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54 results for “deleterious mutations”
Data from: Deleterious mutations show increasing negative effects with age in Drosophila melanogaster
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Data from: The effect of deleterious mutations and age on recombination in Drosophila melanogaster
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Data from: Sexual selection is ineffectual or inhibits the purging of deleterious mutations in Drosophila melanogaster
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Data from: Abiotic stress does not magnify the deleterious effects of spontaneous mutations
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The mRNA expression in the sarcomas of Li-Fraumeni syndrome mouse harboring a deleterious p53 mutation
GEO Series GSE234883. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Vulnerability and life-history traits correlate with the load of deleterious mutations in fish
<p><strong>Phylogenetic dataset associated to the article : Vulnerability and life-history traits correlate with the load of deleterious mutations in fish</strong></p> <ul> <li>fastagenes.tar.gz : all the fasta file alignments used for the study.</li> <li>teleost.tr: phylogenetic tree used for mapnh et codeml analyses.</li> <li>tree-date.tr : phylogenetic tree used to control for phylogeny (tip labels corresponding to alignments).</li> <li>tree-date_spNames.tre : phylogenetic tree used to control for phylogeny (tip labels = species names).</li> <li> <p>ENSDARE00000004235_nucl.fasta.bppml_dnds: example of option file for bppml.</p> </li> <li> <p>ENSDARE00000004235_nucl.fasta.mapnhYN98: example of option file for mapnh.</p> </li> <li> <p>ENSDARE00000004235_nucl.phylip.ctl: example of control file for codeml.</p> <p> </p> <p> </p> <p> </p> </li> </ul>
Data from: Impact of deleterious mutations, sexually antagonistic selection and mode of recombination suppression on transitions between male and female heterogamety.
Deleterious mutations accumulating on non-recombining Y chromosomes can drive XY to XY turnovers, as they allow to replace the old mutation-loaded Y by a new mutation-free one. The same process is thought to prevent XY to ZW turnovers, because the latter requires fixation of the ancestral Y, assuming dominance of the emergent feminizing mutation. Using individual-based simulations, we explored whether and how an epistatically dominant W allele can spread in a young XY system that gradually accumulates deleterious mutations. We also investigated how sexually antagonistic (SA) polymorphism on the ancestral sex chromosomes and the mechanism controlling X-Y recombination suppression affect these transitions. In contrast with XY to XY turnovers, XY to ZW turnovers cannot be favored by Y chromosome mutation load. If the arrest of X-Y recombination depends on genotypic sex, transitions are strongly hindered by deleterious mutations, and totally suppressed by very small SA cost, because deleterious mutations and female-detrimental SA alleles would have to fix with the Y. If, however, the arrest of X-Y recombination depends on phenotypic sex, X and Y recombine in XY ZW females, allowing for the purge of Y-linked deleterious mutations and loss of the SA polymorphism, causing XY to ZW turnovers to occur at the same rate as in the absence of deleterious and sex-antagonistic mutations. We generalize our results to other types of turnovers (e.g., triggered by non-dominant sex-determining mutations) and discuss their empirical relevance.
A Bioequivalence Study to Evaluate Pharmacokinetics and Safety of BR2022 and BR2022-1 in Patients With Deleterious or Suspected Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer
ClinicalTrials.gov study NCT07069335. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Rucaparib in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation
ClinicalTrials.gov study NCT02042378. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Study Evaluating DNA Double-strand Breaks (DSBs) REpair Factors (POLQ, Shieldin Complex and 53BP1) Expression as Biomarker of PARP Inhibitor Resistance in Patients With Deleterious Germline Mutation i
ClinicalTrials.gov study NCT05378204. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comprehensive Analysis of Predictors of the Treatment With Pembrolizumab and Olaparib in Patients With Unresectable or Metastatic HER2 Negative Breast Cancer and a Deleterious Germline Mutation or a H
ClinicalTrials.gov study NCT05033756. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: No signal of deleterious mutation accumulation in conserved gene sequences of extant asexual hexapods
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Data from: Impact of deleterious mutations, sexually antagonistic selection and mode of recombination suppression on transitions between male and female heterogamety.
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Data from: Spatial heterogeneity in the strength of selection against deleterious alleles and the mutation load
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.