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3,241 results for “alcoholic”
Data for 'From Gel to Crystal: Mechanism of HfO2 and ZrO2 Nanocrystal Synthesis in Benzyl Alcohol'
<p>Data of the figures in the publication "<strong>From Gel to Crystal: Mechanism of HfO<sub>2</sub> and ZrO<sub>2</sub> Nanocrystal Synthesis in Benzyl Alcohol</strong>".</p> <p>The <em>.pxp</em> documents contain the experimental data of the figures in the manuscript and they can be opened/edited with the software IGOR Pro 6.3 or higher.</p> <p>Table of contents:</p> <p><strong>Figure 1.</strong> (A) Microwave-assisted solvothermal synthesis of HfO<sub>2</sub> nanocrystals starting from HfCl<sub>4</sub>·2THF in benzyl alcohol. (B) XRD spectrum (black) with a monoclinic reference spectrum (blue, Crystallographic Open Database ID 9013470). (C) Pictures of the upside down microwave tube, stopped at different time points in the reaction to indicate the disappearance of the gel over time. (D) TEM image of the synthesized NCs shows their ellipsoidal shape. The size distribution and a zoom of a single NC are shown in the top and bottom left corner, respectively. (E) The rapid increase in storage modulus <em>G</em>′ and loss modulus <em>G</em>″ over time (average of 3 measurements) indicates the point where the solution turns into a gel. (F) Storage modulus <em>G</em>′ and loss modulus <em>G</em>″ of the gel after repeatedly (three cycles) applying 10% (stress) and 1% (recovery) shear stress (γ) at 25 °C and (G) at 160 °C.</p> <p><strong>Figure 2.</strong> (A) Titration of HfCl<sub>4</sub>·2THF with benzyl alcohol in the presence of TOPO in C<sub>6</sub>D<sub>6</sub>, followed via <sup>31</sup>P NMR. The spectra have a relative <em>x</em>-offset of 1 ppm with respect to each other for clarity. (B) Coordination numbers of chloride and oxygen surrounding the hafnium center, calculated from the EXAFS data. (C) Hf–O distance contraction at increasing temperature. The octahedral of the HfCl<sub>3</sub>OBn·2THF structure is shown for clarity.</p> <p><strong>Figure 3. </strong>(A) <sup>1</sup>H NMR assignment of the resonances in the supernatant between 4.4 and 4.8 ppm. The full width at half-maximum (in Hz) of the benzyl alcohol peak is indicated and decreases with increasing temperature. (B) Equivalents of benzyl alcohol, dibenzyl ether, and benzyl chloride with respect to hafnium (taking into account other side products present) in the reaction supernatant at increasing temperature. The amount of water is calculated based on the amount of dibenzyl ether and benzyl chloride detected.</p> <p><strong>Figure 4. </strong>(A) <em>In situ</em> total scattering data showing <em>G</em>(<em>r</em>) as a function of time. Dashed lines indicate when temperature is increased. Selected PDFs from the intermediate and the final stage of the reaction are plotted. (B) PDF of the precursor structure with major peaks assigned and in comparison to simulated PDFs based on the possible precursor structures. Fit of the PDF data of (C) the intermediate gel, collected after 9 min of reaction at 150 °C, and (D) the final product to m-HfO<sub>2</sub>, collected after 81 min of total reaction time. (E) Refined crystallite size and scale factor as a function of time. (F) TEM image of a sample after 3 min at 220 °C. The size distribution (25 particles) and zoom of a single NC are shown in the top and bottom left corner, respectively.</p> <p><strong>Figure 5. </strong>Isolated particle yield of HfO<sub>2</sub> NC syntheses run for different reaction times. The yield can be significantly improved at only 1 h by adding water postsynthesis. Each reaction is performed in triplicate, and yield is determined gravimetrically.</p>
alcohol by country
<p>Este dataset contiene datos de alcoholismo por pais.</p>
Healthy and Alcoholic liver ASCs data
<p>Filtered VCF-files, metadata, BED-files with callable regions, and RNA-Seq counts of healthy and alcoholic liver ASCs.</p>
Raw data for the article "Enamine Synthesis via Regiocontrolled 6-endo-dig and 5-exo-dig Tethered Carboamination of Propargylic Alcohols"
<p>Raw NMR, IR and MS data for the article "Enamine Synthesis via Regiocontrolled 6-endo-dig and 5-exo-dig Tethered Carboamination of Propargylic Alcohols" published in Angewandte Chemie, DOI: </p> <p>https://doi.org/10.1002/anie.202411383 </p> <p>The number of the folders either correspond to compounds numbers in the article or the name of the folder is self-describing. All details concerning conditions and equipment for measurements can be found in the supporting information of the article. For convenience, the word file version of the supporting information can be found on the top of the raw data folder.</p>
Reductive synthesis of azoxypyridines from nitropyridines using hydroxides in alcoholic media by L. Caruana et al. - Raw NMR data
<p>NMR raw data for the work "Reductive synthesis of azoxypyridines from nitropyridine using hydroxides in alcoholic media"</p>
Assessment of legume starches to determine rheological characteristics relevant to alcohol production
<p>In the production of any alcoholic beverage you must understand the starch present and how to degrade it (via gelatinisation, liquefaction and saccharification) to simple sugars that are usable by yeast. Through using a RVA and a new rheometer method the gelatinisation temperature of a raw materials starch has been identified. This is the point where starch granules have become swollen with water and burst open to release their starch into solution thus making it available for enzymatic breakdown. This temperature point is specific to the raw material being used and is critical in producing a fermentable feedstock. This method can further be used to assess the success of different enzyme additions on starch breakdown; with a decrease in viscosity indicating successful enzymatic breakdown.</p> <p>Samples are milled to produce a fine grist. A fixed amount of the grist is then used to form a slurry with a calculated weight of water and run on a pre-set rheometer programme. The programme consists of an initial rapid stir followed by continuous stirring as temperature is increased, held, then decreased. The rheometer software then produces a chart output of the viscosity over time from which conclusions such as starch gelatinisation temperature, enzyme activity etc can be drawn.</p>
Phenotypic variations of primary metabolites yield during alcoholic fermentation in the Saccharomyces cerevisiae species
<p>Supplementary data including the data set used for the" Phenotypic variations of primary metabolites yield during alcoholic fermentation in the Saccharomyces cerevisiae species" publication.</p> <p> </p> <p>Abstract:</p> <p><em>Saccharomyces cerevisiae</em>, as the workhorse of alcoholic fermentation, is a major actor of winemaking. In this context, this yeast species performs alcoholic fermentation to convert sugars from the grape must into ethanol and CO<sub>2</sub> with an outstanding efficiency: it reaches on average 92% of the maximum theoretical yield of conversion. Primary metabolites produced during fermentation stand for a great importance in wine where they significantly impact wine characteristics. Ethanol indeed does, but others too, which are found in lower concentrations: glycerol, succinate, acetate, ⍺-ketoglutarate… Their production, which can be characterised by a yield according to the amount of sugars consumed, is known to differ from one strain to another. <em>S. cerevisiae</em> is known for its great genetic diversity and plasticity that is directly related to its living environment, natural or technological and therefore to domestication. This leads to a great phenotypic diversity of metabolites production. However, the range of metabolic diversity is variable and depends on the pathway considered. In the aim to improve wine quality, the selection, development and use of strains with dedicated metabolites production without genetic modifications can rely on the natural diversity that already exists. Here we detail a screening that aims to assess this diversity of primary metabolites production in a set of 51 <em>S. cerevisiae</em> strains from various genetic backgrounds (wine, flor, rum, West African, sake…). To approach winemaking conditions, we used a synthetic grape must as fermentation medium and measured by HPLC five main metabolites. Results obtained pointed out great yield differences between strains and that variability is dependent on the metabolite considered. Ethanol appears as the one with the smallest variation among our set of strains, despite it’s by far the most produced. A clear negative correlation between ethanol and glycerol yields has been observed, confirming glycerol synthesis as a good lever to impact ethanol yield. Genetic groups have been identified as linked to high production of specific metabolites, like succinate for rum strains or alpha-ketoglutarate for wine strains. This study thus helps to define the phenotypic diversity of <em>S. cerevisiae</em> in a wine-like context and supports the use of ways of development of new strains exploiting natural diversity. Finally, it provides a detailed data set usable to study diversity of primary metabolites production, including common commercial wine strains.</p>
Syngas conversion into higher alcohols via bio-based CuCo-wood carbon catalyst
<p>yngas conversion to higher alcohols (HAS) is a promising way of converting coal or biomass into liquid fuels. However, the high cost, low activity, and selectivity of C2+OH hinder the commercialization of this process. Herein, we investigate the stability and selectivity of low-cost Cu/Co carbon wood (CW) catalysts. We noticed that the nucleation of Cu/Co nanoparticles was influenced by different water–1,2-propylene glycol ratios in the solution, where two sizes of nanoparticles were observed. The optimal catalyst displayed a high CO conversion of 74.8% and selectivity of 58.7% for C2+OH, which is mainly linear primary alcohol. Besides the best-performing catalyst was tested under industrial conditions, where high stability and selectivity were maintained for up to 350 h. In addition, selectivity was analyzed using Density functional theory (DFT) insights to identify the binding strength of CO, which can further react to form CH3OH. As well as the route of CHx and CO coupling which eventually produces C2H5OH. High performance with a computational understanding of the Cu/Co-carbon wood catalyst will open new possibilities for developing selective materials toward the production of higher alcohols. </p>
Comparación de tecnologías en la obtención de alcoholes grasos naturales
<p>Por su carácter anfifílico, los alcoholes grasos (FOL) exhiben actividades tensoactivas, lo que permite su utilización en emulsiones y microemulsiones en la industria como densificadores. Además, son usados en la producción de surfactantes iónicos y no iónicos, en la producción de éter sulfatos de alcoholes grasos, alcoholes poliglico éteres y alcoholes grasos etoxilados, teniendo estos últimos surfactantes bajo grado de formación de espuma. Estos FOL, por sus propiedades activas superficiales, son ampliamente utilizados en la industria de detergentes y agentes de limpieza y cosmética, por lo que su importancia comercial va en aumento. Diferentes compañías han desarrollado procesos catalíticos para obtener FOL que involucran elevadas temperaturas (473-573 K), altas presiones de H2 (4-30 MPa) y catalizadores basados en Cr, que genera serios perjuicios ambientales. Sin embargo, el enfoque actual se centra en buscar condiciones de reacción más suaves con materiales menos nocivos. Entre estas estrategias se encuentran el empleo de catalizadores basados en metales nobles, sustitución de H2 gaseoso externo por H2 generado in situ en reacciones paralelas (redox, hidrólisis y alcohólisis) a la obtención de FOL, y el empleo de materiales basados en hidruros metálicos para sustituir el H2 gaseoso. En este trabajo se realiza una comparación entre resultados propios en la obtención de diferentes FOL a partir de metil ésteres y ácidos grasos con resultados obtenidos en la literatura empleando métodos convencionales y alternativos. En reacciones de hidrogenación de ácido oleico, a 2 MPa de presión y 563 K fue posible obtener un 82% de rendimiento al alcohol oleico (ALO) empleando catalizadores bimetálicos (1%)Rh-(4%)Sn-B en Al2O3 y TiO2 en un reactor discontinuo. Estas tecnologías pueden ser escaladas a la obtención de FOL a partir de biodiesel con alto contenido de ácido oleico, como el derivado de los aceites de soya, girasol o maíz, e incluso aumentar la cadena de valor a los aceites usados, reduciendo así la disposición de estos residuos sobre las vertientes. En algunos estudios preliminares, se han alcanzado buenos rendimientos a ALO con catalizadores RhSn-B/Al2O3 con biodiesel de soya cercanos al 50%, con buena actividad y selectividad por lo menos para 5 ciclos de reutilización. Adicionalmente, el escalamiento a un sistema de flujo continuo para la hidrogenación selectiva de biodiesel está siendo desarrollada para este tipo de catalizadores. Por otra parte, la obtención selectiva de FOL puede darse empleando hidruros metálicos con solventes adecuados. En este sentido, en reacciones de reducción empleando NaBH4 y metanol como co-reactivos fue posible reducir metil laurato, metil miristato y metil oleato a alcohol láurico, alcohol mirístico y alcohol oleico con rendimientos del 93, 90,8 y 34,5%, respectivamente. Una tecnología alternativa muy interesante es producir FOL con H2 generado in situ, valiéndose de la reacción redox entre el Fe y el agua para generar H2. De esta forma se logra sustituir el H2 suministrado externamente y se eliminan los riesgos asociados al almacenamiento y el transporte del mismo. Como resultado, se logró un rendimiento del 61% a alcohol láurico a partir de metil laurato con un catalizador Ru-Sn-Mo/C a 543 K. Si bien este sistema es novedoso, presenta desventajas como problemas operacionales, tiempos prolongados de pretratamiento, rendimientos bajos y altas cargas de Ru, haciendo el proceso económicamente ineficiente.</p>
Association of fat-to-muscle ratio with non-alcoholic fatty liver disease: a single-centre retrospective study
<p><strong>Objectives</strong>: Sarcopenia is a known risk factor for non-alcoholic fatty liver disease (NAFLD). Studies evaluating the association between the fat-to-muscle ratio (FMR) and NAFLD are limited. Therefore, the aim of our study was to investigate the association between FMR and NAFLD.</p> <p><strong>Design:</strong> A retrospective study was conducted on the individuals who underwent health examination in Wuhan Union Hospital between January 2020 and November 2021. Clinical data were collected from electronic medical records.</p> <p><strong>Setting:</strong> Our study was conducted in a hospital in China.</p> <p><strong>Participants:</strong> A total of 1,592 participants aged ≥40 years who underwent body composition analysis and liver ultrasonography were retrospectively reviewed.</p> <p><strong>Primary outcome measures:</strong> Liver ultrasonography was used to assess liver steatosis, and the Fibrosis-4 Index (FIB-4) was used to calculate the risk scores for liver fibrosis. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk prediction model was used to calculate ASCVD risk scores.</p> <p><strong>Results:</strong> The FMR was significantly higher in individuals with NAFLD than in those without NAFLD (P<0.001). The prevalence of NAFLD gradually increased from FMR tertile 1 (reference) to tertile 2 (OR=1.49, 95% CI: 1.13–1.97) and tertile 3 (OR=2.85, 95% CI: 2.08–3.90). In addition, patients with NAFLD in FMR tertile 3 had a significantly higher risk of liver fibrosis (OR=4.48, 95% CI: 2.12–9.50) and ASCVD (OR=4.63, 95% CI: 2.62–8.19) than those in FMR tertile 1 after adjustment for multiple confounders.</p> <p><strong>Conclusion:</strong> In this study, we found a significant association between FMR and NAFLD. A higher FMR indicates a higher risk of NAFLD in the study population and a higher risk of liver fibrosis and ASCVD in NAFLD patients.</p>
Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis.
ClinicalTrials.gov study NCT02970942. IPD Sharing: YES. Countries: 17. Publications: 7.
Efficacy of Nalmefene in Patients With Alcohol Dependence
ClinicalTrials.gov study NCT00812461. IPD Sharing: Not stated. Countries: 7. Publications: 4.
Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Hispanics With Diabetes Mellitus Type 2 (T2DM) and Role of Treatment
ClinicalTrials.gov study NCT01002547. IPD Sharing: NO. Countries: 1. Publications: 1.
Aripiprazole Effects on Alcohol Drinking and Craving
ClinicalTrials.gov study NCT01292057. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Addressing Heavy Alcohol Use Consumption With Kudzu
ClinicalTrials.gov study NCT03709043. IPD Sharing: NO. Countries: 1. Publications: 0.
A Phase ll Study of IMM-124E for Patients With Non-alcoholic Steatohepatitis
ClinicalTrials.gov study NCT02316717. IPD Sharing: Not stated. Countries: 3. Publications: 2.
Varenicline for Alcohol Dependence
ClinicalTrials.gov study NCT01146613. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Transcranial Magnetic Stimulation for the Treatment of Veterans With Alcohol Use Disorders
ClinicalTrials.gov study NCT03191266. IPD Sharing: YES. Countries: 1. Publications: 1.
Text-based Alcohol Prevention for First Year College Students
ClinicalTrials.gov study NCT03864237. IPD Sharing: YES. Countries: 1. Publications: 1.
Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis
ClinicalTrials.gov study NCT01809132. IPD Sharing: Not stated. Countries: 1. Publications: 4.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.