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224
datasets available to search
ShareScore release 0.9.0
Dataset results
224 results for “Neurotoxicity”
Study Evaluating Neurotoxicity in Patients With Metastatic Gastro Intestinal Cancer Taking Phycocare® or Placebo During Oxaliplatin Based Chemotherapy
ClinicalTrials.gov study NCT05025826. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neurotoxicity Characterization Study of Nab-paclitaxel Versus Conventional Paclitaxel in Metastatic Breast Cancer
ClinicalTrials.gov study NCT01763710. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Protective Effect of Mangafodipir Against Oxaliplatin Neurotoxicity
ClinicalTrials.gov study NCT00727922. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Using Less Neurotoxic Drugs in Patients With HAND (MARAND-X)
ClinicalTrials.gov study NCT03163277. IPD Sharing: NO. Countries: 1. Publications: 1.
Neurofilament Light Protein in Peripheral Blood Used as a Biomarker for Neurotoxicity After Isolated Limb Perfusion.
ClinicalTrials.gov study NCT04460053. IPD Sharing: NO. Countries: 1. Publications: 2.
Association of Cefepime Trough Levels With Clinical Efficacy and Neurotoxicity in Patients With Febrile Neutropenia
ClinicalTrials.gov study NCT04250038. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Electro-acupuncture for the Prevention and Treatment of Oxaliplatin-induced Neurotoxicity in Colorectal Cancer Patients
ClinicalTrials.gov study NCT05798884. IPD Sharing: UNDECIDED. Countries: 1. Publications: 24.
Prevention of Sagopilone-induced Neurotoxicity With Acetyl-L-Carnitine (ALC)
ClinicalTrials.gov study NCT00751205. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Monosialotetrahexosylganglioside for Treatment of Oxaliplatin Induced Neurotoxicity in Gastrointestinal Cancer
ClinicalTrials.gov study NCT02486198. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Neurotoxic Effect of Sevoflurane-Based AnaesthesiaGuided by Short-Term Olfactory Identification
ClinicalTrials.gov study NCT03726580. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
ONSD and Neurotoxicity in Liver Transplant
ClinicalTrials.gov study NCT03799770. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
(1)H-Nuclear Magnetic Resonance Spectroscopic Imaging of the Brain in Patients Who Receive Neurotoxic Therapy
ClinicalTrials.gov study NCT00001807. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder
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KNIME workflows for the evaluation of neurotoxic effects in zebrafish embryos by automatic measurement of early motor behaviours
<p>Zebrafish (<em>Danio rerio</em>) has rapidly become a popular model species for behavioural studies that may be relevant to drug screening and safety toxicology. Zebrafish embryos show a complex behavioural repertoire already a few hours after fertilization. Particularly, early stage zebrafish show characteristic behavioural features such as spontaneous tail coiling (STC) or induced movements when exposed to a short and bright light flash (called photomotor response -PMR-). In this chapter, we provide the methods for assessing STC and PMR in zebrafish embryos and to detect changes provoked by chemicals. One of the protocols uses video analysis suitable for automated high-throughput screening. Moreover, both protocols describe the use of automated video analysis by using an open-source integration platform (KNIME analytics platform), providing a flexible workflow system that can be adapted to a diversity of video recordings. We also provide a toxicological validation of this assay and show that these protocols can be used to provide an automated, high data-content readout for zebrafish behavioural responses. </p>
Data from: Functional and mechanistic neurotoxicity profiling using human iPSC–derived neural 3D cultures
Neurological disorders affect millions of people worldwide and appear to be on the rise. While the reason for this increase remains unknown, environmental factors are a suspected contributor. Hence, there is an urgent need to develop more complex, biologically relevant, and predictive in vitro assays to screen larger sets of compounds with the potential for neurotoxicity. Here, we employed a human induced pluripotent stem cell (iPSC)-based 3D neural platform composed of mature cortical neurons and astrocytes as a model for this purpose. The iPSC-derived human 3D cortical neuron/astrocyte co-cultures (3D neural cultures) present spontaneous synchronized, readily detectable calcium oscillations. This advanced neural platform was optimized for high-throughput screening in 384-well plates and displays highly consistent, functional performance across different wells and plates. Characterization of oscillation profiles in 3D neural cultures was performed through multi-parametric analysis that included the calcium oscillation rate and peak width, amplitude, and waveform irregularities. Cellular and mitochondrial toxicity were assessed by high-content imaging. For assay characterization, we used a set of neuromodulators with known mechanisms of action. We then explored the neurotoxic profile of a library of 87 compounds that included pharmaceutical drugs, pesticides, flame retardants, and other chemicals. Our results demonstrated that 57% of the tested compounds exhibited effects in the assay. The compounds were then ranked according to their effective concentrations based on in vitro activity. Our results show that a human iPSC-derived 3D neural culture assay platform is a promising biologically-relevant tool to assess the neurotoxic potential of drugs and environmental toxicants.
Anakinra for the Prevention of Cytokine Release Syndrome and Neurotoxicity in Patients With B-Cell Non-Hodgkin Lymphoma Receiving CD19-Targeted CAR-T Cell Therapy
ClinicalTrials.gov study NCT04359784. IPD Sharing: NO. Countries: 1. Publications: 0.
Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy
ClinicalTrials.gov study NCT04975555. IPD Sharing: NO. Countries: 1. Publications: 0.
XENOX - Evaluation of the Efficacy of Xaliproden in Reducing the Neurotoxicity of the Oxaliplatin + 5-FU/LV Chemotherapy
ClinicalTrials.gov study NCT00272051. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Clinical and radiologic features of pediatric opioid use‐associated neurotoxicity with cerebellar edema (POUNCE) syndrome
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Data from: Functional and mechanistic neurotoxicity profiling using human iPSC–derived neural 3D cultures
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.