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109
datasets available to search
ShareScore release 0.9.0
Dataset results
109 results for “high-throughput screening”
High-throughput Oligopaint screen identifies druggable 3D genome regulators
GEO Series GSE199607. Homo sapiens. 22 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
High-throughput high-multiplexed screening for splicing factors
GEO Series GSE207344. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Probing the signaling requirements for naïve human pluripotency by high-throughput chemical screening [WGBS]
GEO Series GSE153213. Homo sapiens. 12 samples. Type: Methylation profiling by high throughput sequencing.
High-throughput Transcriptomics Screen of ToxCast Chemicals in HepaRG Cells
GEO Series GSE284321. Homo sapiens. 0 samples. Type: Expression profiling by high throughput sequencing.
A High-Throughput Screen Identifies DYRK inhibitor ID-8 that Stimulates Human Kidney Tubular Proliferation
GEO Series GSE113039. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
High-throughput Transcriptomics Screen of 137 Per- and Polyfluoroalkyl Substances (PFAS) in U-2 OS Cells
GEO Series GSE297135. Homo sapiens. 0 samples. Type: Expression profiling by high throughput sequencing.
High-Throughput Screening of Human Induced Pluripotent Stem Cell Cardiomyocytes Predicts Tyrosine Kinase Inhibitor Cardiotoxicity
GEO Series GSE88944. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
High-throughput screen in post-implantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming
GEO Series GSE164250. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
High-Throughput Transcriptomics Screen of ToxCast Chemicals in U-2 OS Cells
GEO Series GSE274318. Homo sapiens. 0 samples. Type: Other.
High-Throughput Screen Identifies Non-Inflammatory Small Molecule Inducers of Trained Immunity
GEO Series GSE270608. Mus musculus. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Demonstrating the utility of the ex vivo murine mycobacterial growth inhibition assay (MGIA) for high-throughput screening of tuberculosis vaccine candidates against multiple Mycobacterium tuberculosi
GEO Series GSE224467. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
High-throughput Drug Screening Identifies Fluoxetine as a Potential Therapeutic Agent for Neuroendocrine Prostate Cancer
GEO Series GSE224715. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
High-throughput screening of gene expression in the patient's cholangiocarcinoma biopsy
GEO Series GSE107233. Homo sapiens. 1 samples. Type: Expression profiling by array; Third-party reanalysis.
High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells.
GEO Series GSE42529. Homo sapiens. 12 samples. Type: Expression profiling by array.
SOSHI-seq: a high-throughput screening assay to test the functionality of putative response elements for nuclear hormone receptors.
GEO Series GSE298259. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
High-throughput screens of PAM-flexible Cas9 variants for gene knock-out and transcriptional modulation
GEO Series GSE143892. Homo sapiens. 25 samples. Type: Other.
Development and validation of a high-throughput screening pipeline of compound libraries to target EMT
GEO Series GSE284656. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Probing the signaling requirements for naïve human pluripotency by high-throughput chemical screening [RNA-seq]
GEO Series GSE153212. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
High-throughput Drug Screening Identifies Ketotifen as a Potential Therapeutic Agent for Neuroendocrine Prostate Cancer
GEO Series GSE225007. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Data from: High-throughput screening for ligands of the HEPN domain of sacsin
Sacsin is a large protein implicated in the neurodevelopmental and neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), which features the loss of Purkinje neurons in the cerebellum. Although the domain architecture of sacsin suggests that it is a neuronal chaperone assisting in protein quality control, the precise function of sacsin remains elusive. Using fluorescence polarization (FP) assays, we confirmed that the HEPN domain of sacsin binds to nucleotides with low micromolar affinities. FP competition assays with a variety of nucleotides and nucleotide analogs revealed that the binding is primarily mediated by the phosphate groups of nucleotides. A high-throughput screen subsequently identified novel small molecule ligands of HEPN, providing new chemical probes for cell culture studies and drug development. Together, the results are consistent with the HEPN domain contributing to the functional activity of sacsin by binding to nucleotides or other multiply charged anionic compounds in neurons.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.