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71 results for “Shigella flexneri”
FIGURES 203–208 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURES 203–208. Male genitalia of Australian Ennominae. 203. Ectropis excursaria, 204. Euphronarcha epiphloea, 205. Gastrinodes bitaeniaria, 206. Phelotis cognata, 207. Scioglyptis sp. 2, 208. Syneora mundifera.
FIGURES 151–156 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURES 151–156. Antenna of male Australian Ennominae. 151. Chlenias ochrocrana, bipectinate antenna. Scale line 500 µm 152. Gastrinodes bitaeniaria, scaled rami on antenna, 153. Conosara castanaea, antenna. Scale lines 350 µm, 154. Gastrina cristaria, antenna near terminus. Scale line 150 µm, 155. Niceteria macrocosma, unipectinate antenna. Scale line 300 µm, 156. Casbia melanops, apical sensillum chaetica. Scale line 425 µm.
FIGURES 185–190 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURES 185–190. Male genitalia of Australian Nacophorini. 185. Fisera perplexata. 186. Furcatrox australis (from McQuillan 1996), 187. Gastrina cristaria, 188. Melanodes anthracitaria, 189. Mictodoca toxeuta, 190. Mnesampela privata (from McQuillan 1985),
FIGURES 209–214 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURES 209–214. Male genitalia of Ennominae. 209. Casbia melanops, 210. Rhinodia rostraria, 211. Idiodes apicata, 212. 'Metrocampa' biplaga, 213. Dissomorphia australiaria, 214. Parosteodes fictiliaria.
FIGURES 197–202 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURES 197–202. Male genitalia of Australian Ennominae. 197. Rhynchopsota delogramma, 198. Smyriodes aplectaria, 199. Stibaroma melanotoxa, 200. Thalaina selenaea, (from McQuillan 1981), 201. Cleora scriptaria, 202. Didymoctenia exsuperata.
Safety and Tolerability of a Bioconjugate Vaccine Against Shigella Flexneri 2a
ClinicalTrials.gov study NCT02388009. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Selection for phage resistance reduces virulence of Shigella flexneri
<p>There is increasing interest in phage therapy as an alternative to chemical antibiotics for treating bacterial infections, especially using phages that select for evolutionary trade-offs between increased phage resistance and decreased fitness traits such as virulence in target bacteria. A vast repertoire of virulence factors allows the opportunistic bacterial pathogen, <i>Shigella flexneri</i>, to invade human gut epithelial cells, to replicate intracellularly, and to evade host immunity through intercellular spread; the latter is an infection stage that causes tissue damage, contributing to host mortality. It is previously shown that outer membrane porin OmpA of <i>S. flexneri</i> is necessary for polar localization of virulence factor IcsA, which polymerizes host actin and results in bacterial motility within infected cells. We hypothesized that a phage which uses OmpA as a receptor to recognize, bind and infect <i>S. flexneri</i>, should select for phage-resistant mutants with attenuated intercellular spread. Here we show that a naturally-isolated <i>Myoviridae</i> virus, phage A1-1, requires OmpA as a receptor, and selects for reduced virulence in <i>S. flexneri</i>. We characterized five phage-resistant mutants by measuring their phenotypic changes relative to wildtype bacteria in various traits: cell-membrane permeability, total lipopolysaccharide (LPS), sensitivity to four antibiotics, and susceptibility to infection by phages T7 and 60B. Results separated the mutants into two groups: R1 and R2 phenotypically resembled <i>ompA</i> knockouts, whereas R3, R4 and R5 were similar to LPS-deficient strains. Whole genome sequencing confirmed that R1 and R2 had mutations in <i>ompA</i>, while R3, R4 and R5 showed mutations in LPS inner-core biosynthesis genes <i>gmhA</i> and <i>gmhC</i>. Bacterial plaque assays in Vero cells confirmed that all five phage-resistant mutants were incapable of intercellular spread. We concluded that selection for <i>S. flexneri</i> resistance to phage A1-1 generally reduced the virulence trait intercellular spread, but this trade-off could be mediated either by mutations in <i>ompA</i> or those in LPS-core genes that likely altered OmpA conformation.</p>
FIGURE 134 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURE 134. Labelled diagram of the female genitalia of the Australian nacophorine Paralaea jarrah.
A Study to Investigate the Safety and Immunogenicity of the SF2a-TT15 Synthetic Carbohydrate-based Conjugate Vaccine Against Shigella Flexneri 2a
ClinicalTrials.gov study NCT04602975. IPD Sharing: NO. Countries: 1. Publications: 0.
Shigella Flexneri 2a Invaplex 50 Vaccine Dose Finding and Assessment of Protection
ClinicalTrials.gov study NCT00485134. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Selection for phage resistance reduces virulence of Shigella flexneri
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RNA-Seq analysis of the T3SA regulon in Shigella flexneri reveals two new chromosomal genes upregulated in the on-state
GEO Series GSE123435. Shigella flexneri. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profiling of HeLa cells infected with Shigella flexneri
GEO Series GSE75746. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Safety, Immunogenicity and Efficacy Study of Inactivated Whole Cell Shigella Flexneri 2a Vaccine With and Without dmLT in Adults
ClinicalTrials.gov study NCT03038243. IPD Sharing: NO. Countries: 1. Publications: 0.
Biofilm Formation and Virulence of Shigella flexneri is Modulated by pH
GEO Series GSE183515. Shigella flexneri. 6 samples. Type: Expression profiling by high throughput sequencing.
The expression profiles analysis of a virulence plasmid-cured strain of shigella flexneri
GEO Series GSE12535. Shigella flexneri 2a str. 2457T; Shigella flexneri. 4 samples. Type: Expression profiling by array.
Expression data from Newborn mice infected with Shigella flexneri
GEO Series GSE9785. Mus musculus. 36 samples. Type: Expression profiling by array.
Cyclic di-GMP Regulates Shigella flexneri Pathogenesis
GEO Series GSE173759. Shigella flexneri 2a str. 2457T. 6 samples. Type: Expression profiling by high throughput sequencing.
Shigella flexneri ntrBC and nac mutant expression analysis
GEO Series GSE49939. Shigella flexneri; Escherichia coli K-12. 9 samples. Type: Expression profiling by array.
Expression data from wild type and deltaS4473 Shigella flexneri 2457T
GEO Series GSE40851. Shigella; Shigella flexneri 2a str. 2457T; Escherichia coli. 14 samples. Type: Expression profiling by array.
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