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54
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ShareScore release 0.9.0
Dataset results
54 results for “Thoracic aneurysms.”
Prospective Evaluation of the Biomechanical Properties of the Thoracic Aorta Coupling Magnetic Resonance Imaging and In-vitro Elasticity Tests in Patients With Ascending Aortic Aneurysm
ClinicalTrials.gov study NCT03746964. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique
ClinicalTrials.gov study NCT01107366. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm
ClinicalTrials.gov study NCT02256163. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mitochondrial NAD+ deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm
GEO Series GSE235161. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA sequencing for normal and Angiotensin Ⅱ-induced thoracic and abdominal aneurysmal aorta
GEO Series GSE221789. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene Expression Signature in Peripheral Blood Detects Thoracic Aortic Aneurysm
GEO Series GSE9106. Homo sapiens. 179 samples. Type: Expression profiling by array; Expression profiling by RT-PCR.
Fibrillin-1 regulated miR-122 has a critical role in thoracic aortic aneurysm formation
GEO Series GSE199285. synthetic construct; Mus musculus. 24 samples. Type: Non-coding RNA profiling by array; Expression profiling by array.
Evaluation of Thoraflex in the Treatment of Aneurysm or Penetrating Ulcer of the Descending Thoracic Aorta
ClinicalTrials.gov study NCT01357590. IPD Sharing: Not stated. Countries: 7. Publications: 0.
S100A4-lineage Cells Contribute Modesty to Angiotensin II-mediated Thoracic Aortic Aneurysms Through Angiotensin II Type 1a Receptor in Mice
GEO Series GSE309042. Mus musculus. 86 samples. Type: Expression profiling by high throughput sequencing.
Vascular smooth muscle cell senescence instigates thoracic aortic aneurysm
GEO Series GSE143921. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
MMP19 in vascular smooth muscle cells protects against thoracic aortic aneurysm and dissection via the MMP19/Aggrecan/Wnt/β-Catenin axis
GEO Series GSE287828. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Cyclophilin A/EMMPRIN Axis Is Involved in Pro-Fibrotic Processes Associated with Thoracic Aortic Aneurysm of Marfan Syndrome Patients
<p>Abstract: Background: Marfan syndrome (MFS) is a genetic disease, characterized by thoracic aortic aneurysm (TAA), which treatment is to date purely surgical. Understanding of novel molecular targets is mandatory to unveil effective pharmacological approaches. Cyclophilin A (CyPA) and its receptor EMMPRIN are associated with several cardiovascular diseases, including abdominal aortic aneurysm. Here, we envisioned the contribution of CyPA/EMMPRIN axis in MFS-related TAA. Methods: We obtained thoracic aortic samples from healthy controls (HC) and MFS patients’ aortas and then isolated vascular smooth muscle cells (VSMC) from the aortic wall. Results: our findings revealed that MFS aortic tissue samples isolated from the dilated zone of aorta showed higher expression levels of EMMPRIN vs. MFS non-dilated aorta and HC. Interestingly, angiotensin II significantly stimulated CyPA secretion in MFS-derived VSMC (MFS-VSMC). CyPA treatment on MFS-VSMC led to increased levels of EMMPRIN and other MFS-associated pro-fibrotic mediators, such as TGF-β1 and collagen I. These molecules were downregulated by in vitro treatment with CyPA inhibitor MM284. Our results suggest that CyPA/EMMPRIN axis is involved in MFS-related TAA development, since EMMPRIN is upregulated in the dilated zone of MFS patients’ TAA and the inhibition of its ligand, CyPA, downregulated EMMPRIN and MFS-related markers in MFS-VSMC. Conclusions: these insights suggest both a novel detrimental role for CyPA/EMMPRIN axis and its inhibition as a potential therapeutic strategy for MFS-related TAA treatment.</p>
Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells
GEO Series GSE290902. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
DataSet_Simultaneous versus staged approach in transcatheter aortic valve implantation for severe stenosis and endovascular aortic repair for thoracic and abdominal aortic aneurysm
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.