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3,134 results for “bone marrow”
Ki-67 and Bcl-2 data by flow cytometry in non-malignant bone marrow aspirates and patients with myeloid malignancies
<p>This Data in Brief article displays a flow cytometric assay that was used for the acquisition and analyses of proliferative and anti-apoptotic activity in hematopoietic cells. This dataset includes analyses of the Ki-67 positive fraction (Ki-67 proliferation index) and Bcl-2 positive fraction (Bcl-2 anti-apoptotic index) of the different myeloid bone marrow (BM) cell populations in non-malignant BM, and in BM disorders, i.e. myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The present dataset comprises 1) the percentage of the CD34 positive blast cells, erythroid cells, myeloid cells and monocytic cells, and 2) the determined Ki-67 positive fraction and Bcl-2 positive fraction of these cell populations in tabular form. This allows the comparison and reproduction of the data when these analyses are repeated in a different setting. Because gating the Ki-67 positive and Bcl-2 positive cells is a critical step in this assay, different gating approaches were compared to determine the most sensitive and specific approach. BM cells from aspirates of 50 non-malignant, 25 MDS and 27 AML cases were stained with 7 different antibody panels and subjected to flow cytometry for determination of the Ki-67 positive cells and Bcl-2 positive cells of the different myeloid cell populations. The Ki-67 or Bcl-2 positive cells were then divided by the total number of cells of the respective cell population to generate the Ki-67 positive fraction (Ki-67 proliferation index) or the Bcl-2 positive fraction (Bcl-2 anti-apoptotic index). The presented data may facilitate the establishment and standardization of flow cytometric analyses of the Ki-67 proliferation index and Bcl-2 anti-apoptotic index of the different myeloid cell populations in non-malignant BM as well as MDS and AML patients in other laboratories. Directions for proper gating of the Ki-67 positive and Bcl-2 positive fraction are crucial for achieving standardization among different laboratories. In addition, the data and the presented assay allows application of Ki-67 and Bcl-2 in a research and clinical setting and this approach can serve as the basis for optimization of the gating strategy and subsequent investigation of other cell biological processes besides proliferation and anti-apoptosis. These data can also promote future research into the role of these parameters in diagnosis of myeloid malignancies, prognosis of myeloid malignancies and therapeutic resistance against anti-cancer therapies in these malignancies. As specific populations were identified based on cell biological characteristics, these data can be useful for evaluating gating algorithms in flow cytometry in general by confirming the outcome (e.g. MDS or AML diagnosis) with the respective proliferation and anti-apoptotic profile of these malignancies. The Ki-67 proliferation index and Bcl-2 anti-apoptotic index may potentially be used for classification of MDS and AML based on supervised machine learning algorithms, while unsupervised machine learning can be deployed at the level of single cells to potentially distinguish non-malignant from malignant cells in the identification of minimal residual disease. Therefore, the present dataset may be of interest for internist-hematologists, immunologists with affinity for hemato-oncology, clinical chemists with sub-specialization of hematology and researchers in the field of hemato-oncology.</p>
3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Primary Refractory Neuroblastoma in Bone Marrow
ClinicalTrials.gov study NCT01183897. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI)
ClinicalTrials.gov study NCT01049919. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Peripheral Blood Stem Cell Transplant vs Bone Marrow Transplant in Individuals With Hematologic Cancers (BMT CTN 0201)
ClinicalTrials.gov study NCT00075816. IPD Sharing: YES. Countries: 2. Publications: 8.
A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3)
ClinicalTrials.gov study NCT03112603. IPD Sharing: NO. Countries: 31. Publications: 5.
A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant
ClinicalTrials.gov study NCT04872595. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety and Efficacy Study of Autologous Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT01363401. IPD Sharing: NO. Countries: 1. Publications: 5.
Stem Cell Transplantation and T-Cell Add-Back to Treat Bone Marrow Malignancies
ClinicalTrials.gov study NCT00079391. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Does Trans-Cutaneous Electrical Nerve Stimulation (TENS) Alleviate The Pain Experienced During Bone Marrow Sampling?
ClinicalTrials.gov study NCT02005354. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507)
ClinicalTrials.gov study NCT03263559. IPD Sharing: YES. Countries: 1. Publications: 3.
Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis
ClinicalTrials.gov study NCT03289416. IPD Sharing: NO. Countries: 1. Publications: 16.
Decitabine and Total-Body Irradiation Followed By Donor Bone Marrow Transplant and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
ClinicalTrials.gov study NCT01707004. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluating the Safety and Effectiveness of Bone Marrow Transplants in Children With Sickle Cell Disease (BMT CTN 0601)
ClinicalTrials.gov study NCT00745420. IPD Sharing: YES. Countries: 1. Publications: 5.
Early Treatment of Acute Graft Versus Host Disease With Bone Marrow-Derived Mesenchymal Stem Cells and Corticosteroids
ClinicalTrials.gov study NCT02379442. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy
ClinicalTrials.gov study NCT00303719. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder
ClinicalTrials.gov study NCT00755040. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients
ClinicalTrials.gov study NCT02924324. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Danazol for Genetic Bone Marrow and Lung Disorders
ClinicalTrials.gov study NCT01441037. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
ClinicalTrials.gov study NCT01098487. IPD Sharing: Not stated. Countries: 11. Publications: 1.
Zoledronate in Treating Bone Marrow Micrometastases in Women With Stage I, Stage II, or Stage III Breast Cancer
ClinicalTrials.gov study NCT00295867. IPD Sharing: NO. Countries: 1. Publications: 1.
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OpenNeuro
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