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Dataset results
212 results for “Zika”
VRC 320: A Phase I, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA090-00-VP, Administered Via Needle and Syringe or Needle-free Injector, P
ClinicalTrials.gov study NCT02996461. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
ClinicalTrials.gov study NCT02943304. IPD Sharing: NO. Countries: 1. Publications: 1.
Zika and Microcephaly: Case-control Study
ClinicalTrials.gov study NCT02741882. IPD Sharing: NO. Countries: 1. Publications: 1.
The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico
ClinicalTrials.gov study NCT02831699. IPD Sharing: NO. Countries: 1. Publications: 3.
Zika Virus Purified Inactivated Vaccine (ZPIV) Accelerated Vaccination Schedule Study
ClinicalTrials.gov study NCT02937233. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Zika and Neurodevelopment Among Infants in Grenada
ClinicalTrials.gov study NCT04697147. IPD Sharing: NO. Countries: 1. Publications: 1.
Persistence of Zika Virus in Semen After Acute Infection
ClinicalTrials.gov study NCT02733796. IPD Sharing: YES. Countries: 1. Publications: 8.
Zika Virus Infection's Pregnancy Consequences in French Department of America
ClinicalTrials.gov study NCT02916732. IPD Sharing: NO. Countries: 3. Publications: 2.
Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil
ClinicalTrials.gov study NCT03106714. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD)
ClinicalTrials.gov study NCT02794181. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ZAP affects Zika virus RNA interactome - Table S1-ChIRP-MS data
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ZAP affects Zika virus RNA interactome- supplemental datasets 1 and 2
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Data from: Comparative genomics, infectivity and cytopathogenicity of Zika viruses produced by acutely and persistently Zika virus-infected human hematopoietic cell lines
Zika virus (ZIKV), an arthropod-borne virus, has emerged as a major human pathogen. Prolonged or persistent ZIKV infection of human cells and tissues may serve as a reservoir for the virus and present serious challenges to the safety of public health. Human hematopoietic cell lines with different developmental properties revealed differences in susceptibility and outcomes to ZIKV infection. In 3 separate studies involving the prototypic MR 766 ZIKV strain and the human monocytic leukemia U937 cell line, ZIKV initially developed only a low-grade infection at a slow rate. After continuous culture for several months, persistently ZIKV-infected cell lines were observed with most, if not all, cells testing positive for ZIKV antigen. The infected cultures produced ZIKV RNA (v-RNA) and infectious ZIKVs persistently ("persistent ZIKVs") with distinct infectivity and pathogenicity when tested using various kinds of host cells. When the genomes of ZIKVs from the three persistently infected cell lines were compared with the genome of the prototypic MR 766 ZIKV strain, distinct sets of mutations specific to each cell line were found. Significantly, all three "persistent ZIKVs" were capable of infecting fresh U937 cells with high efficiency at rapid rates, resulting in the development of a new set of persistently ZIKV-infected U937 cell lines. The genomes of ZIKVs from the new set of persistently ZIKV-infected U937 cell lines were further analyzed for their different mutations. The 2nd generation of persistent ZIKVs continued to possess most of the distinct sets of mutations specific to the respective 1st generation of persistent ZIKVs. We anticipate that the study will contribute to the understanding of the fundamental biology of adaptive mutations and selection during viral persistence. The persistently ZIKV-infected human cell lines that we developed will also be useful to investigate critical molecular pathways of ZIKV persistence and to study drugs or countermeasures against ZIKV infections and transmission.
Data from: Zika virus in the Americas: early epidemiological and genetic findings
Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015 and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. Using next generation sequencing we generated seven Brazilian ZIKV genomes, sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, estimated to have occurred between May-Dec 2013, more than 12 months prior to the detection of ZIKV in Brazil. The estimated date of origin coincides with an increase in air passengers to Brazil from ZIKV endemic areas, and with reported outbreaks in Pacific Islands. ZIKV genomes from Brazil are phylogenetically interspersed with those from other South American and Caribbean countries. Mapping mutations onto existing structural models revealed the context of viral amino acid changes present in the outbreak lineage; however no shared amino acid changes were found among the three currently available virus genomes from microcephaly cases. Municipality-level incidence data indicate that reports of suspected microcephaly in Brazil best correlate with ZIKV incidence around week 17 of pregnancy, although this does not demonstrate causation. Our genetic description and analysis of ZIKV isolates in Brazil provide a baseline for future studies of the evolution and molecular epidemiology in the Americas of this emerging virus.
Raw data for the article: Oncolytic Effect of Zika Virus in Neuroendocrine Pancreatic Tumors: New Perspectives for Therapeutic Approaches
<p>Pancreatic cancer (PCa) is the fifth leading cause of cancer mortality. Recently, our group and others have demonstrated the oncolytic activity of the Zika virus (ZIKV) against glioblastoma. The peculiar features of this virus offer the opportunity to use an agent already tested in vivo through natural transmission, with minimal effects on adults, to specifically target a tumor such as glioblastoma. This remarkable specificity prompted us to explore the potential use of ZIKV oncolytic action against other tumor types. In particular, we focused on the subgroup of pancreatic tumors with a neuroendocrine origin known as neuroendocrine tumors (NETs). We found that ZIKV exerts its oncolytic activity by specifically infecting NET cells, leading to growth inhibition and cell death. We also assessed whether the oncolytic action could be extended to pancreatic tumors different from NETs. However, as expected, the viral specificity is limited to NETs and is not applicable to adenocarcinoma tumors, indicating a narrow spectrum of action for this virus. These findings support the potential use of ZIKV in therapeutic approaches not only in glioblastoma, but also against other tumors, such as neuroendocrine pancreatic tumors.</p>
Raw data for the article: Two Sides of The Same Coin: Normal and Tumoral Stem Cells, The Relevance of In Vitro Models and Therapeutic Approaches: The Experience with Zika Virus in Nervous System Development and Glioblastoma Treatment
<p>Neural stem cells (NSCs) were described for the first time more than two decades ago for their ability to differentiate into all neural cell lineages. The isolation of NSCs from adults and embryos was carried out by various laboratories and in different species, from mice to humans. Similarly, no more than two decades ago, cancer stem cells were described. Cancer stem cells, previously identified in hematological malignancies, have now been isolated from several solid tumors (breast, brain, and gastrointestinal compartment). Though the origin of these cells is still unknown, there is a wide consensus about their role in tumor onset, propagation and, in particular, resistance to treatments. Normal and neoplastic neural stem cells share common characteristics, and can thus be considered as two sides of the same coin. This is particularly true in the case of the Zika virus (ZIKV), which has been described as an inhibitor of neural development by specifically targeting NSCs. This understanding prompted us and other groups to evaluate ZIKV action in glioblastoma stem cells (GSCs). The results indicate an oncolytic activity of this virus vs. GSCs, opening potentially new possibilities in glioblastoma treatment.</p>
Zika 2AA_150mMallSymmetries
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Comparative evaluation of select serological assays for Zika virus using blinded reference panels
<p>The aim of this study was to compare assays for detection of immunoglobulin M and/or G (IgM or IgG) from multiple manufacturers. Panels of specimens for testing IgM and IgG assays were built using longitudinal samples collected from blood donors with viral RNA confirmed infections with ZIKV, dengue virus (DENV) and West Nile virus (WNV), respectively. Specimens IgM- or IgG-positive against chikungunya virus (CHIKV), of the genus <em>alphavirus</em> were also included, together with ZIKV-negative samples from endemic (Puerto Rico) and non-endemic (continental USA) regions. Panels were compiled, blinded, and sent to manufacturers for testing. Seven IgM and five IgG assays from four manufacturers were evaluated.</p>
Preliminary results from Zika virus helicase fragment screening
<p>Preliminary results from Zika virus helicase fragment screening</p>
Safety and Immunogenicity of the Live Attenuated Zika Vaccine rZIKV/D4Δ30-713 in Flavivirus-naïve Adults
ClinicalTrials.gov study NCT03611946. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.