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1,159 results for “covid-19 vaccine”
Getting Asian Americans INFORMED to Facilitate COVID-19 Testing and Vaccination
ClinicalTrials.gov study NCT04893265. IPD Sharing: YES. Countries: 1. Publications: 1.
COVID-19 Vaccine Hesitancy Counseling Intervention for Pharmacists
ClinicalTrials.gov study NCT05926544. IPD Sharing: YES. Countries: 1. Publications: 5.
Characterization of the anti-spike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies
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Manifestation of Health Denialism in Attitudes Toward COVID-19 Vaccination: A Qualitative Study
<p>The transcripts of the in-depth interviews used for the qualitative analysis of the manifestations of denializm in attitudes toward COVID-19 preventive measures and other opinions about the pandemic.</p>
A cross-sectional survey of COVID-19 testing status among vaccine recipients in Gombe, North-Eastern Nigeria
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COVID-19 vaccine uptake data set
<p>The novel Coronavirus Disease 19 (COVID-19) caused devastating effects globally, and healthcare workers were among the most affected by the pandemic. Despite healthcare workers being prioritized in COVID-19 vaccination globally and in Ghana, hesitancy to receive the vaccines resulted in delayed control of the pandemic. In Ghana, healthcare workers had a vaccine acceptance of 39.3% before the vaccine rollout. Consequently, this study assessed the uptake of COVID-19 vaccination and associated factors among healthcare workers in Ghana in the post-vaccine roll-out period. This was an analytical cross-sectional study that used a semi-structured questionnaire to collect data on COVID-19 vaccination uptake and influencing factors. 256 healthcare workers were selected in Ayawaso West Municipality of Ghana using a stratified random sampling approach. Descriptive statistics were used to examine socio-demographic factors and Likert scale responses. Bivariable and Multivariable logistic regression were performed using IBM SPSS version 22 to identify predictors of vaccine uptake and a statistical significance was declared at p<0.05. More than three-fourths of participants 220 (85.9%) had received at least one dose of the COVID-19 vaccination, while 36 (14.9%) were hesitant. More than half 139 (54.3%) had adequate knowledge about COVID-19 vaccination and the majority 188 (73.4%) had positive perceptions about its effectiveness. Moreover, 218 (85.2%) of HCWs had a positive attitude towards COVID-19 vaccination. Positive attitude towards COVID-19 vaccination (AOR = 4.3; 95% CI: 1.4, 13.0) and high cues to action (AOR = 5.7; 95% CI: 2.2, 14.8) were the factors that significantly predicted uptake of COVID-19 vaccination among healthcare workers. COVID-19 vaccination among HCWs in Ghana is promising. However, hesitancy to receive the vaccination among a significant proportion of HCWs raises concerns. To ensure vaccination of all healthcare workers, interventions to promote vaccination should target key determinants of vaccination uptake, such as attitude towards the vaccination and cues to action.</p>
How did the US and UK markets react to the COVID-19 vaccines' announcements? A preliminary assessment
<p>This data has been used for the preparation of the manuscript: 'How did the US and UK markets react to the COVID-19 vaccines’ announcements? A preliminary assessment'</p>
Protective effect conferred by prior infection and vaccination on COVID-19 in a healthcare worker cohort in South India
<p><span>The emergence of newer variants with the immune escape potential raises concerns about breakthroughs and re-infections resulting in future waves of infection. We examined the protective effect of prior COVID-19 disease and vaccination on infection rates among a cohort of healthcare workers (HCW) in South India during the second wave driven mainly by the delta variant. </span><span>Symptomatic HCWs were routinely tested by RT-PCR as per institutional policy. Vaccination was offered to all HCWs in late January, and the details were documented. We set up a non-concurrent cohort to document infection rates and estimated protective efficacy of prior infection and vaccination between 16th Apr to 31st May 2021, using a Cox proportional hazards model with time-varying covariates adjusting for daily incidence.</span></p> <p><span>Between June 2020 and May 2021, 2735 (23.9%) of 11,405 HCWs were infected, with 1412, including 32 re-infections, reported during the second wave. 6863 HCWs received two doses of vaccine and 1905 one dose. The protective efficacy of prior infection against symptomatic infection was 86.0% (95% CI 76.7% - 91.6%). Vaccination combined with prior infection provided 91.1% (95% CI 84.1% - 94.9%) efficacy. In the absence of prior infection, vaccine efficacy against symptomatic infection during the second wave was 31.8% (95% CI 23.5% – 39.1%).</span></p> <p><span>Prior infection provided substantial protection against symptomatic re-infection and severe disease during a delta variant-driven second wave in a cohort of health care workers.</span></p>
Misconceptions about COVID-19 vaccine among adults in Saudi Arabia and their associated factor
<p>It is of the utmost importance for the elements that influence public compliance to the COVID-19 vaccine to be assessed, including misconceptions, rumors, and conspiracy theories. Hence our study aimed to estimate the distribution of the most common misconceptions and their predictors in Saudi Arabia. We distributed an online questionnaire to participants who were 18 years or older at the time of the survey, which included four sections: demographic characteristics of participants, level of their education, their sources of information, and perception of participants regarding eleven of the most common misconceptions in the community.</p> <p>An evaluation of the relationships between different predictors and acceptance of these misconceptions was conducted using ordinal logistic regression; the most widely accepted misconception was that the vaccine has serious side effects, with 34.8% of participants reporting this.</p> <p><strong>Accepting this misinformation</strong> Factors that were significantly associated with acceptance or refusal of misconceptions were:</p> <p><span>Gender</span>, as females in this survey significantly accept rumors more than males (p<0.001);</p> <p><span>Educational level</span>, especially secondary school, was associated with a significant decrease in acceptance of misconceptions (p=0.001);</p> <p><span>Information source</span>. 60.5% of participants use social media as their primary source of information, and it was also a significant positive predictor of acceptance of misconceptions (p=0.034).</p> <p>It is of utmost importance to increase assurance in the safety of the vaccine, as it was the most accepted misconception, and to address the elements that affect believing rumors among the population.</p>
Dataset for The Effects of COVID-19 Vaccine Mandates in Hawaii
<p>This is the data used for the paper: <em>The Effects of COVID-19 Vaccine Mandates in Hawaii</em> published in Vaccines (2022). It includes the following: (1) foot-traffic data provided by SafeGraph; (2) COVID-19 positive case data provided by the State of Hawaii Department of Health; (3) Population data from the United States Census Bureau estimates from the 2020 Census; (4) Weekly vaccination data provided by the State of Hawaii Department of Health.</p>
COVID-19 Vaccine Hesitancy in the Pandemic's Third Year
<p>Dataset and code for June 2022 study, "<strong>COVID-19 Vaccine Hesitancy in the Pandemic's Third Year"</strong></p>
Mass Cytometry (CyTOF) FCS files from Priest et al. 2024. Human PBMC from longitudinal analysis of COVID-19, Bacterial Sepsis, mRNA vaccination cohorts.
<p>Mass Cytometry (CyTOF) FCS files from Priest et al. "Non-classical CD45RB<sup>lo</sup> memory B-cells are the majority of circulating antigen-specific B-cells following mRNA vaccination and COVID-19 infection." Research Square 2024. </p> <p>Files are already normalised, debarcoded, gated, batch corrected and compensated as described in Priest et al. </p> <p>Data is from Human PBMCs of londitudanal cohorts of Severe COVID-19, Sepsis and mRNA vaccine recipients. </p> <p>Samples were barcoded, mixed and then split magnetically before staining with seperate antibody panels for CD3+ (CD4, Treg, Tfh, CD8, gdT) or CD3- (B cells, DC, NK, Monocytes) to give approximatly 1280 FCS files from 218 individuals. </p> <p>A follow up experiment with a B-cell specific panel and Tetramers is included. </p> <p>Patient level metadata and antibody panel details are included. </p> <p> </p>
Contextualization of enablers and barriers for COVID-19 vaccine uptake among adult tuberculosis patients attending selected clinics in Nairobi County, Kenya
<p>Although vaccination is a cost-effective, equitable, and impactful public health intervention in curbing the spread of infectious disease, low uptake is a significant concern, especially among high-risk population groups. Nearly half of the population is unvaccinated in Nairobi, yet there is a shortage of vaccination information on vulnerable tuberculosis (TB) patients. The interplay of factors influences uptake, and protecting this vulnerable group and the general population from severe disease, hospitalization, and deaths is worthy. The purpose of this study is to determine the prevalence and individual-level enablers and barriers to COVID-19 vaccine uptake among adult TB patients attending selected clinics in Nairobi County, Kenya. This cross-sectional mixed-method study was conducted at TB clinics across six sub-counties in Nairobi County. It included 388 participants sampled from each clinic's TB register. Quantitative data was collected using a questionnaire, and qualitative data was collected through key informant interviews and focus group discussions. Quantitative data was analyzed using descriptive statistics (frequencies and percentages for categorical variables and mean standard deviation for continuous variables) and inferential statistics (logistic regression). Qualitative data was analyzed through deductive coding and thematic analysis. The prevalence of COVID-19 vaccination was 46.1%, with 38.1% receiving complete vaccination. Mistrust in vaccine management (adjusted odds ratio (aOR)= 0.075, 95% confidence interval (CI): 0.025-0.229, <em>p </em><0.001) was a significant barrier to COVID-19 vaccine uptake. Perceived covid-19 susceptibility (aOR = 2.901, 95% CI: 1.258-6.688, <em>p </em>= 0.012) and perceived covid-19 seriousness (aOR = 3.294, 95% CI: 1.130-9.604, <em>p </em>= 0.029) were significant enablers of COVID-19 vaccine uptake. Qualitative themes related to individual-level barriers and enablers of COVID-19 vaccine uptake were fear of side effects, stigma, myths, and mistrust in the messaging for barriers and desire to protect others and risk perception as enablers. The study revealed critical individual-level factors related to COVID-19 vaccine uptake.</p>
Data from: Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial
<p>Morbidity and mortality attributable to COVID-19 is devastating global health systems and economies. Bacillus Calmette Guérin (BCG) vaccination has been in use for many decades to prevent severe forms of tuberculosis in children. Studies have also shown a combination of improved long-term innate or trained immunity (through epigenetic reprogramming of myeloid cells) and adaptive responses after BCG vaccination, which leads to non-specific protective effects in adults. Observational studies have shown that countries with routine BCG vaccination programs have significantly less reported cases and deaths of COVID-19, but such studies are prone to significant bias and need confirmation. To date, in the absence of direct evidence, WHO does not recommend BCG for the prevention of COVID-19. This project aims to investigate in a timely manner whether and why BCG-revaccination can reduce infection rate and/or disease severity in health care workers during the SARS-CoV-2 outbreak in South Africa. </p> <p>These objectives will be achieved with a blinded, randomised controlled trial of BCG revaccination versus placebo in exposed front-line staff in hospitals in Cape Town. Observations will include the rate of infection with COVID-19 as well as the occurrence of mild, moderate or severe ambulatory respiratory tract infections, hospitalisation, need for oxygen, mechanical ventilation or death. HIV-positive individuals will be excluded. Safety of the vaccines will be monitored. A secondary endpoint is the occurrence of latent or active tuberculosis. Initial sample size and follow-up duration is at least 500 workers and 52 weeks. Statistical analysis will be model-based and ongoing in real time with frequent interim analyses and optional increases of both sample size or observation time, based on the unforeseeable trajectory of the South African COVID-19 epidemic, available funds and recommendations of an independent data and safety monitoring board. The study will be supported by a novel 3D lung organoid model of SARS-CoV-2 infection system that can mimic the cascade of immunological events after SARS-CoV-2 infection to determine and analyse the contribution of cellular components to the impact of BCG revaccination in this study.</p> <p>Given the immediate threat of the SARS-CoV-2 epidemic the trial has been designed as a pragmatic study with highly feasible endpoints that can be continuously measured. This allows for the most rapid identification of a beneficial outcome that would lead to immediate dissemination of the results, vaccination of the control group and outreach to the health authorities to consider BCG vaccination for all qualifying health care workers.</p>
Simulation results for "COVID-19 vaccination in Sindh Province, Pakistan: a modelling study of health impact and cost-effectiveness"
<p>The high-performance computing results for raw epidemiological simulations and quantiled scenarios associated with https://doi.org/10.1101/2021.02.24.21252338.</p> <p>All results stored as compressed rds files of data.table objects (use-able as data.frame objects) for use with R programming language.</p>
Supplemental Material: Page Length Calculations for BMJ EBM Manuscript on COVID-19 Vaccine Transparency
<p>Supplemental Material: Page Length Calculations for COVID-19 Vaccine Transparency Manuscript</p>
Looking in the medicine cabinet: methods for using real-world data to assess the impact of measles, mumps and rubella (MMR) and recombinant adjuvanted varicella-zoster vaccines on coronavirus disease 2019 (COVID-19) prevention and case fatality
<p>Supplementary File S1. 20210712_vx_off_target_pubdraft_S1 (Tables, Graphs and scripts associated with publication)</p> <p>Data file 1. Basic_Analysis.R (descriptive analysis script in R, for use with cleaned data files 3, 4 and 6)<br> Data file 2. Cleaning (Script demonstrating how Cerner data was cleaned upon download)<br> Data file 3. COVID_all_cleaned (CSV file with all COVID+ subjects in Cerner institutions)<br> Data file 4. COVID_mmr_data_cleaned (CSV file with COVID+ patients between 25-64 years old, including institution id, age category, gender, whether patient is in emergency department or inpatient, flu vaccine history, MMR vaccine history and mortality outcomes)<br> Data file 5. COVID_mmr_data_matched (CSV file matching MMR vaccine-exposed cases to controls based on propensity scores)<br> Data file 6. COVID_zoster_data_cleaned (CSV file with COVID+ patients above 50 years old, including institution id, age category, gender, whether patient is in emergency department or inpatient, flu vaccine history, zoster vaccine history and mortality outcomes)<br> Data file 7. COVID_zoster_data_matched (CSV file matching zoster vaccine-exposed cases to controls based on propensity scores)<br> Data file 8. General_25_64_data_cleaned (CSV file, all patients in Cerner institutions between 25 – 64 years old, including institution id, age category, gender, whether patient is in emergency department or inpatient, flu vaccine history, MMR vaccine history, SARS-CoV-2 infection and COVID-19 mortality outcomes ).<br> Data file 9. General_over50_data_cleaned (CSV file, all patients in Cerner institutions above 50 years old, including institution id, age category, gender, whether patient is in emergency department or inpatient, flu vaccine history, zoster vaccine history, SARS-CoV-2 infection and COVID-19 mortality outcomes).<br> Data file 10. Included_tenants (CSV file, institution IDs whose contributed cases comprise at least 0.5% of the aggregate sample size).<br> Data file 11. MMR_ps (R script to run for MMR-related files analysis)<br> Data file 12. Zoster_ps (R script to run for zoster-related files analysis)</p>
University students' adherence and vaccination attitude during the COVID-19 pandemic
<p>Data on university students' adherence and vaccination attitudes, accompanying the manuscript a manuscript (in press). </p> <p>Data collection took place between November 23rd and December 21st, 2020.</p> <p>The sample consists of German-speaking university students, recruited at Innsbruck Universities.</p> <p> </p> <p>Scale Sources: <br> Reactance - COSMO COVID-19 Snapshot Monitoring <br> Betsch, C., Korn, L., Felgendreff, L., Eitze, S., Schmid, P., Sprengholz, P., Wieler, L., Schmich, P., Stollorz, V., Ramharter, M., Bosnjak, M., Omer, S., Thaiss, H., Bock, F. de, & Rüden, U. von (2020). <em>Covid-19 Snapshot Monitoring (COSMO Germany) - Welle 27</em>. PsychArchives. https://doi.org/10.23668/PSYCHARCHIVES.4381</p>
Survey data of the health literacy on COVID-19 and COVID-19 vaccination in Indonesia
<p><span><strong>Introduction</strong>: </span><span>Health literacy on COVID-19 and COVID-19 vaccination is valuable during the pandemic. The objective of this study was to determine the levels of health literacy about the COVID-19 vaccine and vaccination (Vaccine and Vaccination literacy—VL) in the Indonesian adult general population, assessing the perceptions of the respondents/interviewees about current adult immunization and beliefs about vaccination in general, and analyzing correlations of these variables with the VL levels.</span><span> </span></p> <p><span><strong>Methods</strong>: </span><span>A rapid survey was administered via the web. Data were analyzed using descriptive and inferential stats; the internal consistency of the VL scales was assessed through Cronbach's alpha coefficient, and a Principal Component Analysis (PCA) was conducted to investigate how the questions of the functional and interactive-critical VL scales were related to one another and whether the underlying components (factors) and each question's load on the components could be identified as anticipated. An alpha level lesser than 0.05 was considered significant.</span></p> <p><span><strong>Results</strong>: </span><span>Answers to functional- and interactive/ critical- VL questions showed good/ acceptable internal consistency (Cronbach's alpha = 0.817 and 0.699, respectively), lowest values observed were 0.806 for functional scale and 0.640 for the interactive-critical scale. PCA showed two components accounting for 52.45% of the total variability. Approximately 60% of respondents were females (n=686). Almost all respondents used the internet to seek information regarding COVID-19 and COVID-19 vaccination. Many used at least one social media actively with 74.4% of respondents sometimes believing the validity of this information.</span></p> <p><span><strong>Conclusions:</strong> </span><span>High scores were observed in both functional- and interactive/ critical-VL, and were quite balanced between genders in the prior VL and higher in females for the latter; these were also closely related to the educational level and age group. It is crucial to increase public health literacy on managing the pandemic.</span></p>
Raw Data for the article: Analysis of the Specific Immune Response after the Third Dose of mRNA COVID-19 Vaccines in Organ Transplant Recipients: Possible Spike-S1 Reactive IgA Signature in Protection from SARS-CoV-2 Infection
<p><strong>Background:</strong> Several studies have indicated that anti-SARS-CoV-2 mRNA vaccinations are less effective in inducing robust immune responses among solid organ transplant recipients (SOTRs) compared with the immunocompetent. The third dose of vaccine in SOTRs showed promising results of immunogenicity, even though clinical studies have suggested that immunocompromised subjects are less likely to build a protective immune response against SARS-CoV-2 resulting in lower vaccine efficacy for the prevention of severe COVID-19. <strong>Methods:</strong> Serological IgG and IgA were analyzed through CLIA or ELISA, respectively, while Spike-specific T cells were detected by ELISpot assay after the second and third dose of vaccine in 43 SOTRs. <strong>Results:</strong> The third dose induced an improvement in antibody response against SARS-CoV-2. We also reported a strong correlation between specific humoral and cellular responses after the third dose, even though we did not see significant changes in the magnitude of the SARS-CoV-2-specific T cell response. SOTRs who contracted the SARS-CoV-2 infection after the third dose, despite eliciting a positive IgG response, failed to mount an anti-Spike-S1 IgA response, both after the third dose and after SARS-CoV-2 infection. <strong>Conclusions:</strong> We can conclude that serum IgA detection can be helpful, along with IgG detection, for the evaluation of vaccine efficacy, principally in fragile subjects at high risk of infection.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.