and the lateral ventricle (lv)</li> </ul> </li> </ul> </li> </ul>
Supplementary material from: Microfluidic vessel-on-chip platform for investigation of cellular defects in venous malformations and responses to various shear stress and flow conditions
Open the record for dataset details and reuse information.
Fossilized pollen malformations as indicators of past environmental stress and meiotic disruption: insights from modern conifers
<p>Pollen malformations have been proposed as a paleoenvironmental stress proxy. However, the frequency and variability of pollen malformations under near-optimal conditions and environmental stress, as well as their developmental origins, remain unclear. To bridge these gaps, we compared pollen malformation frequencies and assemblages of 14 extant conifer genera of Pinaceae and Podocarpaceae producing saccate (winged) grains grown under near-optimal conditions. These baseline pollen yields were compared with those produced by <i>Pinus mugo</i> 'Columnaris' cultured under an abiotic stress—three experimentally heightened UV-B regimes proposed for the end-Permian crisis. We additionally reviewed previous cytological literature of abnormal microsporogenesis in conifers. Under near-optimal conditions, malformations comprise <3% of pollen yields in 12 out of 13 bisaccate genera and >10% of yields in the naturally trisaccate <i>Dacrycarpus dacrydioides</i>. We detected no phylogenetic pattern in malformation assemblages of the baseline comparisons. UV-B irradiated <i>P. mugo</i> produced significantly higher malformation frequencies and different assemblage compositions when compared with baseline bisaccate lineages. We propose that pollen malformations originate during the meiotic and tetrad stages of microsporogenesis and present a framework for the ontogeny of different malformation types seen in the fossil record. Malformations comprising >3% of bisaccate pollen yields can be used as a paleoenvironmental stress proxy, but rare, naturally trisaccate lineages are not suitable for such assessments. Furthermore, heightened UV-B not only increases pollen malformation production, but also alters the types of abnormalities trees produce. Different environmental stresses may therefore leave behind distinct fingerprints in the fossil record.</p>
Effects of medication intake on the risk of haemorrhage in patients with sporadic cerebral cavernous malformations
<p>Objective:</p> <p>Recurrent intracerebral hemorrhage (ICH) poses a high risk for patients with cerebral cavernous malformations (CCMs). This study aimed to assess the influence of medication intake on hemorrhage risk in sporadic CCMs.</p> <p>Results:</p> <p>A total of 1116 patients with CCM were included. Logistic regression analysis showed a significant correlation (OR: 0.520, 95% CI: 0.284–0.951, p = 0.034) between antithrombotic therapy and ICH as a mode of presentation. Cox regression analysis revealed no significant correlation between medication intake and occurrence of (re-)hemorrhage (hazard ratios: betablockers 1.270 [95% CI: 0.703–2.293], statins 0.543 [95% CI: 0.194–1.526], antithrombotic therapy 0.507 [95% CI: 0.182–1.410], and thyroid hormones 0.834 [95% CI: 0.378–1.839]).</p> <p>Conclusion:</p> <p>In this observational study, antithrombotic treatment was associated with the tendency to a lower rate of ICH as a mode of presentation n a large cohort of patients with sporadic CCM. Intake of beta blockers, statins, and thyroid hormones had no eect on hemorrhage as a mode of presentation. During the 5-year follow-up period, none of the drugs aected the further risk Q7 of (re-)hemorrhage.</p>
Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations Using Magnetic Resonance Imaging
ClinicalTrials.gov study NCT03995823. IPD Sharing: NO. Countries: 1. Publications: 31.
Longterm Outcomes of Individuals With Anorectal Malformations
ClinicalTrials.gov study NCT04901819. IPD Sharing: NO. Countries: 1. Publications: 4.
Treatment of Congenital Vascular Malformations Using Sirolimus: Improving Quality of Life
ClinicalTrials.gov study NCT03987152. IPD Sharing: NO. Countries: 1. Publications: 1.
Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients
ClinicalTrials.gov study NCT06437158. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Different Doses of Sirolimus for the Treatment of Cystic Lymphatic Malformations
ClinicalTrials.gov study NCT06673290. IPD Sharing: NO. Countries: 1. Publications: 8.
Risk Factors of Neonatal Respiratory Distress for Newborns With Prenatally Diagnosed Congenital Lung Malformations
ClinicalTrials.gov study NCT02352207. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Examining Different Components of Online Acceptance and Commitment Therapy for People With Chiari Malformation
ClinicalTrials.gov study NCT05581472. IPD Sharing: Not stated. Countries: 1. Publications: 28.
A Study of Direct Oral Anticoagulants in Patients with Painful Venous Malformations with Localized Intravascular Coagulation
ClinicalTrials.gov study NCT06729034. IPD Sharing: NO. Countries: 1. Publications: 1.
Diagnostic Imaging of Vascular Malformations Using MSOT and ULM
ClinicalTrials.gov study NCT06994260. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Stereo Photogrammetry Imaging in Normal Volunteers and Patients With Head and Facial Malformations
ClinicalTrials.gov study NCT00100529. IPD Sharing: Not stated. Countries: 3. Publications: 3.
Cerebral Vascular Malformations: From Multimodal Imaging, to Endovascular, Surgical or Combined Treatment
ClinicalTrials.gov study NCT05729295. IPD Sharing: NO. Countries: 1. Publications: 1.
Topical Sirolimus in Cutaneous Lymphatic Malformations
ClinicalTrials.gov study NCT03972592. IPD Sharing: NO. Countries: 1. Publications: 1.
the Efficiency of Thalidomide for Recurrent Small Intestinal Bleeding Due to Gastrointestinal Vascular Malformation
ClinicalTrials.gov study NCT02707484. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Follow-up of Children With Gastrointestinal Malformations and Postnatal Surgery
ClinicalTrials.gov study NCT01451307. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Surgical and Obstetric Outcomes in Patients With Uterine Malformations Undergoing Hysteroscopic Corrective Treatment
ClinicalTrials.gov study NCT06610864. IPD Sharing: NO. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.