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Fig. 7. Hypothetical biosynthetic pathway for undescribed compounds 1–3 in Phlegcarines A-C, three Lycopodium alkaloids from Phlegmariurus carinatus (Desv. ex Poir.) Ching

Fig. 7. Hypothetical biosynthetic pathway for undescribed compounds 1–3 and some isolated Lycopodium alkaloids.

Fig. 2 in Phlegcarines A-C, three Lycopodium alkaloids from Phlegmariurus carinatus (Desv. ex Poir.) Ching

Fig. 2. Key COSY, TOCSY (black bold lines) and HMBC (red arrows) correlations of compounds 1–3. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Fig. 4 in Phlegcarines A-C, three Lycopodium alkaloids from Phlegmariurus carinatus (Desv. ex Poir.) Ching

Fig. 4. (a)–(c) Experimental and calculated ECD spectra of 1 3 and (d) compared ECD spectra between 3 and 7.

Fig. 3 in Phlegcarines A-C, three Lycopodium alkaloids from Phlegmariurus carinatus (Desv. ex Poir.) Ching

Fig. 3. Key ROESY (blue arrows) and NOESY (purple arrows) correlations of compounds 1–3. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

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Fig. 4 in The anti-TMV potency of the tobacco-derived fungus Aspergillus versicolor and its active alkaloids, as anti-TMV activity inhibitors

Fig. 4. Docking poses (left) and interactions (right) of compound 10 (yellow) at the binding site of TMV (blue, PDB code 2OM3). The ligand with TMV A chain amino GLY-135 (1.92 Å) form three hydrogen bonds (green dotted line), Hydrogen bonding distance had been hidden for clarity. The binding energy of compound 10 for between ligands and TMV. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

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Fig. 2. The key 1H–1H in The anti-TMV potency of the tobacco-derived fungus Aspergillus versicolor and its active alkaloids, as anti-TMV activity inhibitors

Fig. 2. The key 1H–1H COSY (bold lines), HMBC (solid arrows), and ROESY (dashed arrows) correlations of compounds 1–5.

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Fig. 3 in The anti-TMV potency of the tobacco-derived fungus Aspergillus versicolor and its active alkaloids, as anti-TMV activity inhibitors

Fig. 3. Docking poses (left) and interactions (right) of compound 1 (yellow) at the binding site of TMV (blue, PDB code 2OM3). The ligand with TMV. A chain amino ASN-73 (2.81 Å) and TYR-139 (3.04 Å) form four hydrogen bonds (green dotted line), Hydrogen bonding distance had been hidden for clarity. The binding energy of strong affinity between ligands and TMV. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article

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Fig. 5. a in Alkaloids from Picrasma quassioides: An overview of their NMR data, biosynthetic pathways and pharmacological effects

Fig. 5. a The possible biosynthetic pathway of bis-β-carboline alkaloids. Fig. 5b The possible biosynthetic pathway of bis-β-carboline alkaloids.

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Fig. 2 in Antiproliferative Amaryllidaceae alkaloids from the bulbs of Hymenocallis littoralis (Jacq.) Salisb

Fig. 2. (A) Selected 2D NMR correlations (COSY, NOESY and HMBC) of Compounds 2, 7 and 9–11. (B) NOESY correlations of Compounds 1 and 7 in the 3D molecular models. (C) Experimental and calculated ECD spectra of Compounds 1, 2, 5 and 7–9.

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Fig. 3 in Antiproliferative Amaryllidaceae alkaloids from the bulbs of Hymenocallis littoralis (Jacq.) Salisb

Fig. 3. Antitumour mechanism of Compounds 10, 13 and 14. (A) Colony formation assays on the proliferation of HepG2 and HeLa cells. (B) Inhibitory effect on cell migration capabilities through colony formation assay. (C) Apoptosis-induced HepG2 and HeLa cells and changes in cell-nuclei morphology. (D) The expression of apoptosis-related proteins analysed by Western blot. (E) Effect of the indicated concentrations of Compounds 10, 13 and 14 on apoptosis in HepG2/HeLa cells. *p <0.1, ****p <0.0001 compared with control.

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Fig. 10 in Benzobicyclic ketones, cycloheptenone oxide derivatives, guaiane-type sesquiterpenes, and alkaloids isolated from Taraxacum mongolicum Hand.-Mazz.

Fig. 10. NO production inhibited by compounds 3 and 11 (A) and IL-6 mRNA levels altered by compounds 3 and 11 (B) after RAW 264.7 macrophages were induced by 100 ng/mL LPS (DMSO was the blank control). The data are presented as the means ± SD (n = 3). Comparisons were made between the DMSO and LPS groups (##p <0.01) and between the LPS and different compound groups (*p <0.05; **p <0.01).

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Fig. 6 in Cirrhosinones A-H, 24-hydroxy cevanine-type alkaloids from Fritillaria cirrhosa

Fig. 6. The inhibitory effect of compounds 1–9 on the production of NO in LPS-induced BV-2 cells (n = 3). Dexamethasone was used as positive control.

Fig. 4 in Corybungines A K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity

Fig. 4. (A) Experimental and calculated ECD spectra of compound 1 in MeOH. (B) Experimental ECD spectra of compounds 6–11 in MeOH.

Fig. 4. Amino acid sequences alignment between TCS1 and candidate N in Discovery and Biochemical Characterization of N-methyltransferase Genes Involved in Purine Alkaloid Biosynthetic Pathway of Camellia gymnogyna Hung T.Chang (Theaceae) from Dayao Mountain

Fig. 4. Amino acid sequences alignment between TCS1 and candidate N-methyltransferase genes (GCS1, GCS2, and GCS3).

Fig. 2 in Discovery and Biochemical Characterization of N-methyltransferase Genes Involved in Purine Alkaloid Biosynthetic Pathway of Camellia gymnogyna Hung T.Chang (Theaceae) from Dayao Mountain

Fig. 2. Purine alkaloid content in different leaf positions of C. gymnogyna and other tea plants. Bud, 1st, 2nd, 3rd, 4th, and 5th represent the apical bud, first leaf, second leaf, third leaf, and fourth leaf, respectively. Total purine alkaloid concentration is the sum of Tb, Cf, and Tc. Asterisk indicates not detected. A lack of sufficient Kucha bud samples prohibited the analysis of that component. Data represent the mean value ± SD of independent experiments performed in triplicate. Data with the same letter and numeric above SD bar in each column are not significantly different from each other at P ≦ 0.05. Data with alphabet are significantly different from the data with numeric above SD bar.

Fig. 6. N in Discovery and Biochemical Characterization of N-methyltransferase Genes Involved in Purine Alkaloid Biosynthetic Pathway of Camellia gymnogyna Hung T.Chang (Theaceae) from Dayao Mountain

Fig. 6. N-methyltransferase gene expression patterns in different leaf positions of C. gymnogyna and other tea plants. Bud, 1st, 2nd, 3rd, 4th, and 5th represent the apical bud, first leaf, second leaf, third leaf, and fourth leaf, respectively.

Fig. 5 in Discovery and Biochemical Characterization of N-methyltransferase Genes Involved in Purine Alkaloid Biosynthetic Pathway of Camellia gymnogyna Hung T.Chang (Theaceae) from Dayao Mountain

Fig. 5. Phylogenetic tree of N-methyltransferase amino acid sequences. Substrates of the enzymes are indicated in parentheses. The following amino acid sequences were subjected to sequence alignment: TCS1, AB031280; CKCS, MN163829; TCS1d, KT215399; TCS1f, KT215398; TCS1e, KT215397; CkTcS, MN163831; CkTbS, MN163830; ICS1, AB056108; PCS1, AB207817; ICS2, AB207816; PCS2, AB207818; TCS2, AB031281; CkCS1, AB362884; CjCS1, AB297451; CgCS1, AB362882; CgCS2, AB362883; ClCS1, AB362885; CsSAMT, MG459470. Abbreviations of substrates are as follows: 7-mX, 7-methylxanthine; Tb, theobromine; Tc, theacrine; XR, xanthosine; CsSAMT as a outgroup.

Fig. 1 in Discovery and Biochemical Characterization of N-methyltransferase Genes Involved in Purine Alkaloid Biosynthetic Pathway of Camellia gymnogyna Hung T.Chang (Theaceae) from Dayao Mountain

Fig. 1. Main metabolic pathway for the biosynthesis and biodegradation of Cf. SAM = S-adenosyl- L -methionine, SAH = S-adenosyl- L -homo-cysteine. (b). Numbers (I, II, III, and IV) in (b) correspond to the reactions I, II, III, and IV in (a), respectively. TCS1 and CkCS have broad substrate specificities and catalyze the conversion of 7-mX to Cf via Tb [reactions II and III in (a)].

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Fig. 5 in Dimeric Erythrina alkaloids as well as their key units from Erythrina variegata

Fig. 5. The dose-dependent response of erythrivarine T in HEI–OC–1 cells treated with neomycin (20 mM). Cell survival (mean ± SD, n = 3) after treatment with various concentrations of compounds and/or neomycin (Neo). The significance was determined by Student's t-test (*p <0.05, **p <0.01, ***p <0.001 vs. neomycin-only group).

Fig. 3 in Discovery and Biochemical Characterization of N-methyltransferase Genes Involved in Purine Alkaloid Biosynthetic Pathway of Camellia gymnogyna Hung T.Chang (Theaceae) from Dayao Mountain

Fig. 3. Gene annotation. (a) Venn diagram; (b) The results of volcano plots of differential genes between the experimental groups; (c) GO annotation of DEGs; (d) The top 20 KEGG pathways of DEGs.