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66 results for “fitness landscapes”
Data from: Inferring fitness landscapes and selection on phenotypic states from single-cell genealogical data
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Data from: Fisher's geometrical model of fitness landscape and variance in fitness within a changing environment
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Data from: Evolutionary advantage of small populations on complex fitness landscapes
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Data from: Mapping the fitness landscape of gene expression uncovers the cause of antagonism and sign epistasis between adaptive mutations
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Data from: Male competition fitness landscapes predict both forward and reverse speciation
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Data from: Variation in the post-mating fitness landscape in fruitflies
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Data from: Sex and genotype effects on nutrient-dependent fitness landscapes in Drosophila melanogaster
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Data from: The fitness landscape of the codon space across environments
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Data from: Shifting fitness landscapes in response to altered environments
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Data from: Mapping a systematic ribozyme fitness landscape reveals a frustrated evolutionary network for self-aminoacylating RNA
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Data from: Host use dynamics in a heterogeneous fitness landscape generates oscillations in host range and diversification
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Data from: On the (un)predictability of a large intragenic fitness landscape
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Experimental assay of a fitness landscape on a macroevolutionary scale
GEO Series GSE99990. Saccharomyces cerevisiae. 24 samples. Type: Genome variation profiling by high throughput sequencing.
Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design
GEO Series GSE139657. Adeno-associated virus. 169 samples. Type: Other.
Combinatorial in vivo genome editing identifies widespread epistasis and an accessible fitness landscape during lung tumorigenesis
GEO Series GSE281604. Mus musculus. 74 samples. Type: Other.
A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo
GEO Series GSE98207. Mus musculus. 36 samples. Type: Other.
Data from: Long-term evolution on complex fitness landscapes when mutation is weak
Understanding evolution on complex fitness landscapes is difficult both because of the large dimensionality of sequence space and the stochasticity inherent to population-genetic processes. Here I present an integrated suite of mathematical tools for understanding evolution on time-invariant fitness landscapes when mutations occur sufficiently rarely that the population is typically monomorphic and evolution can be modeled as a sequence of well-separated fixation events. The basic intuition behind this suite of tools is that surrounding any particular genotype lies a region of the fitness landscape that is easy to evolve to, while other pieces of the fitness landscape are difficult to evolve to (due to distance, being across a fitness valley, etc.). I propose a rigorous definition for this ``dynamical neighborhood' of a genotype which captures several aspects of the distribution of waiting times to evolve from one genotype to another. The neighborhood structure of the landscape as a whole can be summarized as a matrix, and I show how this matrix can be used to approximate the expected waiting time for certain evolutionary events to occur and to provide an intuitive interpretation to existing formal results on the index of dispersion of the molecular clock.
Data from: Long-term evolution on complex fitness landscapes when mutation is weak
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Spurious regulatory connections dictate the expression-fitness landscape of translation factors
GEO Series GSE162169. Bacillus subtilis. 107 samples. Type: Expression profiling by high throughput sequencing; Other.
Fitness Landscape of Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms
GEO Series GSE26142. Pseudomonas aeruginosa. 5 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.