Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
190
datasets available to search
ShareScore release 0.9.0
Dataset results
190 results for “brain metabolism”
Data from: Effects of chronic consumption of sugar-enriched diets on brain metabolism and insulin sensitivity in adult Yucatan Minipigs
Excessive sugar intake might increase the risk to develop eating disorders via an altered reward circuitry, but it remains unknown whether different sugar sources induce different neural effects and whether these effects are dependent from body weight. Therefore, we compared the effects of three high-fat and isocaloric diets varying only in their carbohydrate sources on brain activity of reward-related regions, and assessed whether brain activity is dependent on insulin sensitivity. Twenty-four minipigs underwent 18FDG PET brain imaging following 7-month intake of high-fat diets of which 20% in dry matter weight (36.3% of metabolisable energy) was provided by starch, glucose or fructose (n = 8 per diet). Animals were then subjected to a euglycemic hyperinsulinemic clamp to determine peripheral insulin sensitivity. After a 7-month diet treatment, all groups had substantial increases in body weight (from 36.02±0.85 to 63.33±0.81 kg; P<0.0001), regardless of the diet. All groups presented similar insulin sensitivity index (ISI = 1.39±0.10 mL·min-1·μUI·kg). Compared to starch, chronic exposure to fructose and glucose induced bilateral brain activations, i.e. increased basal cerebral glucose metabolism, in several reward-related brain regions including the anterior and dorsolateral prefrontal cortex, the orbitofrontal cortex, the anterior cingulate cortex, the caudate and putamen. The lack of differences in insulin sensitivity index and body weight suggests that the observed differences in basal brain glucose metabolism are not related to differences in peripheral insulin sensitivity and weight gain. The differences in basal brain metabolism in reward-related brain areas suggest the onset of cerebral functional alterations induced by chronic consumption of dietary sugars. Further studies should explore the underlying mechanisms, such as the availability of intestinal and brain sugar transporter, or the appearance of addictive-like behavioral correlates of these brain functional characteristics.
Parkinson's disease-related brain metabolic patterns and neurodegeneration in isolated REM sleep behavior disorder
<p><span><b>Objective</b>: To elucidate the role of Parkinson's disease (PD)-related brain metabolic patterns as a biomarker in isolated rapid-eye-movement sleep behavior disorder (iRBD) for future disease conversion.</span></p> <p><span><b>Method</b>: This is a prospective cohort study consisting of 30 iRBD patients, 25 de novo PD patients with a premorbid history of RBD, 21 long-standing PD patients on stable treatment and 24 healthy controls. iRBD group was longitudinally followed up. All participants underwent <sup>18</sup>F-Fluorodeoxyglucose (FDG) PET and were evaluated with olfaction, cognition, and the Movement disorders society-Unified PD Rating Scale (MDS-UPDRS) at baseline. From FDG-PET scans, we derived metabolic patterns from the long-standing PD group (PD-RP) and de novo PD group with RBD (dnPDRBD-RP). Subsequently, we calculated the PD-RP and dnPDRBD-RP scores in iRBD patients. We validated the metabolic patterns in each PD group and separate iRBD cohort (<i>n</i>=14).</span></p> <p><span><b>Result</b>: The two patterns significantly correlated with each other and were spatially overlapping yet distinct. The MDS-UPDRS motor scores significantly correlated with PD-RP (<i>p</i> = 0.013) but not with dnPDRBD-RP (<i>p</i> = 0.076). In contrast, dnPDRBD-RP correlated with olfaction in butanol threshold test (<i>p</i> = 0.018) in iRBD subjects, but PD-RP did not (<i>p</i> = 0.21). High dnPDRBD-RP in iRBD patients predicted future phenoconversion with all cut-off ranges from 1.5 to 3 standard deviations of the control value, whereas predictability of PD-RP was only significant in a partial range of cut-off.</span></p> <p><b>Conclusion:</b> The dnPDRBD-RP is an efficient neuroimaging biomarker that reflects prodromal features of PD and predicts phenoconversion in iRBD that can be applied individually.</p>
I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers
ClinicalTrials.gov study NCT00001771. IPD Sharing: Not stated. Countries: 1. Publications: 3.
MRI Measurement of Brain Metabolism Across the Sleep-Wake Cycle
ClinicalTrials.gov study NCT00117221. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effect of EGb761® on Brain Glucose Metabolism in Three Groups of Elderly Defined by Cognitive Functions
ClinicalTrials.gov study NCT00814346. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Ketones
ClinicalTrials.gov study NCT05778695. IPD Sharing: NO. Countries: 1. Publications: 0.
Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring
ClinicalTrials.gov study NCT07198490. IPD Sharing: Not stated. Countries: 0. Publications: 3.
The Interaction Between Diabetes and Estradiol on Human Brain Metabolism in Postmenopausal Women
ClinicalTrials.gov study NCT03681691. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Impact of Aripiprazole Once Monthly Medications on Changes in Brain Structure and Metabolism
ClinicalTrials.gov study NCT02237417. IPD Sharing: NO. Countries: 1. Publications: 0.
Exploring the Effect of Lactate Administration After Ischemic Stroke on Brain Metabolism
ClinicalTrials.gov study NCT04858139. IPD Sharing: NO. Countries: 1. Publications: 0.
Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram
ClinicalTrials.gov study NCT00183677. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Confirmed Autoimmune Encephalitis on Brain Glucose Metabolism
ClinicalTrials.gov study NCT06079294. IPD Sharing: YES. Countries: 1. Publications: 0.
Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Tributyrin Supplementation
ClinicalTrials.gov study NCT05446168. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Vigabatrin on Brain Blood Flow and Glucose Metabolism
ClinicalTrials.gov study NCT00001489. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Brain Energy Metabolism and Sleep in Adults
ClinicalTrials.gov study NCT03929302. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Effects of chronic consumption of sugar-enriched diets on brain metabolism and insulin sensitivity in adult Yucatan Minipigs
Open the record for dataset details and reuse information.
Parkinson’s disease-related brain metabolic patterns and neurodegeneration in isolated REM sleep behavior disorder
Open the record for dataset details and reuse information.
Induced pluripotent stem cell-derived cells model brain microvascular endothelial cell glucose metabolism
GEO Series GSE211648. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Role of Caveolin 1 in metabolic programming of fetal brain
GEO Series GSE214759. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Brain tumor stem cell dependence on glutaminase reveals a metabolic vulnerability through the amino acid deprivation response pathway
GEO Series GSE155300. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.