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438 results for “hypertrophy”
Ubiquitin Ligase Wwp1 Gene Deletion Attenuates Diastolic Dysfunction in Pressure Overload Hypertrophy
<p><strong><em>Background.</em></strong> Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and accompanied by abnormal extracellular matrix (ECM) accumulation. The E3 ubiquitin ligase WWP1 is a fundamental determinant ECM turnover. We tested the hypothesis that genetic ablation of<em> Wwp1</em> would alter the progression of LVPO induced HFpEF.</p> <p><strong><em>Methods/Results</em></strong><em>.</em> LV echocardiography in mice with global <em>Wwp1</em> deletion (n=41; <em>Wwp1<sup>-/-</sup></em>) was performed at 12 weeks of age (Baseline) and then at 2 and 4 weeks following LVPO (transverse aortic banding) or surgery without LVPO induction. Age-matched wild type mice (<em>Wwp1<sup>+/+</sup></em>; n=33) underwent identical protocols. LV EF remained constant and unchanged with LVPO and LV mass increased in both groups but was lower in the <em>Wwp1<sup>-/-</sup></em> mice. With LVPO, the E/A ratio, an index of LV filling, was 3.97 + 0.46 in <em>Wwp1<sup>+/+</sup></em> but was 1.73 + 0.19 in the <em>Wwp1<sup>-/-</sup></em> group (p<0.05). At the transcriptional level, mRNA for fibrillar collagens (types I and III) decreased by approximately 50% in <em>Wwp1<sup>-/-</sup></em> compared to the <em>Wwp1<sup>+/+</sup></em> group at 4 weeks post-LVPO (p<0.05) and was paralleled by a similar difference in LV fibrillar collagen content as measured by histochemistry. Moreover, mRNA levels for determinants favoring ECM accumulation, such as transforming growth factor (TGF) increased with LVPO, but were lower in the <em>Wwp1<sup>-/-</sup></em> group.</p> <p><strong><em>Summary.</em></strong> The absence of <em>Wwp1</em> reduced the development of LVH and subsequent progression to HFpEF. Modulating the WWP1 pathway could be a therapeutic target to alter the natural history of HFpEF.</p>
A-botulinic Toxin for Symptomatic Benign Prostate Hypertrophy
ClinicalTrials.gov study NCT01275521. IPD Sharing: Not stated. Countries: 1. Publications: 21.
Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy
ClinicalTrials.gov study NCT01328652. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Effect of Etelcalcetide on Cardiac Hypertrophy in Hemodialysis Patients
ClinicalTrials.gov study NCT03182699. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Fabry Disease in High-risk Patients With Left Ventricular Hypertrophy: Prevalence and Implementation of a Clinical Score
ClinicalTrials.gov study NCT04943991. IPD Sharing: NO. Countries: 1. Publications: 3.
Does Dapagliflozin Regress Left Ventricular Hypertrophy In Patients With Type 2 Diabetes?
ClinicalTrials.gov study NCT02956811. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Effect of Extraesophageal Reflux on Inferior Nasal Turbinates Hypertrophy
ClinicalTrials.gov study NCT04581174. IPD Sharing: NO. Countries: 2. Publications: 7.
Adenoid Hypertrophy, Respiratory Complications and Correlation With Infant Feeding Position
ClinicalTrials.gov study NCT04431128. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety and Efficacy of the Irreversible Electroporation (IRE) System for Adenotonsillar Hypertrophy in Children
ClinicalTrials.gov study NCT06960239. IPD Sharing: NO. Countries: 2. Publications: 0.
Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population
ClinicalTrials.gov study NCT03541434. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease
ClinicalTrials.gov study NCT02226510. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Isosorbide Mononitrate on Hypertension to Improve Left Ventricular Hypertrophy, Fibrosis and Myocardial Function
ClinicalTrials.gov study NCT01961453. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Relationship Among, Serum Uric Acid, Left Ventricular Hypertrophy and Metabolic Syndrome
ClinicalTrials.gov study NCT03473951. IPD Sharing: NO. Countries: 1. Publications: 3.
Comparison of Nebulized Budesonide and Intranasal Budesonide Spray in Children With Adenotonsillar Hypertrophy
ClinicalTrials.gov study NCT05325489. IPD Sharing: NO. Countries: 1. Publications: 4.
Efficacy of Aerosal® in the Treatment of Sub-Obstructive Adenotonsillar Hypertrophy and Related Diseases
ClinicalTrials.gov study NCT01574885. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Strategies to Minimize the Risk for Insulin Induced Hypertrophy and Its Related Consequences
ClinicalTrials.gov study NCT07375875. IPD Sharing: NO. Countries: 1. Publications: 0.
Cardiopulmonary Effect of Mechanical Ventilation in Children With Right Ventricular Hypertrophy
ClinicalTrials.gov study NCT04825054. IPD Sharing: NO. Countries: 1. Publications: 1.
Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI in Heart Failure
ClinicalTrials.gov study NCT03084679. IPD Sharing: NO. Countries: 1. Publications: 43.
Antioxidant Vitaminas and Hypertrophy Adaptations to Resistance Training
ClinicalTrials.gov study NCT04828642. IPD Sharing: NO. Countries: 1. Publications: 2.
Use of Autologous Adipose-Derived Stem/Stromal Cells (AD-cSVF) in Symptomatic Benign Prostate Hypertrophy
ClinicalTrials.gov study NCT02961114. IPD Sharing: YES. Countries: 1. Publications: 20.
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International Brain Laboratory public data
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OpenNeuro
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