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615 results for “central nervous system”
A Study of Pertuzumab With High-Dose Trastuzumab for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer (MBC) With Central Nervous System (CNS) Progress
ClinicalTrials.gov study NCT02536339. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dose Finding Study of Gadavist in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)
ClinicalTrials.gov study NCT00862459. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Data from: eSnail: a transcriptome-based molecular resource of the central nervous system for terrestrial gastropods
To expand on emerging terrestrial gastropod molecular resources, we have undertaken transcriptome-based sequencing of the central nervous system (CNS) from six ecologically invasive terrestrial gastropods. Focusing on snail species Cochlicella acuta and Helix aspersa, and reticulated slugs Deroceras invadens, Deroceras reticulatum, Lehmannia nyctelia, and Milax gagates, we obtained a total of 367,869,636 high quality reads and compared them with existing CNS transcript resources for the invasive Mediterranean snail, Theba pisana. In total we obtained, 419,289 unique transcripts (unigenes) from 1,410,569 assembled contigs, with BLAST search analysis of multiple protein databases leading to the annotation of 124,268 unigenes, of which 92,544 mapped to NCBI non-redundant protein databases. We found that these transcriptomes have representatives in most biological functions, based on comparison of gene ontology, KEGG pathway, and protein family contents, demonstrating a high range of transcripts responsible for regulating metabolic activities and molecular functions occurring within the CNS. To provide an accessible genetic resource, we also demonstrate the presence of 66,687 microsatellites and 304,693 single nucleotide variants, which can be used for the design of potentially thousands of unique primers for functional screening. An online 'eSnail' database with a user-friendly web interface was implemented to query all the information obtained herein (http://soft.bioinfo-minzhao.org/esnail). We demonstrate the usefulness of the database through the mining of molluscan neuropeptides. As the most comprehensive CNS transcriptome resource for terrestrial gastropods, eSnail may serve as a useful gateway for researchers to explore gastropod CNS function for multiple purposes, including for the development of biocontrol approaches.
FIGURE 12. Central nervous systems. A in Taxonomy and anatomy of Amphiboloidea (Gastropoda: Heterobranchia: Archaeopulmonata)
FIGURE 12. Central nervous systems. A. Amphibola crenata (Martyn, 1786). B. Salinator fragilis (Lamarck, 1822). C. Lactiforis tropicalis sp. nov.. D. Lactiforis takii (Kuroda, 1928). E. Naranjia cf. swatowensis (Yen, 1939). F. Phallomedusa solida (Martens, 1878). G. Maningrida arnhemensis sp. nov.. Scale bar = 500 µm. Subcerebral and parapedal commissures are indicated on the figures for A. crenata, S. fragilis and P. s o l i d a, but not on the figures for other species as the presence of these structures is unconfirmed.
DistSNE: Distributed computing and online visualization of DNA methylation-based central nervous system tumor classification
<p><strong>The current state-of-the-art analysis of central nervous system (CNS) tumors through DNA methylation profiling relies on the tumor classifier developed by Capper and colleagues, which centrally harnesses DNA methylation data provided by users. Here, we present a distributed-computing-based approach for CNS tumor classification that achieves a comparable performance to centralized systems while safeguarding privacy. We utilize the t-distributed neighborhood embedding (t-SNE) model for dimensionality reduction and visualization of tumor classification results in two-dimensional graphs in a distributed approach across multiple sites (DistSNE). DistSNE provides an intuitive web interface (https://gin-tsne.med.uni-giessen.de) for user-friendly local data management and federated methylome-based tumor classification calculations for multiple collaborators in a DataSHIELD environment. The freely accessible web interface supports convenient data upload, result review, and summary report generation. Importantly, increasing sample size as achieved through distributed access to additional datasets allows DistSNE to improve cluster analysis and enhance predictive power. Collectively, DistSNE enables a simple and fast classification of CNS tumors using large-scale methylation data from distributed sources, while maintaining the privacy and allowing easy and flexible network expansion to other institutes. This approach holds great potentialfor advancing human brain tumor classification and fostering collaborative precision medicine in neuro-oncology. </strong></p>
Division of labor for defensive retaliation and preemption by the peripheral and central nervous systems in the nudibranch Berghia stephanieae
<p>Contained in this depository are the kinematic data, associated analyses, and original MATLAB code accompanying the paper "Division of labor for defensive retaliation and preemption by the peripheral and central nervous systems in the nudibranch <em>Berghia stephanieae.</em>" </p>
Incidence trends of childhood central nervous system tumors in Finland 1990–2017
<p>Frequency tables of the dataset provided by the Finnish cancer registry and used for the submitted manuscript Incidence trends of childhood central nervous system tumors in Finland 1990–2017 by the above-mentioned authors.<br> </p>
Validation of LEXO® End-Effector Robot-assisted Training in Patients with Gait Deficits after Central Nervous System Diseases. A Descriptive Cross-sectional Study.
Open the record for dataset details and reuse information.
Fig. 15 in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 15 Loligo vulgaris hatchling: histology of the head region (transversal sections; Richardson staining; see also interactive supplementary figure 5). a Overview with selected planes B-H (3D reconstruction; left side view). b Brachial crown with arms and tentacles. c Base of brachial crown near mouth opening. d Midline of eyes, radula. e Lobus opticus just behind the eyes, anterior basal lobe. f Central lobus opticus with optic commissure, pedal lobe. g Posterior lobus opticus, statocysts with statoliths. h Palliovisceral lobes just behind the lobus opticus, statocysts. Labels: a 1–4=arms 1–4, abl=anterior basal lobe, aco=anterior chamber organ, doc=dorsal optic commissure, es=esophagus, ey= eye, fu=funnel, ibl=inferior buccal lobe, le=lens, ipl=inner plexiform layer, mcl=magnocellular lobe, noai=inferior anterior oculomotoric nerve, of=olfactory organ, ofl=olfactory lobe, ol=optic lobe (medullar core), opl=outer plexiform layer, pdc=peduncle commissure, pdl= peduncle lobe, pl=pedal lobe, pvl=palliovisceral lobe, ra=radula, re=retina, sl=statolith, st=statocyst, svl=subvertical lobe, t=tentacle, tp=tentacular pocket, voc=ventral optic commissure, vtl=vertical lobe; arrowhead crossing of first-order giant axons
Fig. 14 in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 14 Idiosepius notoides hatchling: histology of the head region (transversal sections; Richardson staining; see also interactive supplementary figure 4). a Overview with selected planes B-H (3D reconstruction; left side view). b Brachial crown with arms and tentacles. c Base of brachial crown near mouth opening, buccal mass. d Midline of eyes, brachial lobe. e Lobus opticus just behind eyes. f Central lobus opticus with optic commissure, anterior funnel. g Posterior lobus opticus, statocysts with statoliths. h Palliovisceral lobes just behind the lobus opticus, statocysts. Labels: a 1–4=arms 1–4, bl=brachial lobe, bm=buccal mass, es= esophagus, ey=eye, fu=funnel, ifl=inferior frontal lobe, le=lens, mbl=median basal lobe, np=pallial nerve, oc=optic commissure, of=olfactory organ, ol=optic lobe (medullar core), opl=outer plexiform layer, pdl=peduncle lobe, pl=pedal lobe, pvl=palliovisceral lobe, ra=radula, rc=radula cartilage, re=retina, sfl=superior frontal lobe, sl= statolith, st=statocyst, t=tentacle, tp=tentacular pocket
Fig. 11 in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 11 Sepia officinalis hatchling: histology of the head region (transversal sections; Richardson staining; see also interactive supplementary figure 1). a Overview with selected planes B-H (3D reconstruction; left side view). b Brachial crown with arms and tentacles. c Base of brachial crown near mouth opening. d Midline of eyes, buccal mass, and anterior funnel. e Lobus opticus just behind the eyes. f Central lobus opticus with optic commissure. g Posterior lobus opticus, statocysts with statoliths. h Palliovisceral lobes just behind the lobus opticus. Labels: a 1–4= arms 1–4, abl=anterior basal lobe, aco=anterior chamber organ, asg=anterior salivary gland, bl=brachial lobe, bm=buccal mass, cc=cerebral connective, dg=digestive gland, es=esophagus, ey=eye, fu=funnel, le=lens, mbl=median basal lobe, mcl= magnocellular lobe, np=pallial nerve, oc=optic commissure, of= olfactory organ, ol=optic lobe (medullar core), opl=outer plexiform layer, pdc=peduncle commissure, pl=pedal lobe, psd= posterior salivary duct, psg=posterior salivary gland, pvl=palliovisceral lobe, ra=radula, rc=radula cartilage, re=retina, sl=statolith, st=statocyst, t=tentacle, tp=tentacular pocket, vtl=vertical lobe
Fig. 10 3D in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 10 3D reconstruction of the anterior subesophageal mass (comparative ventral views). a Sepia officinalis, b Rossia macrosoma, c Sepietta obscura, d Idiosepius notoides, e Loligo vulgaris, f Octopus vulgaris. abrl=anterior brachial lobe, bl=brachial lobe, bmc=brachiomagnocellular connective, bpc= brachio-pedal connective, bpvc= brachio-palliovisceral connective, nas=superior antorbital nerve, noa=anterior oculomotoric nerve, noai=inferior anterior oculomotoric nerve, nopa= anterior inferior ophthalmic nerve, pbrl=posterior brachial lobe, pl=pedal lobe
Fig. 8 Supraesophageal neuropils. 3D in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 8 Supraesophageal neuropils. 3D reconstruction of the central nervous system around the brachial lobe (comparative left lateral and frontal views; enlarge to 100 % in the PDF viewer; A-F different scales). a Sepia officinalis, b Rossia macrosoma, c Sepietta obscura, d Idiosepius notoides, e Loligo vulgaris, f Octopus vulgaris. Labels: 14=olfactory nerve, 23=sympathic nerve, abl=anterior basal lobe, bbrc=bucco-brachial connective, cbc=cerebro-buccal connective, cbrc=cerebro-brachial
Fig. 7 Subesophageal neuropils. 3D in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 7 Subesophageal neuropils. 3D reconstruction of the central nervous system: supraesophageal and subesophageal neuropils (comparative left lateral and frontal views; enlarge to 100 % in the PDF viewer; A-F different scales). a Sepia officinalis, b Rossia macrosoma, c Sepietta obscura, d Idiosepius notoides, e Loligo vulgaris, f Octopus vulgaris. Labels: 1=inferior antorbital nerve, 2=superior antorbital nerve, 3=collar nerve, 4=crista nerve, 5=anterior funnel nerve, 6=median funnel nerve, 7=posterior funnel nerve, 8=anterior oculomotoric nerve, 9=inferior anterior oculomotoric nerve, 10=superior anterior oculomotoric nerve, 11=posterior oculomotoric nerve, 12=inferior posterior oculomotoric
Fig. 13 in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 13 Sepietta obscura hatchling: histology of the head region (transversal sections; b,c,e,h: Azan staining; d,f,g: Trichrome de Masson staining; see also interactive supplementary figure 3). a Overview with selected planes BH (3D reconstruction; left side view). b Brachial crown with arms and tentacles. c Beak and base of brachial crown. d Midline of eyes, brachial lobe. e Central lobus opticus just behind the eyes, anterior funnel. f Lobus opticus with optic commissure. g Posterior lobus opticus, statocysts with statoliths. h Stellate ganglion, gills, digestive gland. Labels: a 1–4=arms 1–4, aco= anterior chamber organ, bk=beak, bl=brachial lobe, dbl= dorsal basal lobe, dg=digestive gland, es=esophagus, ey=eye, fu=funnel, g=gill, ifl=inferior frontal lobe, le=lens, mbl=medi- an basal lobe, np=pallial nerve, oc=optic commissure, of=olfactory organ, ol=optic lobe (medullar core), opl=outer plexiform layer, pdc=peduncle commissure, pdl=peduncle lobe, pl= pedal lobe, re=retina, sbl=superior buccal lobe, sfl=superior frontal lobe, sg=stellate ganglion, sl=statolith, st=statocyst, t=tentacle, tp=tentacular pocket, vtl=vertical lobe
Fig. 4 in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 4 Comparative retina histology (ventral portion; transversal sections at the level of lens centers). a Sepia officinalis (Richardson), b Rossia macrosoma (Trichrome de Masson), c Sepietta obscura (Trichrome de Masson), d Idiosepius notoides (Richardson), e Loligo vulgaris (Richardson), f Octopus vulgaris (Azan). Labels: bsm=basal membrane, ds=distal segments of photoreptors, ps=proximal segments of photoreceptors, rp=retinal plexus, scn=supporting cell nuclei, arrowheads peripherically thickened eye cartilage
Fig. 9 in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 9 Comparative histology of the central nervous system II (transversal sections at the level of brachio-pedal connectives). a Sepia officinalis (Richardson), b Rossia macrosoma (Azan), c Sepietta obscura (Azan), d Idiosepius notoides (Richardson), e Loligo vulgaris (Richardson), f Octopus vulgaris (Azan). Labels: bpc=connectivum brachio- pedale, bpvc=connectivum brachio-pallioviscerale, nas=superior antorbital nerve, noa=anterior oculomotoric nerve, noai= inferior anterior oculomotoric nerve, nopa=anterior inferior ophthalmic nerve, pbrl=posterior brachial lobe
Fig. 12 in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 12 Rossia macrosoma hatchling: histology of the head region (transversal sections; Trichrome de Masson staining, except f: Azan staining; see also interactive supplementary figure 2). a Overview with selected planes B-H (3D reconstruction; left side view). b Base of brachial crown with arms and tentacles. c Base of brachial crown with buccal mass. d Midline of eyes, radula. e Central lobus opticus just behind the eyes. f Central lobus opticus with optic commissure. g Posterior lobus opticus, statocysts with statoliths. h Palliovisceral lobes just at the end of the optic lobes. Labels: a 1– 4=arms 1–4, aco=anterior chamber organ, bm=buccal mass, es= esophagus, ey=eye, fu=funnel, ibl=inferior buccal lobe, ifl=inferior frontal lobe, le=lens, mcl=magnocellular lobe, oc=optic commissure, ofl= olfactory lobe, ol=optic lobe (medullar core), opl=outer plexiform layer, pdl=peduncle lobe, pl=pedal lobe, pvl=palliovisceral lobe, ra=radula, re=retina, sl= statolith, st=statocyst, t=tentacle, tp=tentacular pocket, vtl=vertical lobe, ys=yolk sac
Fig. 3 in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 3 Comparative eye histology (transversal sections through lens centers; surface renderings of left retinae—not true to scale; gray arrowhead pointing rostrally). a Sepia officinalis (Richardson), b Rossia macrosoma (Trichrome de Masson), c Sepietta obscura (Trichrome de Masson), d Idiosepius notoides (Richardson), e Loligo vulgaris (Richardson), f Octopus vulgaris (Azan). Labels: aco=anterior chamber organ, cb=ciliary body, co=cornea, ir=iris, le=lens, ol=optic lobe, on=optic nerve, re=retina, arrows: septum, black arrowheads: lids
Fig. 1 Midsagittal section through a in Comparative 3D microanatomy and histology of the eyes and central nervous systems in coleoid cephalopod hatchlings
Fig. 1 Midsagittal section through a cephalopod-coleoid central nervous system with its main neuropils (Loligo vulgaris). a Profiles of subesophageal and supraesophageal masses with neuropils (light gray) and perikaryal layers (dark gray)(compare, e.g., with Novicki et al. 1990, Fig. 14). b Digital YZ-reslice with labeled neuropils (2D). c Digital YZ-reslice with labeled neuropils (3D, same colors as in b). Labels: abl=anterior basal lobe, bl=brachial lobe, dbl=dorsal basal lobe, es=esophagus, ifl=inferior frontal lobe, mbl=median basal lobe, pcl=precommissural lobe, pdc=peduncle commissure, pl= pedal lobe, pvl=palliovisceral lobe, sfl=superior frontal lobe, svl= subvertical lobe, vtl=vertical lobe
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.