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96 results for “biomaterials”
Data from: Behavioral and biomaterial coevolution in spider orb webs
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DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation
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Data from: Porous poly-l-lactide-co-ε-caprolactone scaffold: a novel biomaterial for vaginal tissue engineering
The surgical reconstruction of functional neovagina is challenging and susceptible to complications. Therefore, developing tissue engineering based treatment methods for vaginal defects is important. Our aim was to develop and test a novel supercritical carbon dioxide foamed poly-l-lactide-co-ε-caprolactone (scPLCL) scaffold for vaginal reconstruction. The scaffolds were manufactured and characterized for porosity (65±4%), pore size (350±150µm) and elastic modulus (2.8±0.4MPa). Vaginal epithelial (EC) and stromal cells (SC) were isolated, expanded, and characterized with flow cytometry. Finally, cells were cultured with scPLCL scaffolds in separate and/or co-cultures. Their attachment, viability, proliferation and phenotype were analyzed. Both cell types strongly expressed cell surface markers CD44, CD73, and CD166. Strong expression of CD326 was detected with ECs and CD90 and CD105 with SCs. Both ECs and SCs attached and maintained viability on scPLCL. Further, scPLCL supported the proliferation of especially ECs, which also maintained epithelial phenotype (cytokeratin expression) during 14d assessment period. Interestingly, ECs expressed uroplakin (UP) Ia, UPIb, and UPIII markers, further, UPIa and UPIII expression was significantly higher on ECs cultured on scPLCL than on cell culture plastic. In conclusion, the scPLCL is potential scaffold for vaginal tissue engineering and the results of this study further illustrates the excellent biocompatibility of PLCL.
Supplementary Videos for dissertation: Tunable magnetic microparticles and hydrogel biomaterials for biomedical imaging and tissue engineering applications
<p>This work contains supplementary videos of cell migration in hydrogels for the chapter 4 of the dissertation.</p>
Advanced in vitro hemocompatibility assessment of biomaterials using a new flow incubation system
<p>We present a new setup that enables standardized whole blood incubation of biomedical materials under flow. A blood volume of 2 ml is recirculated over test surfaces in a custom-made parallel plate incubation system to determine the activation of hemostasis and inflammation. Controlled physiological shear rates between 125 s<sup>-1</sup> and 1,250 s<sup>-1</sup> and minimized contact to air are combined with a natural-like pumping process. A unique feature of this setup allows tracing adhesion of blood cells to test surfaces microscopically <em>in situ</em>. Validation testing was performed in comparison to previously applied whole blood incubation methodologies.</p>
Long-term Outcome Evaluation of Patients Undergoing Autologous Chondrocyte Transplantation Delivered on Biomaterial
ClinicalTrials.gov study NCT06238947. IPD Sharing: Not stated. Countries: 0. Publications: 10.
Entire Papilla Preservation Technique With and Without Biomaterials in the Treatment of Isolated Intrabony Defects
ClinicalTrials.gov study NCT03923465. IPD Sharing: NO. Countries: 0. Publications: 3.
Clinical and Radiographic Assessments of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate as Pulpotomy Biomaterials in Immature Mandibular First Permanent Molars
ClinicalTrials.gov study NCT03166748. IPD Sharing: NO. Countries: 0. Publications: 33.
Comparative Results of Six Biomaterials Used in Two-stage Maxillary Sinus
ClinicalTrials.gov study NCT03496688. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Using Different Biomaterials to Preserve Bone After Tooth Extraction
ClinicalTrials.gov study NCT07394738. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Porous poly-l-lactide-co-ε-caprolactone scaffold: a novel biomaterial for vaginal tissue engineering
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Engineered biomaterial immunological niches as a surrogate for diseased tissue in chronic progressive EAE
GEO Series GSE287968. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Infusible Extracellular Matrix Biomaterial Enhances and Expedites Cell-Specific Pro-Repair Following Acute Myocardial Infarction
GEO Series GSE299772. Rattus norvegicus. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
A single-cell atlas of the microenvironment of implanted biomaterials and computational analysis of the transcriptional signalling networks [bulk RNA-seq]
GEO Series GSE175888. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
A single-cell atlas of the microenvironment of implanted biomaterials and computational analysis of the transcriptional signalling networks
GEO Series GSE175890. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
Discerning Biomaterials-driven Transcriptome Dynamics to Induce Mesenchymal Stem Cell Differentiation
GEO Series GSE193172. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
A single-cell atlas of the microenvironment of implanted biomaterials and computational analysis of the transcriptional signalling networks [single-cell RNA-seq]
GEO Series GSE175889. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Clinical and Radiographic Assessment of Platelet Rich Fibrin and Mineral Trioxide Aggregate as Pulp Capping Biomaterials
ClinicalTrials.gov study NCT04488679. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Comparative Analysis of Biomaterials for Retrograde Filling in Apical Surgery.
ClinicalTrials.gov study NCT07246512. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Evaluation of the Effect of Different Biomaterials on Palatal Wound Healing.
ClinicalTrials.gov study NCT07072182. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.