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ShareScore release 0.9.0
Dataset results
109 results for “TERT”
Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer [ChIP-Seq - EBF1, EZH2]
GEO Series GSE121495. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide analysis of TERT-AD mouse cortical and hippocampal neurons upon Tert activation
GEO Series GSE163523. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Gene expression analysis during adipocytic differentiation of human bone marrow cells (hMSC-TERT)
GEO Series GSE59450. Homo sapiens. 6 samples. Type: Expression profiling by array.
Telomerase subunit TERT regulates MYC stability independent of its role on telomeres (array)
GEO Series GSE60175. Homo sapiens. 6 samples. Type: Expression profiling by array.
Discovery of TERT isoforms by Long read RNA seq
GEO Series GSE279325. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Exposure to tert-butylphenyl diphenyl phosphate, an organophosphate ester flame retardant and plasticizer, alters hedgehog signaling in ex vivo murine limb bud cultures
GEO Series GSE155435. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
A mechanistic classification of clinical phenotypes in neuroblastoma (TERT expression threshold cohort)
GEO Series GSE120568. Homo sapiens. 186 samples. Type: Expression profiling by array.
Genomic analysis of mice with endothelium-specific TERT knockout (RNA-Seq)
GEO Series GSE239686. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Gene expression changes of tert-butyl alchol-induced in renal cortex of rats
GEO Series GSE87278. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
RNA-seq analysis of the effect of loss of Tp53, NF1 or CBS in telomerase-reverse transcriptase (TERT)-immortalized human BJ fibroblasts (BJ-TERT) overexpressing myristoylated AKT1
GEO Series GSE200479. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer [Chip-Seq + RNA-Seq]
GEO Series GSE144714. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
TERT activates endogenous retroviruses contributing to immunosuppressive tumour microenvironment I
GEO Series GSE169711. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
microRNA expression profiling during Adipocytic differentiation of human MSCs (hMSC-TERT)
GEO Series GSE59684. synthetic construct; Homo sapiens. 9 samples. Type: Non-coding RNA profiling by array.
Data from: A telomerase with novel non-canonical roles: TERT controls cellular aggregation and tissue size in Dictyostelium
Telomerase, particularly its main subunit, the reverse transcriptase, TERT, prevents DNA erosion during eukaryotic chromosomal replication, but also has poorly understood non-canonical functions. Here, in the model social amoeba Dictyostelium discoideum, we show that the protein encoded by tert has telomerase-like motifs, and regulates, non-canonically, important developmental processes. Expression levels of wild-type (WT) tert were biphasic, peaking at 8 and 12 h post-starvation, aligning with developmental events, such as the initiation of streaming (~7 h) and mound formation (~10 h). In tert KO mutants, however, aggregation was delayed until 16 h. Large, irregular streams formed, then broke up, forming small mounds. The mound-size defect was not induced when a KO mutant of countin (a master size-regulating gene) was treated with TERT inhibitors, but anti-countin antibodies did rescue size in the tert KO. Although, conditioned medium (CM) from countin mutants failed to rescue size in the tert KO, tert KO CM rescued the countin KO phenotype. These and additional observations indicate that TERT acts upstream of smlA/countin: (i) the observed expression levels of smlA and countin, being respectively lower and higher (than WT) in the tert KO; (ii) the levels of known size-regulation intermediates, glucose (low) and adenosine (high), in the tert mutant, and the size defect's rescue by supplemented glucose or the adenosine-antagonist, caffeine; (iii) the induction of the size defect in the WT by tert KO CM and TERT inhibitors. The tert KO's other defects (delayed aggregation, irregular streaming) were associated with changes to cAMP-regulated processes (e.g. chemotaxis, cAMP pulsing) and their regulatory factors (e.g. cAMP; acaA, carA expression). Overexpression of WT tert in the tert KO rescued these defects (and size), and restored a single cAMP signaling centre. Our results indicate that TERT acts in novel, non-canonical and upstream ways, regulating key developmental events in Dictyostelium.
Influence of Alkali Metal Cations in the Formation of the Heterobimetallic Actinide tert-Butoxides [AnM3(OtBu)7] and [AnM2(OtBu)6] (AnIV = Th, U; MI = Li, Na, K, Rb, Cs)
<p>These are the raw data the compound <strong>ThNa3</strong>, refined as an inversion twin. The following is the abstract of the corresponding paper.</p> <p>Heterobimetallic <em>tert</em>-butoxides of alkali metal cations and tetravalent actinide centers exhibit two distinctive structural motifs, [AnM<sub>2</sub>(O<em><sup>t</sup></em>Bu)<sub>6</sub>] and [AnM<sub>3</sub>(O<em><sup>t</sup></em>Bu)<sub>7</sub>] (An<sup>IV</sup> = Th, U and M<sup>I</sup> = Li, Na, K, Rb, Cs), evidently govern by the size of the alkali metal ions. Both [AnM<sub>3</sub>(O<em><sup>t</sup></em>Bu)<sub>7</sub>] <strong>AnM3 </strong>(An<sup>IV</sup> = U, M<sup>I</sup> = Li; An<sup>IV</sup> = Th, M<sup>I</sup> = Li, Na) and<strong> </strong>[AnM<sub>2</sub>(O<em><sup>t</sup></em>Bu)<sub>6</sub>] <strong>AnM2</strong> (An<sup>IV</sup> = U, M<sup>I</sup> = Na – Cs; An<sup>IV</sup> = Th, M<sup>I</sup> = K - Cs) compounds are obtained in nearly quantitative yields by reacting the actinide and alkali metal silyl amides with excess of <em>tert</em>-butyl alcohol. The <strong>AnM3</strong> complexes form a cubane-type coordination motif, whereas the <strong>AnM2</strong> complexes display a geometry resembling two face-shared bipyramids. The sodium derivatives of thorium and uranium (<strong>ThNa3</strong> and <strong>UNa2</strong>) allow to determine the structural transition threshold as function of the ratio of the ionic radii, r<sub>i</sub>(An<sup>IV</sup>)/r<sub>i</sub>(M<sup>I</sup>). The <strong>AnM3</strong> complexes are formed for ratios above 0.92 and the <strong>AnM2</strong> type is formed for ratios below 0.87. All compounds are unambiguously characterized in both solution and the solid-state via NMR and IR spectroscopic studies and single crystal X-ray diffraction analyses, respectively.</p>
The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients
ClinicalTrials.gov study NCT02011906. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study on the Bioequivalence of Perindopril Tert-butylamine Tablets Taken on After Meals in Healthy Subjects
ClinicalTrials.gov study NCT04556110. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Evaluation of Genetron TERT PCR Kit in Glioma Patients
ClinicalTrials.gov study NCT05100602. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study on the Bioequivalence of Perindopril Tert-butylamine Tablets Taken on an Empty Stomach in Healthy Subjects
ClinicalTrials.gov study NCT04556058. IPD Sharing: NO. Countries: 1. Publications: 0.
Bioequivalence Study of 8 mg Perindopril Tert-Butylamine / 2.5 mg Indapamide / 10 mg Amlodipine Tablets Versus 10 mg Perindopril Arginine / 2.5 mg Indapamide / 10 mg Amlodipine Film-Coated Tablets in
ClinicalTrials.gov study NCT05470764. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.