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454
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ShareScore release 0.9.0
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454 results for “Tissue-specific”
Data from: Tissue-specific carbon concentration, carbon stock, and distribution in Cunninghamia lanceolata (Lamb.) Hookplantations at various developmental stages in subtropical China
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Data from: Insulin signaling's role in mediating tissue-specific nutritional plasticity and robustness in the horn-polyphenic beetle Onthophagus taurus
Organisms cope with nutritional variation via developmental plasticity, adjusting trait size to nutrient availability for some traits while enabling others to develop in a nutritionally robust manner. Yet, the developmental mechanisms that regulate organ-specific growth across nutritional gradients remain poorly understood. We assessed the functions of members of the insulin/insulin-like signaling pathway (IIS) in the regulation of nutrition sensitivity and robustness in males of the horn-polyphenic beetle Onthophagus taurus, as well as potential regulatory interactions between IIS and two other growth-regulating pathways: Doublesex and Hedgehog signaling. Using RNA interference (RNAi) we experimentally knocked down both insulin receptors (InR1, InR2) and Foxo, a growth inhibitor. We then performed morphometric measurements on horns, a highly nutrition-sensitive trait, and genitalia, a largely nutrition-insensitive trait. Finally, we used qRT-PCR to assess expression levels of Doublesex and the Hedgehog-signaling gene smoothened following IIS-RNAi. Our results suggest that nutrition responsiveness of both traits is regulated by different IIS components, which transduce nutritional conditions to both Doublesex and Hedgehog pathways, albeit via different IIS pathway members. Combined with previous studies our findings suggest that separate origins of trait exaggeration among insect lineages were enabled through the independent cooption of IIS, yet via reliance on different components therein.
Data from: Systems biology of tissue-specific response to Anaplasma phagocytophilum reveals differentiated apoptosis in the tick vector Ixodes scapularis
Anaplasma phagocytophilum is an emerging pathogen that causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects cell function in both vertebrate host and the tick vector, Ixodes scapularis. Global tissue-specific response and apoptosis signaling pathways were characterized in I. scapularis nymphs and adult female midguts and salivary glands infected with A. phagocytophilum using a systems biology approach combining transcriptomics and proteomics. Apoptosis was selected for pathway-focused analysis due to its role in bacterial infection of tick cells. The results showed tissue-specific differences in tick response to infection and revealed differentiated regulation of apoptosis pathways. The impact of bacterial infection was more pronounced in tick nymphs and midguts than in salivary glands, probably reflecting bacterial developmental cycle. All apoptosis pathways described in other organisms were identified in I. scapularis, except for the absence of the Perforin ortholog. Functional characterization using RNA interference showed that Porin knockdown significantly increases tick colonization by A. phagocytophilum. Infection with A. phagocytophilum produced complex tissue-specific alterations in transcript and protein levels. In tick nymphs, the results suggested a possible effect of bacterial infection on the inhibition of tick immune response. In tick midguts, the results suggested that A. phagocytophilum infection inhibited cell apoptosis to facilitate and establish infection through up-regulation of the JAK/STAT pathway. Bacterial infection inhibited the intrinsic apoptosis pathway in tick salivary glands by down-regulating Porin expression that resulted in the inhibition of Cytochrome c release as the anti-apoptotic mechanism to facilitate bacterial infection. However, tick salivary glands may promote apoptosis to limit bacterial infection through induction of the extrinsic apoptosis pathway. These dynamic changes in response to A. phagocytophilum in I. scapularis tissue-specific transcriptome and proteome demonstrated the complexity of the tick response to infection and will contribute to characterize gene regulation in ticks.
Comprehensive characterization of HNF4A and HNF1A genomic targets in pancreatic beta cells and hepatic cells reveals common and tissue-specific gene regulation
<p>Molecular dynamics simulation input files, initial and final coordinate files</p>
Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens Into the Human Lung
ClinicalTrials.gov study NCT05027958. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster
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Data from: Insulin signaling’s role in mediating tissue-specific nutritional plasticity and robustness in the horn-polyphenic beetle Onthophagus taurus
Open the record for dataset details and reuse information.
Data from: Systems biology of tissue-specific response to Anaplasma phagocytophilum reveals differentiated apoptosis in the tick vector Ixodes scapularis
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Data from: Tissue-specific changes in apoplastic proteins and cell wall structure during cold acclimation of winter wheat crowns
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Data from: Freeze-quenched maize mesophyll and bundle sheath separation uncovers bias in previous tissue-specific RNA-Seq data
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Tissue-specific transcriptomic changes associated with AmBisome treatment of mice with experimental visceral leishmaniasis
GEO Series GSE138825. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
The Transcription factor Zeb2 ia required to maintain tissue-specific identities of macrophages [microarray]
GEO Series GSE117080. Mus musculus. 7 samples. Type: Expression profiling by array; Third-party reanalysis.
Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb.
GEO Series GSE30641. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Drosophila CLOCK Target Gene Characterization: Implications for Circadian Tissue-Specific Gene Expression
GEO Series GSE32613. Drosophila melanogaster. 21 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Circulating cell-free, methylated DNA reveals tissue-specific, cellular damage from radiation treatment [Mouse Reference Cell-type MCC-seq]
GEO Series GSE200185. Mus musculus. 8 samples. Type: Methylation profiling by high throughput sequencing.
Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin
GEO Series GSE63979. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
SRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program
GEO Series GSE303179. Mus musculus; Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Clustering of tissue-specific sub-TADs accompanies the regulation of HoxA genes in developing limbs
GEO Series GSE52483. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Tissue-specific transcriptomic profiling of Sorghum propinquum using a rice genome array
GEO Series GSE40380. Oryza sativa; Sorghum propinquum. 15 samples. Type: Expression profiling by array.
Two promoter types induce tissue-specific effector genes in the late Drosophila embryo [RNA-Seq]
GEO Series GSE120155. Drosophila melanogaster. 11 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.