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ShareScore release 0.9.0
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152 results for “Smoke exposure”
Tobacco smoke exposure exacerbated crystalline silica-induced lung toxicity in rats
<p>Smoking may modify the lung response to silica exposure including cancer and silicosis. Nevertheless, the precise role of exposure to tobacco smoke (TS) on the lung response to crystalline silica (CS) exposure and the underlying mechanisms need further clarification. The objectives of the present study were to determine the role of TS on lung response to CS exposure and the underlying mechanism(s). Male Fischer 344 rats were exposed by inhalation to air, CS (15 mg/m<sup>3</sup>, 6 hrs/day, 5 days), TS (80 mg/m<sup>3</sup>, 3 hrs/day, twice weekly, 6 months), or CS (15 mg/m<sup>3</sup>, 6 hrs/day, 5 days) followed by TS (80 mg/m<sup>3</sup>, 3 hrs/day, twice weekly, 6 months). The rats were euthanized 6 months and 3 weeks following initiation of the first exposure and the lung response was assessed. Silica exposure resulted in significant lung toxicity as evidenced by lung histological changes, enhanced neutrophil infiltration, increased LDH levels, enhanced oxidant production, and increased cytokine levels. The TS exposure alone had only a minimal effect on these toxicity parameters. However, the combined exposure to TS and CS exacerbated the lung response, compared to TS or CS exposure alone. Global gene expression changes in the lungs correlated with the lung toxicity severity. Bioinformatic analysis of the gene expression data demonstrated significant enrichment in functions, pathways, and networks relevant to the response to silica exposure which correlated with the lung toxicity detected. Collectively our data demonstrated an exacerbation of CS-induced lung toxicity by TS exposure and the molecular mechanisms underlying the exacerbated toxicity.</p>
The Impact of Waterpipe Tobacco Flavors on Waterpipe Smoking Intentions, Perceptions, Patterns, and Toxicant Exposure
ClinicalTrials.gov study NCT03232827. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Smoking Exposure on Smoking Relapse Following Brief Abstinence - 2
ClinicalTrials.gov study NCT00136838. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products
ClinicalTrials.gov study NCT06179290. IPD Sharing: NO. Countries: 1. Publications: 0.
Better Asthma Outcomes: Lowering Tobacco Smoke Exposure
ClinicalTrials.gov study NCT00217958. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Effects of Parent-child Interactive Intervention in Preventing Children's Environmental Tobacco Smoke Exposure at Home
ClinicalTrials.gov study NCT02440321. IPD Sharing: Not stated. Countries: 0. Publications: 80.
Maternal Smoking Exposure and Newborn Outcomes: Study Using Urinary Cotinine
ClinicalTrials.gov study NCT07201181. IPD Sharing: Not stated. Countries: 0. Publications: 6.
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
ClinicalTrials.gov study NCT05487456. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Waterpipe Size on Smoking Behavior and Exposures
ClinicalTrials.gov study NCT05705375. IPD Sharing: NO. Countries: 1. Publications: 0.
Tobacco smoke exposure exacerbated crystalline silica-induced lung toxicity in rats
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Effect of Smoke Dye Exposure in Zebrafish Embryos
GEO Series GSE166302. Danio rerio. 93 samples. Type: Expression profiling by high throughput sequencing.
Early-life exposure to tobacco smoke alters airway signaling pathways in D. melanogaster and later mortality in D. melanogaster
GEO Series GSE205093. Drosophila melanogaster. 16 samples. Type: Expression profiling by high throughput sequencing.
Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture
GEO Series GSE135188. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Chronic exposure to waterpipe smoke elicits immunomodulatory and carcinogenic effects in the lung
GEO Series GSE197653. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Identification of differentially methylated sites in COPD by exposure to biomass smoke
GEO Series GSE268635. Homo sapiens. 90 samples. Type: Methylation profiling by genome tiling array.
Repeated Exposure to Wood Smoke Alters Pulmonary Gene and Metabolic Profiles
GEO Series GSE237251. Rattus norvegicus. 23 samples. Type: Expression profiling by high throughput sequencing.
NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure (RRBS)
GEO Series GSE133739. Mus musculus. 112 samples. Type: Methylation profiling by high throughput sequencing.
Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair response
GEO Series GSE161089. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Whole transcriptome analysis of human kidney cells after exposure to cigarette smoke extract.
GEO Series GSE182541. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression profiling of guinea pig whole-lung and hindlimb muscles following long-term exposure to cigarette smoke and/or hypoxia
GEO Series GSE51601. Cavia porcellus. 45 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.