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985 results for “cytotoxicity”
Fig. 5 in The cytotoxic activity of Sponges and Tunicates from Turkish Aegean Sea
Fig. 5 — Cell viability of SH-SY5Y cell line with various extract concentrations treatment for 24 h
Fig. 3 in The cytotoxic activity of Sponges and Tunicates from Turkish Aegean Sea
Fig. 3 — Cell viability of AGS cell line with various extract concentrations treatment for 24 h
Fig. 2 in The cytotoxic activity of Sponges and Tunicates from Turkish Aegean Sea
Fig. 2 — Microscopic images of L929 cells treated with extracts for 24 h (Scale bar: 200 µm)
Fig. 1 in The cytotoxic activity of Sponges and Tunicates from Turkish Aegean Sea
Fig. 1 — Cell viability of L929 cell line with various extract concentrations treatment for 24 h
Figure 6 in Molecular docking studies and evaluation of the antiretroviral activity and cytotoxicity of the species Lafoensia pacari Saint-Hilaire
Figure 6. Structures of Ellagic Acid, Gallic Acid, α and β Punicalagins.
Figure 3 in Cytotoxicity of extracts and compounds isolated from Croton echioides in animal tumor cell (HTC)
Figure 3. Clerodan diterpenes tested.
A bioactive compound isolated from Duku (Lansium domesticum Corr) fruit peels exhibits cytotoxicity against T47D cell line
<p><strong>Background: </strong>Breast cancer is a major health problem for women globally. Many attempts have been promoted to cure cancer by finding new anticancer medicines from natural resources. Despite the richness of biodiversity discovered, there are some natural resources that remain unexplored. Fruit peels of Duku (<em>Lansium domesticum</em> Corr.) are rich with compounds that may have the potential to be developed as anticancer drugs. This study aimed to isolate cytotoxic compounds from the fruit peels of <em>L. domesticum</em> and assess their cytotoxic nature against T47D cells.</p> <p><strong>Methods: </strong>Powdered peels were macerated with ethyl acetate and the filtrate was evaporated to give EtOAc extract A. Dried extract A was triturated with n-hexane to give n-hexane soluble fraction B and insoluble fraction C. The cytotoxic nature of these three samples were assessed using MTT assay using T47D cells and doxorubicin as a control</p> <p><strong>Results: </strong>Fraction C that showed the smallest IC<sub>50</sub> (25.56 + 0.64µg/mL) value compared to extract A and fraction BFraction C was further fractionated by vacuum liquid chromatography to give 6 subfractions. Subfraction 2 showed a single compound based on thin layer chromatography, and this compound was identified as Lamesticumin A on the basis of its spectroscopic data. Lamesticumin A demonstrated cytotoxic activity against T47D cell lines with an IC<sub>50</sub> value of 15.68 + 0.30µg/mL.</p>
Figure 2 in The employment of a conformal polydopamine thin layer reduces the cytotoxicity of silver nanoparticles
Figure 2. Cell viability test of NP systems at different concentrations.
Insights into Heterocycle Biosynthesis in the Cytotoxic Polyketide Alkaloid Janustatin A from a Plant-Associated Bacterium
<p>Data underlying the manuscript 'Insights into Heterocycle Biosynthesis in the Cytotoxic Polyketide Alkaloid Janustatin A from a Plant-Associated Bacterium' by Leopold-Messer, Chawengrum and Piel.</p> <p>The repository contains:</p> <p>Sequencing data - Genbanks files of construct designs and ab1 files from Sanger sequencing. Contains both plasmids used to construct mutants, as well as sequencing data from final mutants.</p> <p>NMR data - MestReNova files of compounds 2-4.</p> <p>HPLC-MS data - Raw data collected on Thermo-Fisher instruments for the purified compounds (1-4) and the extract of all mutants. </p> <p>EICs - extracted ion chromatograms used to analyse the metabolic differences between mutants. These data are based on the raw files.</p> <p>Bioactivity data - cytotoxicity data of compounds 1-4. </p>
Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates
<p><strong><span>Background</span></strong><span>: Effective anti-tumor immune responses are mediated by T cells and require organized, spatially coordinated interactions within the tumor microenvironment (TME). Understanding coordinated T-cell behavior and deciphering mechanisms of radiotherapy resistance mediated by tumor stem cells will advance risk stratification of oropharyngeal cancer (OPSCC) patients treated with primary chemoradiotherapy (RCTx). </span></p> <p><span><strong>Methods</strong>:</span> <span>To determine the role of CD8 T cells (CTL) and tumor stem cells in response to RCTx, we employed multiplex immunofluorescence stains on pre-treatment biopsy specimens from 86 advanced OPSCC patients and correlated these quantitative data with clinical parameters. Multiplex stains were analyzed at the single-cell level using QuPath and spatial coordination of immune cells within the TME was explored using the R-package Spatstat. </span></p> <p><span><strong>Results</strong>:</span><span> Our observations demonstrate that a strong CTL-infiltration into the epithelial tumor compartment (HR for overall survival, OS: 0.35; p<0.001) and the expression of PD-L1 on CTL (HR: 0.36; p<0.001) were both associated with a significantly better response and survival upon RCTx. As expected, p16 expression was a strong predictor of improved OS (HR: 0.38; p=0.002) and correlated with overall CTL infiltration (</span><span>r: 0.358, p<0.001). By contrast, tumor cell proliferative activity, expression of the tumor stem cell marker CD271 and overall CTL infiltration, regardless of the affected compartment, were not associated with response or survival. </span></p> <p><span><strong>Conclusion</strong>: </span><span>In this study, we could demonstrate the clinical relevance of the spatial organization and the phenotype of CD8 T cells within the TME. In particular, we found that the infiltration of CD8 T cells specifically into the tumor cell compartment was an independent predictive marker for response to chemoradiotherapy, which was strongly associated with p16 expression. Meanwhile, tumor cell proliferation and the expression of stem cell markers showed no independent predictive effect in response to RCTx and require further study.</span></p>
TAA Specific Cytotoxic T Lymphocytes in Patients With Pancreatic Cancer
ClinicalTrials.gov study NCT03192462. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Investigator's Choice of Standard Chemotherapy in Adults Receiving First Cytotoxic Chemotherapy for Metastatic or Advanced Non-Squamous
ClinicalTrials.gov study NCT02264990. IPD Sharing: YES. Countries: 20. Publications: 1.
Metabolically Optimized, Non-cytotoxic Low Dose Weekly Decitabine/Venetoclax in MDS and AML
ClinicalTrials.gov study NCT05184842. IPD Sharing: NO. Countries: 1. Publications: 1.
Sipuleucel-T With Immediate vs. Delayed Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Blockade for Prostate Cancer
ClinicalTrials.gov study NCT01804465. IPD Sharing: NO. Countries: 1. Publications: 1.
Interleukin-17A signaling promotes CD8+ T cell cytotoxicity against West Nile virus infection through enhancing PI3K-mTOR-mediated metabolism
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Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts
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Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates
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Data from: Acute cytotoxicity and increased vascular endothelial growth factor after in vitro nitrogen mustard vapor exposure
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Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma
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ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.