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897
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ShareScore release 0.9.0
Dataset results
897 results for “Therapeutic targets”
HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network
ClinicalTrials.gov study NCT01474811. IPD Sharing: Not stated. Countries: 4. Publications: 7.
Therapeutic Drug Monitoring - Targeting IMproved Effectiveness
ClinicalTrials.gov study NCT05971979. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery
ClinicalTrials.gov study NCT02716285. IPD Sharing: NO. Countries: 1. Publications: 8.
Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease
ClinicalTrials.gov study NCT04643327. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets
ClinicalTrials.gov study NCT04806282. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Nuclear Myosin VI - a Therapeutic Target in Breast Cancer
ClinicalTrials.gov study NCT03430024. IPD Sharing: NO. Countries: 1. Publications: 8.
Genotype Expression and Phenotype of Endothelial Cells, Carrying an ACVRL1, ENG or SMAD4 Mutation, in Response to BMP9 for the Identification of New Therapeutic Targets in Hereditary Haemorrhagic Tela
ClinicalTrials.gov study NCT05632484. IPD Sharing: NO. Countries: 1. Publications: 2.
Centers for Education on Research and Therapeutics - Heart Failure: Targeted Intervention Study
ClinicalTrials.gov study NCT00979264. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest
ClinicalTrials.gov study NCT03114033. IPD Sharing: UNDECIDED. Countries: 14. Publications: 5.
Identifying New Therapeutic Targets for Lupus Treatment
ClinicalTrials.gov study NCT03921398. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Changes in Phenotype and Genotype of Breast Cancers During the Metastatic Process and Optimization of Therapeutic Targeting (ESOPE)
ClinicalTrials.gov study NCT01956552. IPD Sharing: YES. Countries: 1. Publications: 1.
Newer Therapeutic Targets in Head and Neck Cancers
ClinicalTrials.gov study NCT05382585. IPD Sharing: YES. Countries: 1. Publications: 1.
Neuroprotective Therapy and Therapeutic Target in Emergency Department
ClinicalTrials.gov study NCT02143596. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Selenoproteins as Prognostic Markers and Therapeutic Targets in Breast Cancer.
ClinicalTrials.gov study NCT05817227. IPD Sharing: Not stated. Countries: 1. Publications: 22.
TS Overexpression in SCLC: Mechanism and Therapeutic Targeting
ClinicalTrials.gov study NCT03741829. IPD Sharing: NO. Countries: 1. Publications: 9.
Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni
<p><span><span><span><span><span><span><span><span><span><span><span>Schistosomes kill 250,000 people every year. Treatment of schistosomiasis relies on a single drug (praziquantel). Unfortunately, a scarcity of molecular tools has hindered the discovery of new drug targets. Here, we describe a large-scale RNA interference screen in adult Schistosoma mansoni examining the function of 2,216 genes. We discovered 250 genes with phenotypes affecting neuromuscular function, tissue integrity, stem cell maintenance, and parasite survival. Leveraging these data, we prioritize compounds with activity against the parasites and uncover a pair of protein kinases (TAO and STK25) that cooperate to maintain muscle-specific mRNA transcription. Loss of either of these kinases results in paralysis and worm death in a mammalian host. These studies will expedite therapeutic development and invigorate studies of these neglected parasites. Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni.</span></span></span></span></span></span></span></span></span></span></span></p> <p> </p>
Computational Evidence for Bisartan Arginine Blockers as Next-Generation Pan-Antiviral Therapeutics Targeting SARS-CoV-2, Influenza, and Respiratory Syncytial Viruses (RawData)
Open the record for dataset details and reuse information.
Proteome-wide Mendelian randomization study identifies potential therapeutic targets for Coronary atherosclerosis
Open the record for dataset details and reuse information.
Thrombo-inflammation in Acute Neurovascular Diseases: Definition of New Therapeutic Targets (TARGETS)
ClinicalTrials.gov study NCT07354321. IPD Sharing: UNDECIDED. Countries: 0. Publications: 15.
Identifying Therapeutic Targets of Accelerated Sarcopenia
ClinicalTrials.gov study NCT03118050. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.