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238
datasets available to search
ShareScore release 0.9.0
Dataset results
238 results for “functional phenotype”
Phenotypic and Functional Characterisation of Human B-cell Response in Pemphigus
ClinicalTrials.gov study NCT04117529. IPD Sharing: NO. Countries: 1. Publications: 5.
Study of Phenotypic and Functional Characteristics of Regulatory T Lymphocytes in Horton's Disease
ClinicalTrials.gov study NCT02857192. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Functional Brain Imaging of Pain Phenotype and Genotype
ClinicalTrials.gov study NCT01777087. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to Phenotype
ClinicalTrials.gov study NCT04901715. IPD Sharing: YES. Countries: 1. Publications: 0.
Image-Based Structural and Functional Phenotyping of the COSYCONET Cohort Using MRI and CT
ClinicalTrials.gov study NCT02629432. IPD Sharing: YES. Countries: 1. Publications: 6.
Data from: Performance in three shell functions predicts the phenotypic distribution of hard-shelled turtles
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Intraspecific variation of Phragmites australis: Clinal adaption of functional traits and phenotypic plasticity vary with latitude of origin
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Data from: Phenotypic integration in the carnivoran backbone and the evolution of functional differentiation in metameric structures
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Data from: Ontogenetic changes in the phenotypic integration and modularity of leaf functional traits
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Life history predicts flight muscle phenotype and function in birds
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Data from: The search for Pleiades in trait constellations: functional integration and phenotypic selection in the complex flowers of Morrenia brachystephana (Apocynaceae)
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Data from: Functional genomic and phenotypic responses to desiccation in natural populations of a desert drosophilid
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Data from: Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function.
<p>Thymic regulatory T cells (tTreg) are potent inhibitors of autoreactive immune responses and loss of tTreg function results in fatal autoimmune disease. Defects in Treg number or function are also implicated in multiple autoimmune diseases, leading to growing interest in use of Treg as cell therapies to establish immune tolerance. Because tTreg are present at low numbers in circulating blood and may be challenging to purify and expand, and also inherently defective in some subjects, we designed an alternative strategy to creating autologous Treg-like cells from bulk CD4+ T cells. We utilized homology-directed-repair (HDR)-based gene-editing to enforce FOXP3 expression. Targeted insertion of a robust enhancer/promoter proximal to the first coding exon bypassed epigenetic silencing, permitting stable, high level endogenous FOXP3 expression. HDR-edited T cells, edTreg, manifested a transcriptional program leading to sustained expression of canonical markers and suppressive activity of tTreg. Both human and murine edTreg mediated immunosuppression in vivo in models of inflammatory disease. Further, this engineering strategy permitted generation of antigen-specific edTreg with robust in vitro and in vivo functional activity. Finally, edTreg could be enriched and expanded at scale using clinically-relevant methods. Together, these finding suggest edTreg production may permit broad future clinical application.</p>
Data from: Many-to-many mapping of phenotype to performance: an extension of the F-matrix for studying functional complexity
Performance capacity influences ecology, behavior and fitness, and is determined by the underlying phenotype. The phenotype-performance relationship can influence the evolutionary trajectory of an organism. Several types of phenotype-performance relationships have been described, including one-to-one relationships between a single phenotypic trait and performance measure, trade-offs and facilitations between a phenotypic trait and multiple performance measures, and redundancies between multiple phenotypic traits and a single performance measure. The F-matrix is an intraspecific matrix of measures of statistical association between phenotype and performance that is used to quantify these relationships. We extend the F-matrix in two ways. First, we use the F-matrix to describe how the different phenotype-performance relationships occur simultaneously and interact in functional systems, a phenomenon we call many-to-many mapping. Second, we develop methods to compare F-matrices among species and compare phenotype-performance relationships at microevolutionary and macroevolutionary levels. We demonstrate the expanded F-matrix approach with a dataset of eight phrynosomatine lizard species, including six phenotypic traits and two measures of locomotor performance. Our results suggest that all types of relationships occur in this system and that phenotypic traits involved in trade-offs are more functionally constrained and tend evolve slower interspecifically than those involved in facilitations or one-to-one relationships.
Data from: Functional traits in red flour beetles: the dispersal phenotype is associated with leg length but not body size nor metabolic rate
Individuals vary in their ability to disperse. Much of this variation can be described by covarying phenotypic traits that are related to dispersal (constituting the 'dispersal phenotype' or 'dispersal syndrome'), but the nature of the associations among these traits is not well understood. Unravelling the associations among traits that potentially constitute the dispersal phenotype provides a foundation for understanding evolutionary trade-offs due to variation in dispersal. Here, we tested five predictions pertaining to the relationships among physiological, morphological and movement traits that are associated with dispersal, using a species with a long history as a laboratory model for studying ecological phenomena, red flour beetles (Tribolium castaneum). We identified a dominant axis of movement ability that describes variation in dispersal-related movement traits. Individuals that scored positively on this axis moved at higher speed, travelled longer distances, had lower movement intermittency and dispersed quicker to a specified area. Relative leg length, but not body size nor routine metabolic rate related positively with movement ability, indicating a likely mechanistic relationship between increased stride length and movement ability. Our data suggest that the dispersal phenotype may be more strongly linked to morphological traits than physiological ones. We demonstrate that associations among many functional traits do not necessarily conform to a priori expectations, and predict that the substantial intraspecific variation in trait values may be important for selection. Movement is a complex behavioural trait, but it has a mechanistic basis in locomotor morphology that warrants further exploration.
Effects of blood cell traits on cardiovascular morpho-functional phenotypes: Evidence from Mendelian randomization analysis
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Investigating the Effect of Short-term Fasting on T Cell Metabolism, Function, and Phenotype in Obesity
ClinicalTrials.gov study NCT05886738. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Effect of Bile Acids on Satiety, Cell Function and Body Weight in Patients With Obesity and Abnormal Satiety Phenotype
ClinicalTrials.gov study NCT05314374. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sleep Disorders, Chronotype, and Functional Impairment in the Restrictive ADHD Phenotype
ClinicalTrials.gov study NCT06970418. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Cardiovascular, Pulmonary, and Integrative Functional Phenotypes in COVID-19 Survivors - Effect of Fenofibrate
ClinicalTrials.gov study NCT05080192. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.