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85 results for “characterization method”
Artificial Intelligence-based Image Processing Methods to Advance the Characterization of Polycystic Kidney Disease
ClinicalTrials.gov study NCT06688981. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Facile synthesis of Cu2O nanorods in the presence of NaCl by SILAR method and its characterizations
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Data from: Characterization of self-assembled silver nanoparticle ink based on nanoemulsion method
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Data from: Linking genetic kinship and demographic analyses to characterize dispersal: methods and application to Blanding’s turtle
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Data from: Comparison of 454 pyrosequencing methods for characterizing the major histocompatibility complex of nonmodel species and the advantages of ultra deep coverage
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Raw in vitro screening data and R scripts for: A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model
<p>Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes are an established model for testing potential chemical hazards. Inter-individual variability in toxicodynamic sensitivity has also been demonstrated <i>in vitro</i>; however, quantitative characterization of the population-wide variability has not been fully explored. We sought to develop a method to address this gap by combining a population-based iPSC-derived cardiomyocyte model with Bayesian concentration-response modeling. A total of 136 compounds, including 44 pharmaceuticals and 82 environmental chemicals, were tested in iPSC-derived cardiomyocytes from 43 non-diseased humans. Hierarchical Bayesian population concentration-response modeling was conducted for five phenotypes reflecting cardiomyocyte function or viability. Toxicodynamic variability was quantified through the derivation of chemical- and phenotype-specific variability factors (TDVF). Toxicokinetic modeling was used for probabilistic <i>in vitro</i>-to-<i>in vivo </i>extrapolation in order to derive population-wide margins of safety (MOS) for pharmaceuticals and margins of exposure (MOE) for environmental chemicals. Pharmaceuticals were found to be active across all phenotypes. Over half of tested environmental chemicals showed activity in at least one phenotype, most commonly positive chronotropy. TDVF estimates for the functional phenotypes were greater than those for cell viability, usually exceeding the generally-assumed default of ~3. Population variability-based MOS for pharmaceuticals were correctly predicted to be relatively narrow, between 10-100; however, MOE for environmental chemicals, based on population exposure estimates, generally exceeded 1000, suggesting they pose little risk at general population exposures even to sensitive sub populations. This study represents a first of its kind human <i>in vitro</i> model that can be used to characterize toxicodynamic population variability in cardiotoxic risk.</p>
targets for Scan-Centric, Frequency-Based Method for Characterizing Peaks from Direct Injection Fourier transform Mass Spectrometry Experiments
<p>_targets folder for the scan-centric, frequency-based peak-characterization manuscript</p>
Development of a Method for Thermogalvanic Characterization of Li-Ion Electrodes: A Case Study in Thin-Film Anatase TiO2
<p>This dataset contains the raw data for the publication "Development of a Method for Thermogalvanic Characterization of Li-Ion Electrodes: A Case Study in Thin-Film Anatase TiO2" by Hubrechtsen et al, published in Chemistry of Materials. The upload includes all data for the original figures presented in the main paper and the supporting information, organized in labelled folders containing raw data and the corresponding figure. </p>
Using Rheological Methods to Characterize Cystic Fibrosis (CF) Sputum and the Effects of Mucoactive Agents
ClinicalTrials.gov study NCT00758771. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Development, characterization and comparisons of targeted and non-targeted metabolomics methods
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Raw in vitro screening data and R scripts for: A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model
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Data from: Mie scattering and microparticle based characterization of heavy metal ions and classification by statistical inference methods
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Characterization of Functional Methylomes by Different Methods to Identify Novel Disease Associated Variants
GEO Series GSE59524. Homo sapiens. 24 samples. Type: Methylation profiling by genome tiling array.
Dts-seq: a simple method of library preparation for a highly reproducible characterization of the tRNA epitranscriptome by deep sequencing
GEO Series GSE135937. Escherichia coli str. K-12 substr. MG1655. 15 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Optimization of Tissue Digestion Methods for Characterization of Photoaged Skin by Single Cell RNA Sequencing Reveals Preferential Enrichment of T Cell Subsets
GEO Series GSE250390. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature
GEO Series GSE214326. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
A multiparametric extraction method for the molecular characterization of Vn96-isolated plasma extracellular vesicles
GEO Series GSE133991. Homo sapiens. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Monitoring Nivolumab binding as a method to clarify the residual therapeutic effects and to characterize the immune profile in antibody bound T cells in previously treated non-small cell lung cancer p
GEO Series GSE100860. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Figure 3 from: Tzankova D, Mateeva A, Mitkov J, Peikova L, Georgieva M (2022) Development and validation of RP-HPLC method for analytical characterization of the anabolic steroid Methenolone acetate in food supplements. Pharmacia 69(1): 151-155. https://doi.org/10.3897/pharmacia.69.e78176
Figure 3 Chromatogram of Methenolone standard solution.
Figure 2 from: Tzankova D, Mateeva A, Mitkov J, Peikova L, Georgieva M (2022) Development and validation of RP-HPLC method for analytical characterization of the anabolic steroid Methenolone acetate in food supplements. Pharmacia 69(1): 151-155. https://doi.org/10.3897/pharmacia.69.e78176
Figure 2 Linearity of the developed RP-HPLC method.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.