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1,042 results for “astrocyte”
Data from: Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii
Lysine acetylation is a reversible post-translational modification (PTM) that has been detected on thousands of proteins in nearly all cellular compartments. The role of this widespread PTM has yet to be fully elucidated, but can impact protein localization, interactions, activity, and stability. Here we present the first proteome-wide survey of lysine acetylation in cortical astrocytes, a subtype of glia that is a component of the blood-brain barrier and a key regulator of neuronal function and plasticity. We identified 529 lysine acetylation sites across 304 proteins found in multiple cellular compartments that largely function in RNA processing/transcription, metabolism, chromatin biology, and translation. Two hundred and seventy-seven of the acetylated lysines we identified on 186 proteins have not been reported previously in any other cell type. We also mapped an acetylome of astrocytes infected with the brain parasite, Toxoplasma gondii. It has been shown that infection with T. gondii modulates host cell gene expression, including several lysine acetyltransferase (KAT) and deacetylase (KDAC) genes, suggesting that the host acetylome may also be altered during infection. In the T. gondii-infected astrocytes, we identified 34 proteins exhibiting a level of acetylation >2-fold and 24 with a level of acetylation <2-fold relative to uninfected astrocytes. Our study documents the first acetylome map for cortical astrocytes, uncovers novel lysine acetylation sites, and demonstrates that T. gondii infection produces an altered acetylome.
Effect of 3D Synthetic Microscaffold Nichoid on the Morphology of Cultured Hippocampal Neurons and Astrocytes
<p>The dataset contains the raw data and images of the paper.</p>
Divergent consequences of Extracellular tau on the mitochondrial function of astrocytes
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Tabular datasets for for Morrone Parfitt, G., Coccia, E., Goldman, C. et al. Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model. Nat Commun 15, 447 (2024). https://doi.org/10.1038/s41467-024-44732-2
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Astrocyte video S1 and Neuron Video S2
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blue astrocyte
SciDraw upload
Astrocytic Expression of Yes-Associated Protein (YAP) Regu-lates Retinal Neovascularization in a Mouse Model of Oxy-gen-Induced Retinopathy
<p>Original images used for each figure.</p>
Study of Multiple Doses and Regimens of XL184 (Cabozantinib) in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse
ClinicalTrials.gov study NCT01068782. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Data from: Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii
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Data from: Simulated blast overpressure induces specific astrocyte injury in an ex vivo brain slice model
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Mouse ES-derived motor neurons (ES-MN) exposed to SOD1 mutant mouse astrocyte conditioned media
GEO Series GSE49023. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Neuron-Derived Estrogen is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain
GEO Series GSE143836. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Diverse gene expression of diencephalon astrocytes reveals proliferation regulated by Smad4 - scRNA-seq II
GEO Series GSE176456. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1
GEO Series GSE208742. Mus musculus. 64 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other.
Divergent transcriptional regulation of astrocyte reactivity across disorders [TR_ATAC_SCI]
GEO Series GSE199481. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch
GEO Series GSE76412. Mus musculus; Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Single cell deletion of the transcription factors Sox9 and Trps1 reveals novel functions in adult cortical astrocytes [RNA-seq]
GEO Series GSE279677. Mus musculus. 289 samples. Type: Expression profiling by high throughput sequencing.
Layer-specific molecular expression in neocortical astrocytes
GEO Series GSE111916. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Maternal high-fat diet alters the characteristics of astrocytes and worsens the outcome of stroke in rat offspring, which improves after FGF21 administration
GEO Series GSE189679. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial Dysfunction and Increased Reactive Oxygen Species Production in MECP2 Mutant Astrocytes and their Impact on Neurons
GEO Series GSE226975. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.