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259 results for “Systemic Levels”
Resident self-tissue of proinflammatory cytokines rather than their systemic levels correlates with development of myelofibrosis in Gata1low mice
<p><strong>Movie 1</strong>: tridimensional image of GFP localization in the nucleus</p> <p><strong>Movie 2</strong>: tridimensional image of GFP localization in the cytoplasm</p> <p><strong>Movie 3</strong>: tridimensional reconstruction of GFPpositive cells localized around an adipocyte </p>
Resident self-tissue of proinflammatory cytokines rather than their systemic levels correlates with development of myelofibrosis in Gata1low mice
<p><strong>Figure S1. Gating used to identify endothelial cells (ECs), mesenchymal cells (MSCs), osteoblasts (OBCs), megakaryocytes (MKs) and neutrophils (Neu) in the bone marrow from a wild type mouse. </strong>In order to correctly estimate the frequency of all the cell populations, the monocellular cell suspension used for the analyses were prepared by carefully crushing the femurs of the mice (see [34] and [35] for detail).</p> <p><strong> Figure S2. (A) Example of the computer assisted image analysis used to quantify the level of fibrosis in bone marrow sections stained by Reticulin (black fibers) from representative wild-type (WT) and <em>Gata1</em><sup>low</sup> mice.</strong> The ImageJ program-assisted quantification process includes selection of the color channel (black histogram, Hue), determination of the threshold (Saturation histogram) and quantification of the areas which exceed the threshold (in %) (Brightness histogram). <strong>(B) Example of the computer assisted image analysis used to quantify the number of megakaryocytes positive per CXCR1 in in bone marrow sections from wild-type (WT) and <em>Gata1</em><sup>low</sup> mice. </strong>In this case, the conditions to quantify the signal in wild-type and <em>Gata1</em><sup>low</sup> mice were set separately. The ImageJ program-assisted quantification process includes selection of the cell type, determination of the threshold per cell (Saturation histogram) and quantification of the number of cells which exceed the threshold (Brightness histogram). Magnification 40x.</p> <p><strong>Figure S3. Levels of the proinflammatory cytokines </strong><strong>TGF-</strong><strong>β</strong><strong>1 (A), LCN2 (B) and CXCL1 (C) detected in the sera from wild-type, </strong><strong><em>Psel</em></strong><strong><sup>null</sup></strong><strong> and <em>Gata1</em><sup>low</sup><em>Psel</em><sup>null</sup> mice (all in the CD1 background).</strong> The levels of TGF-β1 in <em>Gata1</em><sup>low</sup> mice were previously reported [33] and are presented as median values from 20 mice as horizontal green line for comparison. Values are presented divided by gender (M, males; F, females) and age (adult and old). P values were calculated with Turkey’s multiple comparison test and are summarized either on the right or in <strong>Table S1</strong>. The number of mice analyzed in each experimental group is indicated by n.</p> <p><strong> Figure S4.<strong> </strong>Serum levels of pro-inflammatory cytokines (TGF-</strong><strong>β</strong><strong>1, upper panel; LCN2, middle panel; CXCL1, bottom panel) detected in CD1, C57BL/6 and DBA/2 mice</strong>. Gender (M, males; F, females) and age (adult and old) were analyzed as independent variables. The number of mice analyzed in each experimental group is indicated by n. Significant p values calculated with multiple comparison performed separately among groups from each different genotype are indicated in the graph. P values obtained with Turkey’s multiple comparison test among all groups are summarized in supplementary <strong>Tables S2-S4</strong>.</p> <p><strong> Figure S5. Hematoxylin/Eosin (H&E) and reticulin staining and TGF-β1, LCN2 and CXCL1 immunostaining of bone marrow sections from representative wild-type (WT) and <em>Gata1</em><sup>low</sup> littermates showing the fibrosis and increased cytokine bioavailability in the microenvironment of the mutant mice. </strong>Results are representative of those observed in 12-month old mice randomly selected from male and female, at least were analyzed 6 mice each staining. The arrows indicate individual megakaryocytes in wild-type mice and megakaryocyte clusters in <em>Gata1</em><sup>low</sup> mice. Magnification 40x. Similar results were previously published in Dunbar et al, 2021[11].</p> <p><strong>Figure S6</strong><em>. </em><strong>Immunohistochemical staining with (P+S) and without (S) the primary antibodies of consecutive sections from the bone marrow of WT and </strong><em>Gata1</em><sup>low</sup><strong> mice showing the specificity of the staining with the primary antibodies. </strong></p> <p><strong>Figure S7. The bone marrow from <em>Gata1</em><sup>low</sup> mice contain great levels of CXCR1. High levels of CXCR1 and CXCR2 in bone marrow sections from <em>Gata1</em><sup>low</sup> mice. A</strong>) Representative sections from the bone marrow of wild-type and <em>Gata1</em><sup>low</sup> littermates immunostained with antibodies per CXCR1 and CXCR2. Magnification 40x. <strong>B</strong>) Computer assisted quantification of the content of the CXCR1 and CXCR2 in 5 randomly selected areas per femur from three-four mice per experimental group. Statistical analysis was done by t-test and statistically significant p values among groups are indicated within the panels. Similar results were reported in Dunbar et al[11].</p> <p><strong>Figure S8</strong>. <strong>(A) Median optical slice of a confocal stack microscopy obtained with a 63x objective.</strong> The blue arrow indicates a GFP signal present inside nucleus (shown as tridimensional image in movie 1), whereas the red arrow indicates a cell were the GFP signal is localized in the cytoplasm (shown as tridimensional image in movie 2). DAPI and GFP signals are shown separately and combined. <strong>B)</strong> <strong>Hematoxylin-eosin staining (left) and fluorescent microscopy (right) of two representative sections from the bone marrow of one </strong><strong><em>huCD34-GFPH2B</em></strong><strong> mouse. </strong>The GFP staining labels either the nuclear areas of cells with small size (1, 2 and 3) or, very rarely, the cytoplasm of large cells (4), possibly macrophages. Slides were counter stained with DAPI. Magnification 40x.</p>
Replication package for: Does Pricing Carbon Mitigate Climate Change? Firm-Level Evidence from the European Union Emissions Trading System
<p>This package contains three folders: the Code folder, Results (or output) folder and the data folder. It also contains a document README.pdf . </p> <p>Part of the codes can be run with the data provided in the data folder, and have _outofbox in their name. Others can only run with confidential data - all details are provided in the README.pdf file.</p> <p>These are for the paper:</p> <p>Colmer, J., R. Martin, M. Muûls, and U.J. Wagner. Does Pricing Carbon Mitigate Climate Change? Firm-Level Evidence from the European Union Emissions Trading System</p>
Third and fourth trophic level composition shift in an aphid-parasitoid-hyperparasitoid food web limits aphid control in an intercropping system
<p>1. Understanding how resource diversification affects ecological interactions, food web structure and ecosystem functioning is essential in both fundamental and applied ecology. While plant diversification strategies (either in- or around-field) are often proposed in agricultural landscapes as practices to improve the biological control of herbivores by natural enemies, results remain variable and unsure.</p> <p>2. Here, we studied the effect of an in-field diversification practice (the intercropping of leguminous crops within cereal fields, an increasingly common practice but with inconsistent results on biological control) on cereal aphid control and the structure of a cereal-aphid-parasitoid-hyperparasitoid food web for two years.</p> <p>3. We report that aphid control was not increased in mixed fields, nor was cereal parasitoid diversity and food web complexity. Nevertheless, the provision of alternative hosts in mixed fields led to a functional community composition shift, favouring generalist parasitoid species over specialist ones.</p> <p>4. Moreover, we observed a higher hyperparasitism rate in mixed fields, suggesting that secondary parasitoids were favoured by alternative resources, which may have disrupted aphid control by primary parasitoids.</p> <p>5.<i> Synthesis and applications.</i> This study demonstrates that parasitoid community composition shift and increased top-down control by the fourth trophic level can impact parasitoid efficiency to control herbivores. These results highlight the necessity to study fine-scale mechanisms within food webs to be able to set-up efficient methods to support biodiversity and associated ecosystem services in agricultural landscapes.</p>
STROBE checklist for: Serum soluble angiotensin-converting enzyme 2 level and its potential association with the renin-angiotensin-aldosterone system in non-hypertensive covid-19 patients: an observational study
<p>Serum soluble angiotensin-converting enzyme 2 level and its potential association with the renin-angiotensin-aldosterone system in non-hypertensive covid-19 patients: an observational study</p>
Steady states of Λ-type three-level systems excited by quantum light with various photon statistics in lossy cavities
<p>Dataset of the publication "Steady states of Λ-type three-level systems excited by quantum light with various photon statistics in lossy cavities" H. Rose, O. V. Tikhonova, T. Meier, and P. R. Sharapova, New J. Phys.<strong> 24</strong>, 063020 (2022). ( https://doi.org/10.1088/1367-2630/ac74d8 ). The zip file includes the data on which the plots shown in figures 2,4,5,6,7, B1, and B2 are based.</p>
Theoretical analysis of correlations between two quantum fields exciting a three-level system using the cluster-expansion approach
<p>Dataset of the publication "Theoretical analysis of correlations between two quantum fields exciting a three-level system using the cluster-expansion approach" H. Rose, O. V. Tikhonova, T. Meier, and P. R. Sharapova, Proc. SPIE 11999, Ultrafast Phenomena and Nanophotonics XXVI, 1199905 (2022). ( https://doi.org/10.1117/12.2608528 ). The zip file includes the data on which the plots shown in figures 1, 2, and 3 are based.</p>
Effects of periodic fluctuation of water level on solute transport in seasonal lakes in Poyang floodplain system
<p>The purpose of this study is to investigate the solute transport in seasonal lakes within floodplain systems by means of laboratory experiments and numerical simulations.</p>
Treatment Efficacy of Systemic Corticosteroids in AECOPD Patients With Higher Blood Eosinophil Levels
ClinicalTrials.gov study NCT05059873. IPD Sharing: YES. Countries: 1. Publications: 9.
Additional Signals for Exercise, Stress and Sleep and Prediction of Glucose Levels for AP Systems
ClinicalTrials.gov study NCT04725799. IPD Sharing: NO. Countries: 1. Publications: 5.
Investigation of the Effects of Different Levels of Obesity on the Respiratory System
ClinicalTrials.gov study NCT04780828. IPD Sharing: UNDECIDED. Countries: 1. Publications: 36.
Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients
ClinicalTrials.gov study NCT05430087. IPD Sharing: Not stated. Countries: 1. Publications: 31.
The Effects of Prednisone on HIV Levels and the Immune System
ClinicalTrials.gov study NCT00000921. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Different End-tidal Carbon-dioxide Levels on Cerebral CO2 Vasoreactivity and the Stiffness of Systemic Arteries During Propofol Anesthesia
ClinicalTrials.gov study NCT02203097. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Evaluation of Effects of Bracket's Slot System on the Quantity and Quality of Teeth Movements During Orthodontic Leveling and Alignment Stage
ClinicalTrials.gov study NCT05537506. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Circulating microRNA 21 Expression Level Before and After Neoadjuvant Systemic Therapy in Breast Carcinoma
ClinicalTrials.gov study NCT05151224. IPD Sharing: NO. Countries: 1. Publications: 11.
Appropriateness of Methodist Health System(MHS) Inter-facility Transfers of Traumatic Intracranial Subarachnoid Hemorrhage and Spontaneous Bleeds for Level-1 Advanced Surgical Intervention
ClinicalTrials.gov study NCT06136078. IPD Sharing: YES. Countries: 1. Publications: 1.
Determination of Levels of Micafungin in Neonates Suffering From Systemic Candidiasis and/or Candida Meningitis
ClinicalTrials.gov study NCT03421002. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effect of Renin Angiotensin System Blockage (RAS) Blockade On PTX3 Levels In Diabetic Patients With Proteinuria
ClinicalTrials.gov study NCT00674596. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Development of Pneumonia Due to Alveolar Glucose Levels in Systemic Hyperglycemia
ClinicalTrials.gov study NCT03577964. IPD Sharing: NO. Countries: 1. Publications: 4.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.