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674
datasets available to search
ShareScore release 0.9.0
Dataset results
674 results for “brain disease”
Trial Comparing Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Parkinson's Disease
ClinicalTrials.gov study NCT02401308. IPD Sharing: NO. Countries: 1. Publications: 8.
Musical Engagement of Brain LObes in Alzheimer's Disease Patients StudY
ClinicalTrials.gov study NCT05309369. IPD Sharing: YES. Countries: 1. Publications: 1.
DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease
ClinicalTrials.gov study NCT04420598. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Cholinergic Deep Brain Stimulation for Alzheimer's Disease
ClinicalTrials.gov study NCT05882344. IPD Sharing: YES. Countries: 1. Publications: 7.
Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease
ClinicalTrials.gov study NCT01389024. IPD Sharing: NO. Countries: 1. Publications: 4.
A Study to Evaluate Sigma-1 and Dopamine-2 Receptor Occupancy by Pridopidine in the Human Brain of Healthy Volunteers and in Patients With Huntington's Disease
ClinicalTrials.gov study NCT03019289. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Proof of Concept of an Anaplerotic Study Using Brain Phosphorus Magnetic Resonance Spectroscopy in Huntington Disease
ClinicalTrials.gov study NCT01882062. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Brain for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Und
ClinicalTrials.gov study NCT06683378. IPD Sharing: YES. Countries: 1. Publications: 3.
HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal Disease
ClinicalTrials.gov study NCT05865990. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Non-invasive Stimulation of Brain Networks and Cognition in Alzheimer's Disease and Frontotemporal Dementia
ClinicalTrials.gov study NCT03422250. IPD Sharing: NO. Countries: 1. Publications: 2.
Efficacy and Safety Study to Evaluate Gadavist (Gadobutrol) as Contrast Agent in Magnetic Resonance Imaging (MRI) of Brain or Spine Diseases in Chinese Patients
ClinicalTrials.gov study NCT00395460. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exercise and Brain in Coronary Heart Disease
ClinicalTrials.gov study NCT06214624. IPD Sharing: YES. Countries: 1. Publications: 2.
Data for: Deep brain stimulation in early-stage Parkinson disease
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Data from: Movement-responsive deep brain stimulation for Parkinson’s Disease using a remotely optimized neural decoder
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Gut dysbiosis and brain microhemorrhages in young vs aged mice with chronic kidney disease
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Data from: Structural and functional brain connectome in motor neuron diseases: a multicenter MRI study
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Data from: Sleep, inflammation, and cognitive behavior of aged wild-type mice subjected to diffuse brain injury and aged 3xTg-AD mice as a model of Alzheimer’s disease
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Supplementary Data to: Mediterranean diet, Alzheimer's disease biomarkers and brain atrophy in old age
<p><b>Objective:</b> To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and <i>in vivo</i> biomarkers for Alzheimer's disease (AD), we analyzed cross-sectional data from the German Longitudinal Cognitive Impairment and Dementia Study</p> <p><b>Method:</b> The sample (n=512, mean age: 69.5±5<span>.9 years) </span><span><span>included 169 cognitively normal participants and subjects at higher AD risk (53 AD relatives, 209 SCD and 81 MCI).</span></span><span> We </span>defined MeDi adherence based on the Food Frequency Questionnaire. Brain volume outcomes were generated via voxel-based morphometry on T1-MRI and cognitive performance with an extensive neuropsychological battery. AD-related biomarkers (Aβ42/40 ratio, pTau181) in cerebrospinal fluid were assessed in n=226 individuals. We analyzed the associations between MeDi and the outcomes with linear regression models controlling for several covariates. Additionally, we applied hypothesis-driven mediation and moderation analysis. </p> <p><b>Results:</b> Higher MeDi adherence related to larger mediotemporal gray matter volume (p<0.05 FWE corrected), better memory (β±SE = 0.03 ± 0.02; p=0.038), and less amyloid (Aβ42/40 ratio, β±SE = 0.003 ± 0.001; p=0.008) and pTau181 pathology (β±SE = -1.96±0.68; p=0.004). Results were consistent correcting for ApoE- ε4 status. Mediotemporal volume mediated the association between MeDi and memory (40% indirect mediation). Finally, MeDi favorably moderated the associations between Aβ42/40 ratio, pTau181 and mediotemporal atrophy. </p> <p><b>Conclusion:</b> Our findings corroborate the view of MeDi as a protective factor against memory decline and mediotemporal atrophy. Importantly, they suggest that these associations might be explained by a decrease of amyloidosis and tau-pathology. Longitudinal and dietary intervention studies should further examine this conjecture and its treatment implications.</p>
Deep Brain Stimulation in Parkinson's Disease – Current State, Future Prospects and the role of Artificial Intelligence
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Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder: Untargeted Metabolomics and Lipidomics Data Deposition
<p>Raw data files used for untargeted metabolomics and lipidomics in the manuscript "Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder".</p> <p>The PDF document <strong>(Data_Deposition_Naming_Info.pdf)</strong> contains information on the file naming system.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.