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34,778 results for “diseases”
PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWLNETS (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-Standard Relations-OWLNETS</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWLNETS (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-Inverse Relations-OWLNETS</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWL (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-StandardRelations-OWL</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWLNETS (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-StandardRelations-OWLNETS</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWL (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-InverseRelations-OWL</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWL (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-Inverse Relations-OWL</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWLNETS (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-InverseRelations-OWLNETS</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Standard Relations-OWLNETS (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-Standard Relations-OWLNETS</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWLNETS (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-Inverse Relations-OWLNETS</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWL (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-Inverse Relations-OWL</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWL (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-InverseRelations-OWL</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Standard Relations-OWLNETS (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-Standard Relations-OWLNETS</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
Data from: Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation.
<p>ABSTRACT </p><p>Krabbe disease (KD) is a rare disorder caused by a deficiency of the lysosomal enzyme galactosylceramidase (GALC), resulting in the accumulation of the cytotoxic metabolite psychosine (PSY) in the nervous system. This accumulation triggers demyelination and neurodegeneration. Despite ongoing research, the underlying pathogenic mechanisms remain incompletely understood, and there is currently no cure available.</p><p>Previous studies from our lab revealed the presence of autophagy dysfunctions in KD pathogenesis, as evidenced by the presence of p62-tagged protein aggregates in the brains of KD mice and increased p62 levels in the KD sciatic nerve. We also demonstrated that the autophagy inducer Rapamycin (RAPA) can partially restore the wild-type (WT) phenotype in KD primary cells by reducing the number of p62 aggregates.</p><p>In this study, we tested RAPA in the Twitcher (TWI) mouse, a spontaneous KD mouse model. We administered the drug ad libitum via drinking water (15 mg/L) starting from post-natal day (PND) 21-23. We longitudinally monitored the motor performance of the mice through grip strength and rotarod tests, along with various biochemical parameters related to KD pathogenesis (i.e. autophagy markers expression, myelination, astrogliosis, and PSY accumulation).</p><p>Our findings demonstrate that RAPA significantly enhances motor functions at specific treatment time points and reduces astrogliosis in TWI brain, spinal cord, and sciatic nerves. Using western blot and immunohistochemistry, we observed a decrease in p62 aggregates in TWI nervous tissues, which corroborates our earlier in-vitro results. Furthermore, RAPA treatment partially reduces PSY levels in the spinal cord.</p><p>In conclusion, our results support the consideration of RAPA as a supportive therapy for KD. Importantly, as RAPA is already available in pharmaceutical formulations for clinical use, its potential for KD treatment can be promptly evaluated in clinical trials.</p>
ARCADE: Automatic Region-based Coronary Artery Disease diagnostics using x-ray angiography imagEs Dataset
<p>ARCADE: Automatic Region-based Coronary Artery Disease diagnostics using x-ray angiography imagEs Dataset Phase 2 consist of two folders with 300 images in each of them as well as annotations. </p> <p>ARCADE: Automatic Region-based Coronary Artery Disease diagnostics using x-ray angiography imagEs Dataset Phase 1 consists of two datasets of XCA images for each of two tasks of ARCADE challenge. The first task includes in total 1200 coronary vessel tree images, which are divided into train(1000) and validation(200) groups, images for training are followed with annotations, depicting the division of a heart into 26 different regions based on the Syntax Score methodology[1]. Similarly, the second task includes a different set of 1200 images with same train-val division proportion with annotated regions containing atherosclerotic plaques. This dataset, carefully annotated by medical experts, enables scientists to actively contribute towards the advancement of an automated risk assessment system for patients with CAD. </p> <p>The dataset structure is as follows: top-level directories "syntax" and "stenosis" contain files for the two dataset objectives, namely: i) vessel branch classification according to the SYNTAX methodology; and ii) stenosis detection. Inside both directories, there are 3 subsets of the dataset, such as "train", "val", and "test". Inside each of those folders, there are 2 lower-level directories - "images", and "annotations". Inside the "images" folder there are images in ".png" format, extracted from DICOM recordings. The "annotations" folders contain single ".JSON" files, which are named in correspondence to the objective, i.e. "train.JSON", "val.JSON", and "test.JSON".</p> <p>The structure of ".JSON" contains three top-level fields: "images", "categories", and "annotations". The "images" field contains the unique "id" of the image in the dataset, its "width" and "height" in pixels, and the "file_name" sub-field, which contains specific information about the image. The "categories" field contains a unique "id" from 1 to 26, and a "name", relating it to the SYNTAX descriptions. The "annotations" field contains a unique "id" of the annotation, "image_id" value, relating it to the specific image from the "images" field, and a "category_id" relating it to the specific category from the "categories" field. The "segmentation" sub-field contains coordinates of mask edge points in "XYXY" format. Bounding box coordinates are given in the "bbox" field in the "XYWH" format, where the first 2 values represent the x and y coordinates of the left-most and top-most points in the segmentation mask. The height and width of the bounding box are determined by the difference between the right-most and bottom-most points and the first two values. Finally, the "area" field provides the total area of the bounding box, calculated as the area of a rectangle.</p> <p> </p> <p>The corresponding Dataset Article will be provided later. </p> <p>[1] Syntax score segment definitions. https://syntaxscore.org/index.php/tutorial/definitions/14-appendix-i-segment-definitions</p>
Data and code for 'Age truncation due to disease shrinks metapopulation viability for amphibians'
<p>This repository provides all data and R code from the analysis for the following paper:</p> <p>Heard, G.W., Scroggie, M.P., Hollanders, M., and Scheele, B.C. (in press). Age truncation due to disease shrinks metapopulation viability for amphibians. <em>Journal of Applied Ecology</em>. </p> <p>The data are provided as a series of .csv files. A GRD file is provided for the landscape rasters. R code is provided separately for each of the following components:</p> <p>1. A script to complete regression modelling of age structure data for populations of the focal species pre- and post-Bd, plus estimation of adult survival rates from the age structure data using the 'catch curve' approach ('Age_structure_analysis.R').</p> <p>2. A script to generate the sample landscapes used for simulations of metapopulation dynamics for the pre- and post-Bd time periods ('Derive_landscape_rasters.R').</p> <p>3. A script with functions for simulating metapopulation dynamics with the aid of the STEPS R package ('STEPS_model.R').</p> <p>4. A script to run the metapopulation simulations across all the demographic and connectivity scenarios, where connectivity scenarios are defined by the sample landscapes ('Run_STEPS_simulations.R'). </p> <p>5. A script to fit logistic regression models to the outcomes of the metapopulation simulations (extinction versus persistence) ('Metapop_sims_analysis_GLM.R').</p> <p>6. A script to fit multivariate normal hypervolumes to the outcomes of the metapopulation simulations (extinction versus persistence) ('Metapop_sims_analysis_MVNH.R').</p> <p>7. A script to generate each of the figures in the manuscript, plus Table 2 which requires post-hoc data compilation ('Generate_figures.R'). </p> <p>In combination, the data files and scripts allow all analyses from the paper to be reproduced. </p>
Pathogen lifestyle determines host genetic signature of quantitative disease resistance loci in oilseed rape (Brassica napus)
<p>Supplemental datasets associated with publication: Pathogen lifestyle determines host genetic signature of quantitative disease resistance loci in oilseed rape (<em>Brassica napus</em>)</p> <p><strong>Abstract</strong></p> <ul> <li>Crops are affected by several pathogens, but these are rarely studied in parallel to identify common and unique genetic factors controlling diseases. Broad-spectrum quantitative disease resistance (QDR) is desirable for crop breeding as it confers resistance to several pathogen species.</li> <li>Here, we use associative transcriptomics (AT) to identify candidate gene loci associated with <em>Brassica napus</em> constitutive QDR to four contrasting fungal pathogens: <em>Alternaria brassicicola</em>, <em>Botrytis cinerea</em>, <em>Pyrenopeziza</em><em> brassicae</em> and <em>Verticillium longisporum. </em>We did not identify any loci associated with broad-spectrum QDR to fungal pathogens with contrasting lifestyles. Instead, we observed QDR dependent on the lifestyle of the pathogen—hemibiotrophic and necrotrophic pathogens had distinct QDR responses and associated loci, including some loci associated with early immunity. Furthermore, we identify a genomic deletion associated with resistance to <em>V. longisporum </em>and potentially broad-spectrum QDR.</li> <li>This is the first time AT has been used for several pathosystems simultaneously to identify host genetic loci involved in broad-spectrum QDR. We highlight constitutively expressed candidate loci for broad-spectrum QDR with no antagonistic effects on susceptibility to the other pathogens studies as candidates for crop breeding. In conclusion, this study represents and advancement in our understanding if broad-spectrum QDR in <em>B. napus </em>and is a significant resource for the scientific community. </li> </ul> <p><strong>Description of data files</strong></p> <p><strong>Full dataset for input into AT analysis </strong>Full datasets (infection phenotypes for <em>A. brassicicola, B. cinerea, </em>or <em>V.longisporum, </em>ROS measurements for chitin, flg22, or elf18) and link to original <em>P. brassicae </em>dataset. These datasets were used for input into the Associative Transcriptomics pipeline (Nichols, 2022, <a href="https://github.com/bsnichols/GAGA. https://zenodo.org/badge/latestdoi/512807075">https://github.com/bsnichols/GAGA. https://zenodo.org/badge/latestdoi/512807075</a>). </p> <p><strong>Table S1 </strong>Mean, normalized phenotype data for resistance to pathogens (<em>Alternaria brassicicola, Botrytis cinerea, Pyrenopeziza brassicae </em>and <em>Verticillium longisporum</em>) and ROS response induced by PAMPS (chitin, flg22, and elf18). These data were used for association transcriptomic analysis.<strong> </strong></p> <p><strong>Table S2 </strong>Full list of single nucleotide polymorphism (SNP) markers and significance levels from genome-wide association (GWA) analyses for resistance to pathogens (<em>Alternaria brassicicola, Botrytis cinerea, Pyrenopeziza brassicae </em>and <em>Verticillium longisporum</em>) and ROS response induced by PAMPS (chitin, flg22, and elf18). Each excel tab contains the analyses for a single trait. The best fit model for GWA analysis is indicated in the tab title. Manhattan plots showing marker-trait association are included for data visualization; x-axis indicates SNP location along the chromosome; the y-axis indicates the -log10(p) (P value). Qqplots are included to demonstrate model fit.</p> <p><strong>Table S3</strong> Full list of gene expression markers (GEMs) and significance levels from GEM analyses for resistance to pathogens (<em>Alternaria brassicicola, Botrytis cinerea, Pyrenopeziza brassicae and Verticillium longisporum</em>) and ROS response induced by PAMPS (chitin, flg22, and elf18). Each excel tab contains the analyses for a single trait. Manhattan plots showing marker-trait association are included for data visualization; x-axis indicates GEM location along the chromosome; the y-axis indicates the -log10(p) (P value). </p> <p><strong>Table S4 </strong>184 gene expression markers (GEMs) associated with chitin-induced ROS compared with GEMs associated with resistance to pathogens (<em>Alternaria brassicicola, Botrytis cinerea, Pyrenopeziza brassicae </em>and<em> Verticillium longisporum</em>) and ROS response induced by flg22, and elf18. Lists correspond to Venn diagrams in Fig. 2. The first tab includes all 184 GEMs associated with chitin-induced ROS. The subsequent tabs include lists of shared GEMs associated with chitin-induced ROS response and each additional trait (quantitative disease resistance (QDR) to each fungal pathogen or additional PAMP-induced ROS responses). The title of each tab indicates the data included in each comparison and the number of shared GEMs. Predicted <em>Arabidopsis thaliana</em> orthologs and corresponding descriptions are shown where possible. </p> <p><strong>Table S5</strong> Enrichment analyses to determine if the number of gene expression markers (GEMs) shared between different lists is greater than the number of GEMs that would be expected by chance (e.g., lists of quantitative disease resistance (QDR) GEMs for two fungal pathogens). The representation factor is the number of overlapping GEMs divided by the expected number of overlapping GEMs drawn from two independent groups (traits), considering the total number of GEMs sequenced (53884). A representation factor > 1 indicates more overlap than expected of two groups, a representation factor < 1 indicates less overlap than expected, and a representation factor of 1 indicates that the two groups by the number of genes expected for independent groups of genes. </p> <p><strong>Table S6 R</strong>esults from Weighted Co-expression Gene Network Analysis (WGCNA). The first tab indicates significant modules from WGCNA analysis. Black and magenta modules are associated with antagonistic effects on resistance/susceptibility to all four pathogens. The second tab includes a full list of the GEM markers (Table S3), which are in significant WGCNA modules. The third, fourth and, fifth tabs indicate all significant GEMs in the black module, GO terms associated with GEMs in the black module, and all GO terms associated with the black module, respectively. The sixth, seventh and, eighth tabs indicate all significant GEMs in the magenta module, GO terms associated with GEMs in the magenta module, and all GO terms associated with the magenta module, respectively.</p> <p><strong>Table S7 </strong>Shared gene expression markers (GEMs) associated with resistance to different pathogens (<em>Alternaria brassicicola, Botrytis cinerea, Pyrenopeziza brassicae </em>and <em>Verticillium longisporum</em>). Lists correspond to matrices and Venn diagrams in Fig. 3. The first tab includes all GEMs associated quantitative disease resistance (QDR) to the fungal pathogens. The subsequent tabs include lists of shared GEMs associated with QDR to two or more fungal pathogens. The title of each tab indicates the data included in each comparison and the number of shared GEMs. Predicted <em>Arabidopsis thaliana</em> orthologs and corresponding descriptions are shown where possible. </p> <p><strong>Table S8 </strong>List of genes in linkage disequilibrium with the top marker for <em>Verticillium longisporum</em> resistance from genome-wide association (GWA) analysis on chromosome A09 (107 genes)(Tab 1) and the homoeologous region on C08 (Tab 2). Their percentage identity and query coverage in <em>Brassica napus</em> reference genotypes Quinta, Tapidor, Westar and Zhongshuang 11 compared to the <em>B. napus</em> pantranscriptome is indicated. Predicted <em>Arabidopsis thaliana</em> orthologs and corresponding descriptions are shown where possible. </p> <p> </p>
A scoping review on bovine tuberculosis highlights the need for novel data streams and analytical approaches to curb zoonotic diseases
<p>The following data and scripts are part of the manuscript titled 'A scoping review on bovine tuberculosis highlights the need for novel data streams and analytical approaches to curb zoonotic diseases' which is currently going through the peer-review process and has already been published as a preprint. Please read the README.txt file for information on the files uploaded.</p>
Data and analysis for: "Persistent Spatial Clustering and Predictors of Pediatric La Crosse Virus Neuroinvasive Disease Risk in Eastern Tennessee and Western North Carolina, 2003–2020"
<p>This is the initial release of the data and code corresponding to the manuscript submitted to PLoS Neglected Tropical Diseases. <strong>Please refer to the README.md file</strong> for a description of the contents of this repository and how to use them. The README file can be opened with a text editor, or viewed directly in the GitHub repository. The data and code are provided within a project directory with a reproducible R package library for ease and accuracy of reproducibility. </p> <p><strong>Ethics Approval</strong></p> <p>This study was approved by the University of Tennessee, Knoxville Institutional Review Board (UTK IRB-22-07079-XP) and the Tennessee Department of Health Institutional Review Board (TDH IRB 2021-0314). Data provided here is de-identified and aggregated (both temporally and spatially) to protect the privacy of individuals included in the study, in concordance with IRB and Data Use Agreements.</p>
Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson's Disease: A double-blind, randomized, crossover study.
<p><strong><span>Abstract: <span>Background/Objectives:</span></span></strong><span> Preclinical studies have evidenced a peripheral nerve blockade with kilohertz high-frequency alternating current (KHFAC) stimulation. It could have a potential effect on aberrant nerve hyperactivity, such as tremor in people with Parkinson’s disease (PwPD). The objective was to investigate the effects of transcutaneous KHFAC at 10 kHz compared with sham intervention on tremor modulation, upper limb motor function, and adverse events in PwPD. <strong>Methods:</strong> This randomized, double-blind, crossover trial included PwPD, who received transcutaneous KHFAC and sham interventions, within a 48h washout period. Measurements were taken pre-intervention, during, immediately after, and 10 minutes post-intervention. The main outcomes were rest, postural, and kinetic tremor acceleration. Secondary outcomes were handgrip strength, nine-hole peg test (NHPT), movement onset time, and adverse events.<strong> </strong></span></p>
Splicing accuracy varies across human introns, tissues, age and disease
<p>Alternative splicing impacts most multi-exonic human genes. Inaccuracies during this process may have an important role in ageing and disease. Here, we investigated splicing accuracy using RNA-sequencing data from >14K control samples and 40 human body sites, focusing on split reads partially mapping to known transcripts in annotation. We show that splicing inaccuracies occur at different rates across introns and tissues and are primarily affected by the abundance of core components of the spliceosome assembly and its regulators. Using publicly available data from RNA-knockdowns and CLIP-seq binding sites of numerous spliceosomal components and related regulators, we demonstrated the importance of RNA-binding proteins in splicing accuracy. We found that age is positively correlated with a global decline in splicing fidelity, mostly affecting genes implicated in neurodegenerative diseases. We found further support for the latter by observing a genome-wide increase in splicing inaccuracies in samples affected with Alzheimer's disease as compared to neurologically normal individuals. This in-depth characterisation of splicing has important implications for our understanding of the role of inaccuracies in ageing and human disease, particularly in neurodegenerative disorders.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.