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47 results for “evolutionary determinism”
Data from: Novel evolutionary pathways of sex-determining mechanisms
Evolutionary transitions between sex-determining mechanisms (SDMs) are an enigma. Among vertebrates, individual sex (male or female) is primarily determined by either genes (genotypic sex determination, GSD) or embryonic incubation temperature (temperature-dependent sex determination, TSD), and these mechanisms have undergone repeated evolutionary transitions. Despite this evolutionary lability, transitions from GSD (i.e. from male heterogamety, XX/XY, or female heterogamety, ZZ/ZW) to TSD are an evolutionary conundrum, as they appear to require crossing a fitness valley arising from the production of genotypes with reduced viability owing to being homogametic for degenerated sex chromosomes (YY or WW individuals). Moreover, it is unclear whether alternative (e.g. mixed) forms of sex-determination can persist across evolutionary time. It has previously been suggested that transitions would be easy if temperature-dependent sex-reversal (e.g. XX male or XY female) were asymmetrical, occurring only in the homogametic sex. However, only recently has a mechanistic model of sex determination emerged that may allow such asymmetrical sex-reversal. We demonstrate that selection for TSD in a realistic sex-determining system can readily drive evolutionary transitions from GSD to TSD that do not require the production of YY or WW individuals. In XX /XY systems, sex-reversal (female to male) occurs in a portion of the XX individuals only, leading to the loss of the Y allele (or chromosome) from the population as XX individuals mate with each other. The outcome is a population of XX individuals whose sex is determined by incubation temperature (TSD). Moreover, our model reveals a novel evolutionarily stable state representing a mixed-mechanism system that has not been revealed by previous approaches. This study solves two long-standing puzzles of the evolution of sex-determining mechanisms by illuminating the evolutionary pathways and endpoints.
Data from: Adaptation to environmental temperature is a major determinant of molecular evolutionary rates in Archaea
Open the record for dataset details and reuse information.
Data from: Novel evolutionary pathways of sex-determining mechanisms
Open the record for dataset details and reuse information.
The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila.
GEO Series GSE253028. Drosophila melanogaster. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [ChIP-seq]
GEO Series GSE253026. Drosophila melanogaster. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [ATAC-seq]
GEO Series GSE253025. Drosophila melanogaster. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [CUT&RUN]
GEO Series GSE253027. Drosophila melanogaster. 3 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.