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62
datasets available to search
ShareScore release 0.9.0
Dataset results
62 results for “human system modeling”
A human liver cell-based system modeling a clinical prognostic liver signature combined with single-cell RNA-Seq for discovery of liver disease therapeutics
GEO Series GSE173671. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Targeted inhibition of human breast cancer cell line selected as model system of ERBB2-positive/EGFR high breast cancer [RPPA-Shortterm-SKBR3]
GEO Series GSE50106. Homo sapiens. 11 samples. Type: Protein profiling by protein array.
Integration of human stem cell-derived in vitro systems and mouse preclinical models identifies complex pathophysiologic mechanisms in retinal dystrophy
GEO Series GSE220627. Homo sapiens; Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Targeted inhibition of human breast cancer cell lines selected as model systems of ERBB2-positive/EGFR high breast cancer [RPPA-Longterm]
GEO Series GSE36325. Homo sapiens. 2 samples. Type: Protein profiling by protein array.
Targeted inhibition of human breast cancer cell lines selected as model systems of ERBB2-positive/EGFR high breast cancer [RPPA-SKBR3]
GEO Series GSE36326. Homo sapiens. 2 samples. Type: Protein profiling by protein array.
Targeted inhibition of human breast cancer cell lines selected as model systems of ERBB2-positive/EGFR high breast cancer [RPPA-HCC1954]
GEO Series GSE36324. Homo sapiens. 2 samples. Type: Protein profiling by protein array.
Targeted inhibition of human breast cancer cell line selected as model system of ERBB2-positive breast cancer [RPPA-Shortterm-BT474]
GEO Series GSE50104. Homo sapiens. 10 samples. Type: Protein profiling by protein array.
Targeted inhibition of three human breast cancer cell lines as model systems of ERBB2-positive breast cancer
GEO Series GSE50109. Homo sapiens. 74 samples. Type: Protein profiling by protein array.
In vitro Modeling of the Human Dopaminergic System using spatially arranged ventral Midbrain-Striatum-Cortex Assembloids
GEO Series GSE219247. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Targeted inhibition of human breast cancer cell lines selected as model systems of ERBB2-positive/EGFR high breast cancer [RPPA-Longterm-HCC1954-SKBR3]
GEO Series GSE50108. Homo sapiens. 19 samples. Type: Protein profiling by protein array.
Organoids as a model system for researching human neuroendocrine tumor of the breast
GEO Series GSE284118. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Targeted inhibition of human breast cancer cell line selected as model system of ERBB2-positive breast cancer [RPPA-Longterm-BT474]
GEO Series GSE50107. Homo sapiens. 21 samples. Type: Protein profiling by protein array.
Construction and Educational Impact of Plastination Models of the Limbic System, Basal Nuclei, Cerebellum, and Human Spinal Cord
ClinicalTrials.gov study NCT06991933. IPD Sharing: NO. Countries: 0. Publications: 0.
Targeted inhibition of human breast cancer cell lines selected as model systems of ERBB2-positive/EGFR high breast cancer
GEO Series GSE36327. Homo sapiens. 6 samples. Type: Protein profiling by protein array.
A humanized neuronal model system reveals key roles for the trace element manganese in neuronal endocytosis, calcium flux and mitochondrial bioenergetics
GEO Series GSE266943. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Targeted inhibition of human breast cancer cell line selected as model system of ERBB2-positive/EGFR high breast cancer [RPPA-Shortterm-HCC1954]
GEO Series GSE50105. Homo sapiens. 9 samples. Type: Protein profiling by protein array.
Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system
The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular drivers of pathological changes observed in astronauts with the ultimate goals of developing strategies to enable long- term spaceflight and better treatment of diseases on Earth. We used this unique environment to evaluate the effects of microgravity on kidney proximal tubule epithelial cell (PTEC) response to serum exposure and vitaminD biotransformation capacity. To test if microgravity alters the pathologic response of the proximal tubule to serum exposure, we treated PTECs cultured in a microphysiological system (PT-MPS) with human serum and measured biomarkers of toxicity and inflammation (KIM-1 and IL-6) and conducted global transcriptomics via RNAseq on cells undergoing flight (microgravity) and respective controls(ground). Given the profound bone loss observed in microgravity and PTECs produce the active form of vitamin D, we treated 3D cultured PTECs with 25(OH)D 3 (vitamin D) and monitored vitamin D metabolite formation, conducted global transcriptomics via RNAseq, and evaluated transcript expression of CYP27B1, CYP24A1, or CYP3A5 in PTECs undergoing flight (microgravity) and respective ground controls. We demonstrated that microgravity neither altered PTEC metabolism of vitamin D nor did it induce a unique response of PTECs to human serum, suggesting that these fundamental biochemical pathways in the kidney proximal tubule are not significantly altered by short-term exposure to microgravity. Given the prospect of extended spaceflight, more study is needed to determine if these responses are consistent with extended (greater than 6 months) exposure to microgravity.
A Preclinical Model of Human Acute Myeloid Leukemia with an Autologous Immune System for Studying Mechanisms of Tumorigenesis and Immunotherapy
GEO Series GSE79927. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A Human iPSC-derived Organoid System to Model Myelin Destruction and Repair
GEO Series GSE303406. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Fully defined human PSC-derived microglia and tri-culture system reveals cell type specific potentiation of complement C3 production in a model of Alzheimer’s disease
GEO Series GSE139552. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.