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ShareScore release 0.9.0
Dataset results
358 results for “human skin”
Explore Effects of Dietary Fish Oil in Human Skin
ClinicalTrials.gov study NCT03122912. IPD Sharing: NO. Countries: 1. Publications: 11.
Human Immunity Against Staphylococcus Aureus Skin Infection
ClinicalTrials.gov study NCT02262819. IPD Sharing: Not stated. Countries: 1. Publications: 2.
High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin
ClinicalTrials.gov study NCT02630303. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Human Skin Aging: Clinical Parameters and Gene Expression Profiling
ClinicalTrials.gov study NCT01451476. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Two-Stage Tuberculin (PPD) Skin Testing in Individuals With Human Immunodeficiency Virus (HIV) Infection
ClinicalTrials.gov study NCT00000955. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Chemical absorption in human skin
Open the record for dataset details and reuse information.
Enhancing the efficiency of mosquito traps: A human skin microbial blend-based approach
Open the record for dataset details and reuse information.
An Exploratory Study Investigating Human Skin Reaction to Output
ClinicalTrials.gov study NCT02351791. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Assessment of TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light
ClinicalTrials.gov study NCT05398237. IPD Sharing: NO. Countries: 1. Publications: 0.
Retinol on Human Skin Aging in East Asian Descent
ClinicalTrials.gov study NCT02906566. IPD Sharing: NO. Countries: 1. Publications: 0.
Study to Learn More About the Potential of Antifungal Cream V61-044 Containing Trolamine to Cause Irritant Reaction of the Skin to Ultra Violet Light in Healthy Human Subjects
ClinicalTrials.gov study NCT04531527. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Human Participant Study of a Prototype Multilayer Foam Dressing on Intact Skin.
ClinicalTrials.gov study NCT06831448. IPD Sharing: NO. Countries: 1. Publications: 0.
Randomised Controlled Trial of an Antioxidant and Sunscreen Combination Cream for Reducing DNA Damage in Human Skin
ClinicalTrials.gov study NCT07301515. IPD Sharing: YES. Countries: 1. Publications: 0.
Novel Antiaging Regenerative Skin Care Regimen Containing Human Platelet Extract (HPE)
ClinicalTrials.gov study NCT05457491. IPD Sharing: NO. Countries: 1. Publications: 0.
Immune-Related Trafficking and Signaling in Human Skin Associated With Low-Power, Infrared Laser Treatment
ClinicalTrials.gov study NCT02453113. IPD Sharing: NO. Countries: 1. Publications: 0.
Pilot Study of Imaging Human Skin With High-Speed Spectrally Encoded Confocal Microscopy
ClinicalTrials.gov study NCT04566302. IPD Sharing: NO. Countries: 1. Publications: 0.
Human Participant Study of Prototype Non-medicated Multilayer Foam Dressings on Intact Skin
ClinicalTrials.gov study NCT06700850. IPD Sharing: NO. Countries: 1. Publications: 0.
To Investigate Primary Irritation Potential of Four Skin Serum Products on Human Subjects Assessed by 24 Hour Patch Test
ClinicalTrials.gov study NCT03233009. IPD Sharing: NO. Countries: 1. Publications: 0.
Human skin fibroblast mitochondrial depletion 0.5 Gy alpha-particle
Mitochondrial DNA-depleted human skin fibroblasts (HSF rho0) with suppressed oxidative phosphorylation were characterized by significant changes in the expression of 2100 nuclear genes encoding numerous protein classes in NF-kappaB and STAT3 signaling pathways and by decreased activity of the mitochondrial death pathway compared to the parent rho+ HSF. In contrast the extrinsic TRAIL/TRAIL-Receptor-mediated death pathway remained highly active and exogenous TRAIL induced higher levels of apoptosis in rho0 cells compared to rho+ HSF. Global gene expression analysis using microarray and quantitative RT-PCR demonstrated that expression levels of many growth factors and their adaptor proteins (FGF13 HGF IGFBP4 IGFBP6 IGFL2) cytokines (IL6 IL17B IL18 IL19 IL28B) and cytokine receptors (IL1R1 IL21R IL31RA) were substantially decreased after mitochondrial depletion. Some of these genes were targets of NF-kappaB and STAT3 and their protein products could regulate the STAT3 signaling pathway. Alpha-irradiation induced expression of several NF-kappaB/STAT3 target genes including IL1A IL1B IL6 PTGS2/COX2 and MMP12 in rho+ HSF but this response was substantially decreased in rho0 HSF. Suppression of the IKK-NF-kappaB pathway by the small molecular inhibitor BMS-345541 and of the JAK2-STAT3 pathway by AG490 dramatically increased TRAIL-induced apoptosis in the control and irradiated rho+ HSF. Inhibitory antibodies against IL6 the main activator of JAK2-STAT3 pathway added into the cell media also increased TRAIL-induced apoptosis in rho+ HSF. However NF-kappaB activation was partially lost in mitochondrial DNA-depleted HSF resulting in downregulation of the basal or radiation-induced expression of numerous NF-kappaB targets further suppressing IL6-JAK2-STAT3 that in concert with NF-kappaB regulated protection against TRAIL-induced apoptosis. There are 12 total samples 3 biological replicates each of HSF rho+ and rho0 cells that were not irradiated (control=C) or irradiated (alpha=A). Cells were harvested at 4 hours after treatment.
Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model in 16 h after exposure
Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling. Thus identification and characterization of bystander mechanisms will help to development of new treatments of patients with a radiation exposure. In the present study we irradiated 3-dimensional tissue model of human epidermis Epi-200 (Mat-Tek Ashland MA) with 2.5 Gy protons. By exposing only a thin strip across the center of the EPI-200 tissue we have been able to measure global gene expression responses in directly irradiated and bystander cells located at 0.125-0.375 0.375-0.625 0.625-875 mm from the irradiation line. The data were analyzed using BRB-Array Tools (NIH) and further gene ontology analysis and network analysis was performed with Panther (Applied Biosystems) and IPA (Ingenuity) accordingly. Significantly responding genes were identified at all distances and included sets common to both direct and bystander responses. False discovery rate in bystander samples did not exceed 20% (p=0.001) and was sufficiently low in the samples obtained after the whole tissue exposure (0.06-1.16%). Analysis of the fragments cut at the same distance revealed 52 54 and 88 differentially expressed genes. These gene lists overlapped each other had from 3 to 12 genes in common including CLED2 S100A7A. Samples obtained after the whole tissue exposure discovered 949 differentially expressed genes. Moreover the performed gene ontology analysis showed there overrepresentation of TP53 pathway (pathways p=2.04E-02) a common marker of direct irradiation response and also overrepresentation of the following groups of genes: signal transduction (p=4.52E-04) cell communication (p=1.24E-04) and cell cycle in the category of biological processes; DNA helicase activity (p=2.54E-07) receptor binding (p=6.19E-04) calcium ion binding proteins (p=2.57E-03) as the molecular functions. Differentially expresses genes of bystander samples had few categories in common such as cell communication (p=2.36E-03) and signal transduction (p=2.42E-03) among the biological processes and receptor activity (p=4.54E-03) among the molecular functions. Categories specific for the bystander samples included G-protein coupled receptors (p=7.24E-03) and ligand-gated ion channels (p=4.16E-03) suggesting a role of external stimulation and ion trafficking in bystander mechanisms. Radiation induced gene expression in 3-dimensional tissue model Epi-200 was measured in 16 hours after exposure to 2.5 Gy of protons. Four independent experiments were performed for the samples collected at different distances from the irradiation line (125-375 375-625 and 625-875 micrometers) using three tissue fragments per a data point. Moreover three sets of whole tissue irradited samples were also generated for 0 and 2.5 Gy (6 samples total) and used for comparison of bystander and direct responses.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.