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Dataset results
135 results for “drug delivery”
Triamcinolone Acetonide Injections in Mild-to-moderate Chronic Plaque Psoriasis With a Novel Needle-free Drug-delivery System
ClinicalTrials.gov study NCT04410237. IPD Sharing: NO. Countries: 1. Publications: 16.
The Feasibility of Drug Delivery to Infants During Breastfeeding
ClinicalTrials.gov study NCT03799367. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Drug Delivery Devices for Osteomyelitis
ClinicalTrials.gov study NCT02968693. IPD Sharing: NO. Countries: 1. Publications: 1.
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
ClinicalTrials.gov study NCT04530955. IPD Sharing: NO. Countries: 1. Publications: 7.
Resveratrol loaded chitosan-pectin core-shell nanoparticles as novel drug delivery vehicle for sustained release and improved antioxidant activities
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Figure 1 from: Yordanov Y (2019) Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems. Pharmacia 66(4): 223-231. https://doi.org/10.3897/pharmacia.66.e38571
Figure 1 Number of published papers, containing keywords "caffeic acid phenethyl ester", available at Scopus database.
Data from: Numerical simulations of targeted delivery of magnetic drug aerosols in the human upper and central respiratory system: a validation study
In the present study, we investigate the concept of the targeted delivery of pharmaceutical drug aerosols in an anatomically realistic geometry of the human upper and central respiratory system. The geometry considered extends from the mouth inlet to the 8th generation of the bronchial bifurcations and is identical to the phantom model used in the experimental studies of [Banko {em et al.} (2015), Exp. Fluids, {bf 56} (117):1-12]. In our computer simulations, we combine the transitional Reynolds-Averaged Navier-Stokes (RANS) and the wall-resolved Large Eddy Simulation (LES) methods for the air phase with the Lagrangian approach for the particulate (aerosol) phase. We validated simulations against recently obtained magnetic resonance velocimetry (MRV) measurements of [Banko {em et al.} (2015), Exp. Fluids, {bf 56} (117):1-12] that provide full a 3D mean velocity field for steady inspiratory conditions. Both approaches produced good agreement with experiments, and the transitional RANS approach is selected for the multi-phase simulations of aerosols transport, because of significantly lower computational costs. The local and total deposition efficiency are calculated for different classes of pharmaceutical particles (in the $0.1mu$m$le d_{rm p} le 10mu$m range) without and with a paramagnetic core (the shell-core particles). For the latter, an external magnetic field is imposed. The source of the imposed magnetic field was placed in the proximity of the first bronchial bifurcation. We demonstrated that both total- and local-depositions of aerosols at targeted locations can be significantly increased by an applied magnetization force. This finding confirms the possible potential for further advancement of the magnetic drug targeting (MDT) technique for more efficient treatments for respiratory diseases.
Data from: Anthracycline drugs on modified surface of quercetin-loaded polymer nanoparticles: a dual drug delivery model for cancer treatment
Polymer nanoparticles are vehicles used for delivery of hydrophobic anti-cancer drugs, like doxorubicin, paclitaxel or chemopreventors like quercetin (Q). The present study deals with the synthesis and characterisation of nano formulations (NFs) from Q loaded PLGA (poly lactic-co-glycolic acid) nano particles (NPs) by surface modification. The surface of Q-loaded (NPs) is modified by coating with biopolymers like bovine serum albumin (BSA) or histones (His). Conventional chemotherapeutic drugs adriamycin (ADR) and mitoxantrone (MTX) are bound to BSA and His respectively before being coated on Q-loaded NPs to nano formulate NF1 and NF2 respectively. The sizes of these NFs are in the range 400-500 nm as ascertained by SEM and DLS measurements. Encapsulation of Q in polymer NPs is confirmed from shifts in FT-IR, TGA and DSC traces of Q-loaded NPs compared to native PLGA and Q. Surface modification in NFs is evidenced by three distinct regions in their TEM images; the core, polymer capsule and the coated surface. Negative zeta potential of Q-loaded NPs shifted to positive potential on surface modification in NF1 and NF2. In vitro release of Q from the NFs lasted up to twenty days with an early burst release. NF2 is better formulation than NF1 as loading of MTX is 85% compared to 23% loading of ADR. Such NFs are expected to overcome multi-drug resistance (MDR) by reaching and treating the target cancerous cells by virtue of size, charge and retention.
Figure 2 from: Hamdan I (2024) Microneedle and drug delivery across the skin: An overview. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112503
Figure 2 Schematic representation of MN types and delivery approaches. A. Solid non-coated; B. Solid coated; C. Dissolving; D. Hollow and E. Swellable MNs.
Figure 1 from: Hamdan I (2024) Microneedle and drug delivery across the skin: An overview. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112503
Figure 1 The structure of the skin. The epidermis, dermis, and hypodermis. This Figure is generated using ChemDraw professional 16.0.
Figure 4 from: Fitriani EW, Avanti C, Rosana Y, Surini S (2024) Nanostructured lipid carriers: A prospective dermal drug delivery system for natural active ingredients. Pharmacia 71: 1-15. https://doi.org/10.3897/pharmacia.71.e115849
Figure 4 NLC Preparation Methods: High pressure homogenization; High shear homogenization and ultrasonication, Microemulsion, Solvent emulsification/ evaporation, Membrane contractor, Phase inversion temperature, Coacervation.
Nefopam HCl in situ Mucoadhesive liquid suppository, a potential drug delivery system to enhance bioavailability
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Photodynamic Ocular Drug Delivery System with Optical Coherence Tomography Oriented Microscale Robots
<p>Retinal diseases are the most common reason for irreversible blindness worldwide. Common retinal diseases, such as diabetic retinopathy, macular degeneration, retinal vein occlusion, and non-infectious uveitis, mostly require intravitreal steroid injections in clinical management. Unfortunately, intravitreal steroid injections lead to other important ocular problems, such as elevation of intraocular pressure, intravitreal infections, and the progression of cataracts. Because of these reasons, targeted drug delivery systems are necessary for the medical treatment of retinal diseases. PHOTodynamic Ocular Drug delivery system with Optical Coherence Tomography Oriented microscale Robots (PHOTODOCTOR) project combines three novel technologies to solve this important clinical problem. The first technological advancement for the project is dexamethasone-saturated hyaluronic acid (HA) hydrogels with organo-ruthenium complexes, which enables controllable degradation under visible light exposure. With the help of visible light-controlled degradation, dexamethasone will be released with the light pulses. Then the hydrogels will be supplemented with superparamagnetic iron oxide nanoparticles (SPIONs), and 3D printed as helical micro-swimmers. Insertion of the SPIONs will help the magnetic actuation of the hydrogel-based microrobots in the intraocular space. Lastly, SPION-supplemented HA hydrogels will be observed with high-resolution optical coherence tomography (OCT) system in the intraocular space to guide them in diseased areas of the retina. While HA-based structure increases penetration in the vitreous and helps the attachment on the retina, SPIONs will increase the visibility of the microrobots in OCT imaging. In this way, a magnetic-driven, visible light-triggered intraocular drug release system with OCT guidance will be produced, and it could be used not only for intravitreal steroid delivery but also for the treatment of retinal tumours and other retinal problems.</p>
Synthetic molecular motor activates drug delivery from polymersomes
<p>Data sets used for manuscript figures and SI Appendix. These data does not include raw microscopy images or huge raw datasets from the instruments used. Please email the author a.guinart.planellas@rug.nl for access to these files.</p>
NIR-light activated core-shell electrospun Drug Delivery Studies]
<p>Drug Delivery Studies of NIR-light activated core-shell electrospun</p>
Safety and Efficacy of a Glaucoma Drug Delivery System
ClinicalTrials.gov study NCT00824720. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Directed Topical Drug Delivery for Treatment for PASC Hyposmia
ClinicalTrials.gov study NCT05970731. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison Between Drugs for Control of Emetic Attacks During Caesarean Delivery
ClinicalTrials.gov study NCT06300346. IPD Sharing: UNDECIDED. Countries: 0. Publications: 4.
Safety Extension Study to Evaluate the Biodegradation of the Brimonidine Tartrate Posterior Segment Drug Delivery System
ClinicalTrials.gov study NCT01080209. IPD Sharing: Not stated. Countries: 12. Publications: 0.
Garcinia Mangostana L.Pericarp Gel as a Local Drug Delivery in Treatment of Chronic Periodontitis
ClinicalTrials.gov study NCT02880397. IPD Sharing: NO. Countries: 0. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.