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56
datasets available to search
ShareScore release 0.9.0
Dataset results
56 results for “Vascular dementia”
Efficacy and Safety of Cilostazol in Patients of Vascular Cognitive Impairment-no Dementia (VCIND)
ClinicalTrials.gov study NCT01872858. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Influence of Vascular Burden, Amyloid Plaque and Tau Protein in Patients With Vascular Cognitive Impairment and Dementia With Tauopathy
ClinicalTrials.gov study NCT04309253. IPD Sharing: Not stated. Countries: 1. Publications: 0.
BAC in Patient With Alzheimer's Disease or Vascular Dementia
ClinicalTrials.gov study NCT02467413. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Donepezil Hydrochloride (Aricept) in Vascular Dementia
ClinicalTrials.gov study NCT00165763. IPD Sharing: Not stated. Countries: 1. Publications: 0.
SIVD (Subcortical Ischemic Vascular Dementia)
Open the record for dataset details and reuse information.
Trimethylamine N-oxide Aggravates Neuro-inflammation via lncRNA Fendrr/miR-145-5p/PXN axis in Vascular Dementia Rats
GEO Series GSE249873. Rattus norvegicus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Integrated transcriptome and metabolome analysis of mechanism on intranasal spray insulin against vascular dementia
GEO Series GSE228174. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling of miRNA and mRNA of the cortex in a rat model of Vascular dementia by RNA-sequencing
GEO Series GSE199508. Rattus norvegicus. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
A Placebo-controlled Trial to Evaluate the Safety and Efficacy of Galantamine in the Treatment of Vascular Dementia
ClinicalTrials.gov study NCT00035191. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Rivastigmine Capsules in Patients With Probable Vascular Dementia
ClinicalTrials.gov study NCT00130338. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Deconstructing the Intercellular Interactome in Vascular Dementia with Focal Ischemia for Therapeutic Applications
GEO Series GSE298799. Mus musculus. 77 samples. Type: Expression profiling by high throughput sequencing.
Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia [snRNA-Seq]
GEO Series GSE282111. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia [scRNA-Seq]
GEO Series GSE282112. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Multi-Omics Integration Implicates Rac/Rho GTPase Cycling in Vascular Cognitive Impairment and Dementia Pathogenesis
GEO Series GSE303449. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Antibody-neutralizable major early driver of Alzheimer’s disease and vascular dementia
GEO Series GSE126815. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Vascular lesions and brain atrophy in Alzheimer's, vascular and mixed dementia: an optimized 3T MRI protocol reveals distinctive radiological profiles
<p><strong>Background</strong></p> <p>Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the</p> <p>BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in</p> <p>terms of cerebrospinal fluid (CSF) tau and brain atrophy.</p> <p><strong>Methods</strong></p> <p>Seventy-six subjects received a diagnosis of Alzheimer’s (AD=32), vascular (VD=26) or mixed (MD=18) dementia according to Hachinski scale and NINCDS-ADRDA criteria. Three independent raters assessed the brain images acquired according to a high resolution 3T MRI protocol (including 3D FLAIR, T1, SWI and 2D coronal T2 sequences) with semiquantitative scales for vascular lesions (periventricular and deep white matter lesions, PVL and DWML, deep grey matter lesions, DGML, enlarged perivascular spaces, PVS, and microbleeds, MB) and brain atrophy (medial temporal atrophy, MTA, posterior atrophy, PA, global cortical atrophy-frontal, GCA-F, and Evans’ index). The inter-rater agreement was assessed with the intraclass correlation coefficient (ICC).</p> <p><strong>Results</strong></p> <p>Raters reached a good-to-excellent agreement for all scales (ICC ranging 0.78-0.96). A greater number of PVL (p<0.001), DWML (p<0.001), DGML (p=0.010) and PVS (p=0.001) was observed in VD compared to AD, while MD showed a significant greater number of PVL (p=0.001), DWML (p=0.002), DGML (p=0.018) and deep and juxtacortical MB (p=0.006 and p<0.001, respectively). No significant difference was observed in scores of cortical atrophy scales and Evans’ index among the three groups.</p> <p><strong>Conclusion</strong></p> <p>The use of a high-resolution 3T MRI protocol, including SWI, allowed a reliable and time-saving assessment of vascular lesions and atrophy using dedicated visual scales. Our findings confirm that white and grey matter lesions are the predominant abnormalities in both vascular and mixed dementia, whereas juxtacortical microbleeds predominate in mixed dementia, suggesting that cerebral amyloid angiopathy could be the main underlying pathology.</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.